IKKβ-NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice.

Autor: Catheline SE; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Bell RD; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Oluoch LS; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA., James MN; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Escalera-Rivera K; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Maynard RD; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Chang ME; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA., Dean C; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA., Botto E; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA., Ketz JP; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA., Boyce BF; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Zuscik MJ; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA.; Colorado Program for Musculoskeletal Research, Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Jonason JH; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA.; Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA.

Publikováno v: Science signaling [Sci Signal] 2021 Sep 21; Vol. 14 (701), pp. eabf3535. Date of Electronic Publication: 2021 Sep 21.