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Akademický článek

Copy number and gene expression differences between African American and Caucasian American prostate cancer

Autor: Reuter Victor, Jean-Gilles Jerome, Dash Atreya, Yu Jessie Z, Olshen Adam B, Xu Ruliang, Zhou Qin, Oddoux Carole, Satagopan Jaya M, Rose Amy E, Gerald William L, Lee Peng, Osman Iman

Publikováno v: Journal of Translational Medicine, Vol 8, Iss 1, p 70 (2010)

Abstract Background The goal of our study was to investigate the molecular underpinnings associated with the relatively aggressive clinical behavior of prostate cancer (PCa) in African American (AA) compared to Caucasian American (CA) patients using

Externí odkaz: https://doaj.org/article/51ab7666d9d34c73889d8b840a45a66c

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Akademický článek

A classification model for distinguishing copy number variants from cancer-related alterations

Autor: Olshen Adam B, Nanjangud Gouri, Ostrovnaya Irina

Publikováno v: BMC Bioinformatics, Vol 11, Iss 1, p 297 (2010)

Abstract Background Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in comparative genomic hybridization (CGH) analyses of tumors. In order

Externí odkaz: https://doaj.org/article/d6c93cbc284e4f1a8a9112cb03f3c766

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Akademický článek

Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping

Autor: Ellis Nathan A, Norton Larry, Friedman Eitan, Klein Robert J, Lautenberger James A, Kirchhoff Tomas, Eskin Eleazar, Stefanov Stefan A, Satagopan Jaya, Struewing Jeffery P, Lohmueller Kirk E, Gold Bert, Olshen Adam B, Viale Agnes, Lee Catherine S, Borgen Patrick I, Clark Andrew G, Offit Kenneth, Boyd Jeff

Publikováno v: BMC Genetics, Vol 9, Iss 1, p 14 (2008)

Abstract Background Genetic isolates such as the Ashkenazi Jews (AJ) potentially offer advantages in mapping novel loci in whole genome disease association studies. To analyze patterns of genetic variation in AJ, genotypes of 101 healthy individuals

Externí odkaz: https://doaj.org/article/d75cf59401134973bec3153b8c31b225

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Akademický článek

Breast tumor copy number aberration phenotypes and genomic instability

Autor: Ljung Britt, Tokuyasu Taku, Dairkee Shanaz, Segraves Richard, Olshen Adam, Li Hua, Ylstra Bauke, Snijders Antoine M, Fridlyand Jane, Jain Ajay N, McLennan Jane, Ziegler John, Chin Koei, Devries Sandy, Feiler Heidi, Gray Joe W, Waldman Frederic, Pinkel Daniel, Albertson Donna G

Publikováno v: BMC Cancer, Vol 6, Iss 1, p 96 (2006)

Abstract Background Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g. those inv

Externí odkaz: https://doaj.org/article/f947281d00d148328d754347e4502506

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