Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Oludotun A, Phillips"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1471-1482 (2020)
Oxazolidinone hydroxamic acid derivatives were synthesised and evaluated for inhibitory activity against leukotriene (LT) biosynthesis in three in vitro cell-based test systems and on direct inhibition of recombinant human 5-lipoxygenase (5-LO). Thir
Externí odkaz:
https://doaj.org/article/dbc11757638142b588f7c508358faa22
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 138, Iss , Pp 111486- (2021)
Erectile dysfunction (ED) is a common diabetic complication. Recent evidence has illuminated the role of hydrogen sulfide (H2S) as a dynamic mediator of the erection process. H2S is a potent endogenous relaxant gas. It has been shown to relax human a
Externí odkaz:
https://doaj.org/article/9808b73886ba4b88ae1993111505e1bc
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 127, Iss , Pp 110210- (2020)
Paclitaxel-induced neuropathic pain (PINP) is a dose-limiting side effect that largely affects the patient’s quality of life and may limit the use of the drug as a chemotherapeutic agent for treating metastatic breast cancer and other solid tumors.
Externí odkaz:
https://doaj.org/article/80ab46c64e8b43c5bed831d79a0e6438
Publikováno v:
Molecules, Vol 27, Iss 3, p 1090 (2022)
The treatment of seizure disorders with currently available pharmacotherapeutic agents is not optimal due to the failure of some patients to respond, coupled with occurrences of side effects. There is therefore a need for research into the developmen
Externí odkaz:
https://doaj.org/article/126e03aa5f674630a43937298c45785d
Autor:
Jaroslav Malina, Viktor Brabec, Patrik Nunhart, Beata Miltáková, Ladislav Janovec, Oludotun A. Phillips, Jana Kasparkova, Edet E. Udo, Maria Kozurkova, Ladislav Novotny, Eva Konkoľová, Mária Matejová
Publikováno v:
Chemical Papers. 74:2327-2337
A series of four new 3,6,9-trisubstituted acridine derivatives (two with fluorine substituents on phenyl ring) were synthesized and their interaction with calf thymus DNA and HSA was investigated using a combination of biochemical, biophysical and bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53881b3943bdf27717f5ecd7ce1f86bd
https://doi.org/10.1007/s11696-020-01079-4
https://doi.org/10.1007/s11696-020-01079-4
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1471-1482 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Oxazolidinone hydroxamic acid derivatives were synthesised and evaluated for inhibitory activity against leukotriene (LT) biosynthesis in three in vitro cell-based test systems and on direct inhibition of recombinant human 5-lipoxygenase (5-LO). Thir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191f924ed121c6ec63449be6ce5b9b97
https://doaj.org/article/dbc11757638142b588f7c508358faa22
https://doaj.org/article/dbc11757638142b588f7c508358faa22
Publikováno v:
Scientia Pharmaceutica, Vol 86, Iss 4, p 42 (2018)
Bacterial resistance towards the existing class of antibacterial drugs continues to increase, posing a significant threat to the clinical usefulness of these drugs. These increasing and alarming rates of antibacterial resistance development and the d
Externí odkaz:
https://doaj.org/article/5db7fd8d8e3f497785a84e91a662165d
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 138, Iss, Pp 111486-(2021)
Erectile dysfunction (ED) is a common diabetic complication. Recent evidence has illuminated the role of hydrogen sulfide (H2S) as a dynamic mediator of the erection process. H2S is a potent endogenous relaxant gas. It has been shown to relax human a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df88cd60bc07678d911b9a88316a0342
http://www.sciencedirect.com/science/article/pii/S0753332221002717
http://www.sciencedirect.com/science/article/pii/S0753332221002717
A novel oxazolidinone derivative PH192 demonstrates anticonvulsant activity in vivo in rats and mice
Publikováno v:
European Journal of Pharmaceutical Sciences. 130:21-26
The pharmacotherapeutic management of seizure disorders with currently available medications is not optimal due to side effects and failure of some patients to respond to all available medications. As such there is the need to develop new antiseizure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c230820b0c7dd27124d77d5439341e
https://doi.org/10.1016/j.ejps.2019.01.011
https://doi.org/10.1016/j.ejps.2019.01.011
Publikováno v:
Scientia Pharmaceutica, Vol 85, Iss 4, p 34 (2017)
Twelve N-substituted-glycinyl triazolyl oxazolidinone derivatives were screened for antimycobacterial activity against susceptible (Mycobacterium tuberculosis (Mtb) H37Rv) and resistant (isoniazid (INH)-resistant Mtb (SRI 1369), rifampin (RMP)-resist
Externí odkaz:
https://doaj.org/article/b1cceb02f324447cbe0ed511ffefbe82