SARS-CoV-2 viremia but not respiratory viral load is associated with respiratory complications in patients with severe COVID-19.

Autor: Chen L; Department of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA., Olson LB; Duke Medical Scientist Training Program, Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA., Naqvi IA; Department of Surgery, Duke University School of Medicine, Durham, NC, 27710, USA., Sullenger BA; Department of Surgery, Duke University School of Medicine, Durham, NC, 27710, USA., Que LG; Department of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA., Denny TN; Department of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, 27710, USA., Kraft BD; Department of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA. kraft@wustl.edu.

Publikováno v: BMC pulmonary medicine [BMC Pulm Med] 2024 Jul 29; Vol. 24 (1), pp. 366. Date of Electronic Publication: 2024 Jul 29.

Mixed-surface polyamidoamine polymer variants retain nucleic acid-scavenger ability with reduced toxicity.

Autor: Olson LB; Department of Surgery, Duke University, Durham, NC 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Hunter NI; Department of Surgery, Duke University, Durham, NC 27710, USA.; Department of Chemistry, Duke University, Durham, NC 27710, USA., Rempel RE; Department of Surgery, Duke University, Durham, NC 27710, USA., Yu H; Department of Surgery, Duke University, Durham, NC 27710, USA., Spencer DM; Department of Medicine and Immunology, Division of Rheumatology, Duke University Medical Center, Durham, NC 27710, USA., Sullenger CZ; Department of Surgery, Duke University, Durham, NC 27710, USA.; Department of Biology, Duke University, Durham, NC 27710, USA., Greene WS; Collegiate School, New York, NY 10069, USA., Varanko AK; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Eghtesadi SA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Chilkoti A; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Pisetsky DS; Department of Medicine and Immunology, Division of Rheumatology, Duke University Medical Center, Durham, NC 27710, USA.; Medical Research Service, Veterans Administration Medical Center, Durham, NC 27705, USA., Everitt JI; Department of Pathology, Duke University, Durham, NC 27710, USA., Sullenger BA; Department of Surgery, Duke University, Durham, NC 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.

Publikováno v: IScience [iScience] 2022 Nov 09; Vol. 25 (12), pp. 105542. Date of Electronic Publication: 2022 Nov 09 (Print Publication: 2022).

Suppression of Fibrinolysis and Hypercoagulability, Severity of Hypoxemia, and Mortality in COVID-19 Patients: A Retrospective Cohort Study.

Autor: Corey KM; Department of Medicine, Duke University School of Medicine, Durham, North Carolina., Olson LB; Duke Medical Scientist Training Program, Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina., Naqvi IA; Department of Surgery, Duke University School of Medicine, Durham, North Carolina., Morrison SA; Department of Surgery, Duke University School of Medicine, Durham, North Carolina., Davis C; Duke Institute for Health Innovation, Duke University School of Medicine, Durham, North Carolina., Nimjee SM; Department of Neurosurgery, The Ohio State University Medical Center, Columbus, Ohio., Que LG; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina., Bachelder RE; Department of Surgery, Duke University School of Medicine, Durham, North Carolina., Kraft BD; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina., Chen L; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina., Nair SK; Department of Surgery, Duke University School of Medicine, Durham, North Carolina., Levy JH; Departments of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, North Carolina., Sullenger BA; Department of Surgery, Duke University School of Medicine, Durham, North Carolina.

Publikováno v: Anesthesiology [Anesthesiology] 2022 Jul 01; Vol. 137 (1), pp. 67-78.

PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response.

Autor: Ozer I; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Pitoc GA; Department of Surgery, Duke University Medical Center, Durham, NC, 27707, USA., Layzer JM; Department of Surgery, Duke University Medical Center, Durham, NC, 27707, USA.; Duke Clinical and Translational Science Institute, Durham, NC, 27707, USA., Moreno A; Department of Surgery, Duke University Medical Center, Durham, NC, 27707, USA., Olson LB; Department of Surgery, Duke University Medical Center, Durham, NC, 27707, USA., Layzer KD; Department of Surgery, Duke University Medical Center, Durham, NC, 27707, USA., Hucknall AM; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Sullenger BA; Department of Surgery, Duke University Medical Center, Durham, NC, 27707, USA., Chilkoti A; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.

Publikováno v: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2022 Mar; Vol. 34 (10), pp. e2107852. Date of Electronic Publication: 2022 Jan 31.

Rapid test to assess the escape of SARS-CoV-2 variants of concern.

Autor: Heggestad JT; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Britton RJ; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Kinnamon DS; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Wall SA; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Joh DY; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Hucknall AM; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Olson LB; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA., Anderson JG; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., Mazur A; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., Wolfe CR; Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Oguin TH 3rd; Department of Medicine and the Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Sullenger BA; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA., Burke TW; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA., Kraft BD; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Sempowski GD; Department of Medicine and the Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Woods CW; Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University, Durham, NC 27710, USA.; Department of Medicine and the Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Chilkoti A; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.

Publikováno v: Science advances [Sci Adv] 2021 Dec 03; Vol. 7 (49), pp. eabl7682. Date of Electronic Publication: 2021 Dec 03.