Minor intron-containing genes as an ancient backbone for viral infection?

Autor: Wuchty S; Department of Computer Science, University of Miami, Coral Gables, FL 33146, USA.; Department of Biology, University of Miami, Coral Gables, FL 33146, USA.; Institute of Data Science and Computing, University of Miami, Coral Gables, FL 33146, USA.; Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33134, USA., White AK; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA., Olthof AM; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA., Drake K; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA., Hume AJ; Department of Virology, Immunology and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA.; Center for Emerging Infectious Diseases Policy and Research, Boston University, Boston, MA 02118, USA., Olejnik J; Department of Virology, Immunology and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA., Aguiar-Pulido V; Department of Computer Science, University of Miami, Coral Gables, FL 33146, USA., Mühlberger E; Department of Virology, Immunology and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02118, USA., Kanadia RN; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT 06269, USA.; Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269, USA.

Publikováno v: PNAS nexus [PNAS Nexus] 2024 Jan 18; Vol. 3 (1), pp. pgad479. Date of Electronic Publication: 2024 Jan 18 (Print Publication: 2024).

Introns: the "dark matter" of the eukaryotic genome.

Autor: Girardini KN; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT, United States., Olthof AM; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT, United States.; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Kanadia RN; Physiology and Neurobiology Department, University of Connecticut, Storrs, CT, United States.; Institute for Systems Genomics, University of Connecticut, Storrs, CT, United States.

Publikováno v: Frontiers in genetics [Front Genet] 2023 May 16; Vol. 14, pp. 1150212. Date of Electronic Publication: 2023 May 16 (Print Publication: 2023).

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns.

Autor: Olthof AM; Physiology and Neurobiology Department, University of Connecticut, 75 N. Eagleville Road, Storrs, CT 06269, USA., White AK; Physiology and Neurobiology Department, University of Connecticut, 75 N. Eagleville Road, Storrs, CT 06269, USA., Mieruszynski S; Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Doggett K; Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Lee MF; Physiology and Neurobiology Department, University of Connecticut, 75 N. Eagleville Road, Storrs, CT 06269, USA., Chakroun A; Neurogenetics, Weill Cornell Medicine-Qatar, Doha, Qatar., Abdel Aleem AK; Neurogenetics, Weill Cornell Medicine-Qatar, Doha, Qatar., Rousseau J; CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada., Magnani C; Neonatology and Neonatal Intensive Care Unit, Maternal and Child Department, University of Parma, Parma, 43121, Italy., Roifman CM; Division of Immunology and Allergy, Department of Pediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, ON M5G 1X8, Canada.; The Canadian Centre for Primary Immunodeficiency and The Jeffrey Modell Research Laboratory for the Diagnosis of Primary Immunodeficiency, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Campeau PM; Department of Pediatrics, University of Montreal, Montreal, QC H4A 3J1, Canada., Heath JK; Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia., Kanadia RN; Physiology and Neurobiology Department, University of Connecticut, 75 N. Eagleville Road, Storrs, CT 06269, USA.; Institute for System Genomics, University of Connecticut, Storrs, CT 06269, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Apr 06; Vol. 49 (6), pp. 3524-3545.

Disrupted minor intron splicing is prevalent in Mendelian disorders.

Autor: Olthof AM; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA., Rasmussen JS; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA., Campeau PM; Department of Pediatrics, University of Montreal, Montreal, QC, Canada., Kanadia RN; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.; Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.

Publikováno v: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Sep; Vol. 8 (9), pp. e1374. Date of Electronic Publication: 2020 Jun 23.

Genes divided according to the relative position of the longest intron show increased representation in different KEGG pathways.

Autor: Dvorak, Pavel^1,2,3 (AUTHOR) Pavel.Dvorak@lfp.cuni.cz, Hlavac, Viktor^2,4 (AUTHOR), Hanicinec, Vojtech² (AUTHOR), Rao, Bhavana Hemantha² (AUTHOR), Soucek, Pavel^2,4 (AUTHOR)

Publikováno v: BMC Genomics. 6/28/2024, Vol. 25 Issue 1, p1-10. 10p.