Výsledky vyhledávání - "Olubukayo-Opeyemi Oyetayo"

Pharmacokinetic/pharmaco-dynamic modelling and simulation of the effects of different cannabinoid receptor type 1 antagonists on Δ9-tetrahydrocannabinol challenge tests

Autor: Zheng Guan, Olubukayo-Opeyemi Oyetayo, Jules A. A. C. Heuberger, Joop M. A. van Gerven, Jasper Stevens, Linda E. Klumpers

Publikováno v: British Journal of Clinical Pharmacology. 81:713-723

Aim: The severe psychiatric side effects of cannabinoid receptor type 1 (CB1) antagonists hampered their wide development but this might be overcome by careful management of drug development with pharmacokinetic/pharmacodynamic (PK/PD) analyses. PK/P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b853af23e8035d096cc3692a69bcec2b
https://doi.org/10.1111/bcp.12852

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Towards understanding polyol additive effects on the pH shift-induced aggregation of a monoclonal antibody using high throughput screening and quantitative structure-activity modeling

Autor: Olubukayo-Opeyemi Oyetayo, Hans Kiefer, Oscar Méndez-Lucio, Andreas Bender

Publikováno v: International journal of pharmaceutics. 530(1-2)

pH shift-induced aggregation is frequently observed in downstream processing of monoclonal antibodies and has been shown to depend on solvent composition. To quantify the stabilizing effect of polyol additives against aggregation, we determined aggre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326922a0f48696198ccbafd5a635250b
https://pubmed.ncbi.nlm.nih.gov/28754511

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Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics

Autor: Jules A. A. C. Heuberger, Jan Freijer, Paul D. Morrison, Olubukayo-Opeyemi Oyetayo, Zheng Guan, Tim L. Beumer, Adam F. Cohen, Linda E. Klumpers, Joop M. A. van Gerven

Publikováno v: Clinical Pharmacokinetics, 54(2), 209-219

Δ(9)-Tetrahydrocannobinol (THC), the main psychoactive compound of Cannabis, is known to have a long terminal half-life. However, this characteristic is often ignored in pharmacokinetic (PK) studies of THC, which may affect the accuracy of predictio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf353647bd6db15435dea9952db7f269
https://doi.org/10.1007/s40262-014-0195-5

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Experimental Model System to Study pH Shift-Induced Aggregation of Monoclonal Antibodies Under Controlled Conditions

Autor: Olubukayo-Opeyemi Oyetayo, Hans Kiefer

Publikováno v: Pharmaceutical research. 33(6)

To present a convenient screening method for evaluating additive effects on the renaturation of an acid-exposed monoclonal antibody (mAb). The assay involves brief incubation of a mAb at acidic pH and subsequent neutralization in the absence or prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24f8ec9b281447bee8aa00a59b6ea67
https://pubmed.ncbi.nlm.nih.gov/26928669

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