Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling

Autor: Wu, Yuteng, Olsen, Lasse B., Lau, Yu Heng, Jensen, Claus Hatt, Rossmann, Maxim, Baker, Ysobel R., Sore, Hannah F., Collins, Súil, Spring, David R.

Publikováno v: Chembiochem

Photoaffinity labelling is a useful method for studying how proteins interact with ligands and biomolecules, and can help identify and characterise new targets for the development of new therapeutics. We present the design and synthesis of a novel mu

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https://www.repository.cam.ac.uk/handle/1810/254078

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Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.

Autor: Wu Y; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Olsen LB; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Lau YH; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Jensen CH; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Rossmann M; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Baker YR; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Sore HF; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Collins S; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK., Spring DR; University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. spring@ch.cam.ac.uk.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2016 Apr 15; Vol. 17 (8), pp. 689-92. Date of Electronic Publication: 2016 Mar 16.