Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Olusegun Williams"'
Autor:
Brian Aizenstein, Eric J. Kunkel, Kevan M. Shokat, Benjamin T. Houseman, Zachary A. Knight, Olusegun Williams, Randy Hoffman
Publikováno v:
Chemistry & Biology. 17:123-134
PI3Kdelta and PI3Kgamma regulate immune cell signaling, while the related PI3Kalpha and PI3Kbeta regulate cell survival and metabolism. Selective inhibitors of PI3Kdelta/gamma represent a potential class of anti-inflammatory agents lacking the antipr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e736c19c516c10074565d08b3d53cb
https://doi.org/10.1016/j.chembiol.2010.01.010
https://doi.org/10.1016/j.chembiol.2010.01.010
Publikováno v:
Archives of Biochemistry and Biophysics. 484:1-7
A number of inhibitors of kinesin spindle protein (KSP) have been described, which are known from X-ray crystallography studies to bind to an induced fit pocket defined by the L5 loop. We describe the characterization of eight mutant forms of KSP in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d55d207ef4d4c1fec4acf56381eb84
https://doi.org/10.1016/j.abb.2009.01.015
https://doi.org/10.1016/j.abb.2009.01.015
Autor:
Olusegun Williams, David A. Pearce, Kevan M. Shokat, Jian Wang, Zachary A. Knight, Dorothea Fiedler
Publikováno v:
American Journal of Physiology-Renal Physiology. 295:F843-F850
The pathways implicated in the control of epithelial Na+channel (ENaC)-dependent Na+transport in renal collecting duct cells share substantial parallels with those implicated in insulin-regulated glucose metabolism. Notably, both are inhibited by wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e65a8aef7168871520bdad08d3a8f28
https://doi.org/10.1152/ajprenal.90348.2008
https://doi.org/10.1152/ajprenal.90348.2008
Autor:
Benjamin T. Houseman, Kevan M. Shokat, Benjamin S. Braun, Olusegun Williams, Hana L. Goldschmidt, Ernesto Diaz-Flores, Kevin Shannon, Kimberly Krisman, Philippe Depeille, Deepak Sampath, Victor Ng, Gideon Bollag, Jeroen P. Roose, Michael R. Burgess, Jon Akutagawa, Michael Crone
Publikováno v:
Science Signaling. 6
Oncogenic K-Ras proteins, such as K-Ras(G12D), accumulate in the active, guanosine triphosphate (GTP)-bound conformation and stimulate signaling through effector kinases. The presence of the K-Ras(G12D) oncoprotein at a similar abundance to that of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67440c54b390c9806d86e22e28cb1877
https://doi.org/10.1126/scisignal.2004125
https://doi.org/10.1126/scisignal.2004125
Autor:
Matthias Schwarz, Pingda Ren, Simon Miller, Pascale Gaillard, Alex Berndt, Daniel D Le, Jeffrey P. Shaw, Benjamin T. Houseman, Roger L. Williams, Wai-Ching Hon, Thomas Rückle, Kevan M. Shokat, Christian Rommel, Joseph I Pacold, Olusegun Williams, Fabrice Gorrec, Yi Liu
Publikováno v:
Nature chemical biology
Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma. Recently, small-molecule and ATP-competitive PI(3)K inhibitors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5a2e50a5c8ca228e3e74d27c9d3932
https://pubmed.ncbi.nlm.nih.gov/20081818
https://pubmed.ncbi.nlm.nih.gov/20081818
Autor:
Olusegun Williams, Morris E. Feldman, Frann Antignano, Dorothea Fiedler, Gerald Krystal, Kevan M. Shokat, Benjamin T. Houseman, Melisa J. Hamilton, Laura M. Sly, Christina J. van Netten-Thomas, Victor W. Ho, Dana Wong, Etsushi Kuroda, Stephanie L. Omeis, Hayley K. Brugger
Gram-negative bacterial infections, unlike viral infections, do not typically protect against subsequent viral infections. This is puzzling given that lipopolysaccharide (LPS) and double-stranded (ds) RNA both activate the TIR domain–containing ada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a282f5eb40ef776bfae5a28fb38f700
https://europepmc.org/articles/PMC2662641/
https://europepmc.org/articles/PMC2662641/
Autor:
Jeffrey P. Shaw, Thomas Rückle, Benjamin T. Houseman, Yi Liu, Alex Berndt, Pascale Gaillard, Daniel D Le, Joseph I Pacold, Pingda Ren, Matthias Schwarz, Kevan M. Shokat, Christian Rommel, Simon Miller, Roger L. Williams, Wai-Ching Hon, Fabrice Gorrec, Olusegun Williams
Publikováno v:
Nature Chemical Biology. 6:306-306
Corrigendum: The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfde13375b2657db4e41334bd04c33a
https://doi.org/10.1038/nchembio0410-306a
https://doi.org/10.1038/nchembio0410-306a
Autor:
Zachary A. Knight, András Balla, Balazs Toth, David D. Goldenberg, William A. Weiss, Morri E. Feldman, Robbie Loewith, Olusegun Williams, Roger L. Williams, Eli R. Zunder, Kevan M. Shokat, Tamas Balla, David Stokoe, Beatriz González
Publikováno v:
Cell, Vol. 125, No 4 (2006) pp. 733-47
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15281243181685cbf58e16503fc2fa6