Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Olov A. Wallner"'
Autor:
Thomas Helleday, Bishoy M. F. Hanna, Javier Benitez, Helge Gad, Carlos Benitez-Buelga, Sarah Müller, Raúl Torres-Ruiz, Olov A. Wallner, Sandra Rodriguez-Perales, Maurice Michel, Olga Loseva, Juan Miguel Baquero, Ana Osorio, Varshni Rajagopal, Torkild Visnes, Zhao Zhenjun
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Background: The most common oxidative DNA lesion is 8-oxoguanine (8-oxoG) which is mainly recognized and excised by the glycosylase OGG1, initiating the Base Excision Repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress whic
Autor:
Saeed Eshtad, Ingrid Almlöf, Pål Stenmark, Matthieu Desroses, Armando Cázares-Körner, Evert Homan, Mikael Altun, Azita Rasti, Si Min Zhang, Torsten Schaller, Lars Bräutigam, Hanna Axelsson, Megan Carter, Adam Throup, Rosa Krimpenfort, Tobias Koolmeister, Daniel Rehling, Ann-Sofie Jemth, Thomas Lundbäck, Elisee Wiita, Thomas Helleday, Anna Hagenkort, Brent D. G. Page, Martin Scobie, Ulrika Warpman Berglund, Linda Pudelko, Antonio Sarno, Andreas Krämer, Christina Kalderén, Juliane Kutzner, Olov A. Wallner, Shruti Regmi, Mona Göttmann, Sean G. Rudd, Nicholas C.K. Valerie, Stefan Knapp, Olga Loseva
Publikováno v:
Nature chemical biology
Nature Chemical Biology
Nature Chemical Biology
The NUDIX hydrolase NUDT15 was originally implicated in sanitizing oxidized nucleotides but was later shown to hydrolyze the active thiopurine metabolites, 6-thio-(d)GTP, thereby dictating the clinical response of this standard-of-care treatment for
Autor:
Thomas Helleday, Jonas S. Erjefält, Christina Kalderén, Olov A. Wallner, Christoffer Karlsson, Ravi K. V. Bhongir, Lloyd Tanner, Moritz Heusel, Arne Egesten, Tirthankar Mohanty, Carl-Magnus Clausson, A.B. Single, Cecilia Andersson, Johan Malmström, Riya Oommen
Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. Despite substantial advancement in our understanding of IPF progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffb3ae8ddef71a607bec4eaf9262b30c
https://doi.org/10.21203/rs.3.rs-990197/v1
https://doi.org/10.21203/rs.3.rs-990197/v1
Autor:
Christina Kalderén, Maurice Michel, Olov A. Wallner, Geoffrey Masuyer, Oliver Mortusewicz, Carlos Benitez-Buelga, Armando Cázares-Körner, Ann-Sofie Jemth, Thomas Helleday, Kumar Sanjiv, Bishoy M. F. Hanna, Olga Loseva, Pål Stenmark, Torkild Visnes, Ulrika Warpman Berglund
Publikováno v:
Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response.
Due to oncogene expression and altered metabolism, reactive oxygen species (ROS) production is augmented in cancer cells resulting in oxidative DNA damage. 8‑oxoguanine (8-oxoG) is one of the most abundant oxidative DNA lesions. This premutagenic l
Publikováno v:
Chemistry–Methods
Autor:
Thomas Helleday, Shruti Regmi, Roni H. G. Wright, Nicholas C.K. Valerie, Hanna Axelsson, Sean G. Rudd, Sabin Llona-Minguez, Helena Almqvist, Pål Stenmark, Evert Homan, Brent D. G. Page, Olov A. Wallner, Martin Scobie, Fredrik Jeppsson, Thomas Lundbäck, Kia Strömberg, Olga Loseva, Jofre Font-Mateu, Rebecka Isaksson, Pawel Baranczewski, Ingrid Almlöf, Anna-Lena Gustavsson, Miguel Beato, Megan Carter, Ann-Sofie Jemth
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications
Nature Communications
With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine metabolism and was recently identified as a rheosta
Autor:
Therese Pham, Kumar Sanjiv, T. Meijer, Jonas Nilsson, Christina Kalderén, Rozbeh Jafari, Fabienne Z. Gaugaz, Torkild Visnes, Annika Lindqvist, Prasad B. Wakchaure, Aleksandr Manoilov, Per Artursson, Gianluca Maddalo, U. Warpman Berglund, Olov A. Wallner, Pawel Baranczewski, V. Nagpal, Azita Rasti, Aljona Saleh, Elisee Wiita, Sean G. Rudd, Ann-Sofie Jemth, Martin Henriksson, Ingrid Almlöf, Helge Gad, Camilla Göktürk, Tobias Koolmeister, Alexey Chernobrovkin, Evert Homan, Thomas Helleday, Vassilis G. Gorgoulis, Lars Bräutigam, Berglind Osk Einarsdottir, Brinton Seashore-Ludlow, Y. Kallberg, Olga Loseva, T-C Lee, Janne Lehtiö, Sanjay R. Borhade, Björn Platzack, Patrick Herr, Anne M. Filppula, Karl S. A. Vallin, Roman A. Zubarev, Ioannis S. Pateras, Martin Scobie, Nicolaas G. M. Schipper
Publikováno v:
Annals of Oncology
Annals of oncology : official journal of the European Society for Medical Oncology
Annals of oncology : official journal of the European Society for Medical Oncology
Background: Previously we showed cancer cells rely on the MTH1 protein to prevent incorporation of otherwise deadly oxidised nucleotides into DNA and we developed MTH1 inhibitors which selectively kill cancer cells. Recently several new and potent in
Autor:
Karl S. A. Vallin, Cynthia B.J. Paulin, Olov A. Wallner, Thomas Helleday, Jiaxi Zhang, Brinton Seashore-Ludlow, Maurice Michel, Martin Scobie, Ulrika Warpman Berglund, Evert Homan, Mattias Hedenström, Torkild Visnes, Andreas Schmidt, Elisee Wiita, Annika Jenmalm-Jensen
Publikováno v:
11642-11656
ACS Omega
ACS Omega, Vol 4, Iss 7, Pp 11642-11656 (2019)
ACS Omega
ACS Omega, Vol 4, Iss 7, Pp 11642-11656 (2019)
Due to a polar or even charged binding interface, DNA-binding proteins are considered extraordinarily difficult targets for development of small-molecule ligands and only a handful of proteins have been targeted successfully to date. Recently, howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a979a2138e18910e81cb3df15c169a00
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164548
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164548
Autor:
Carlos Benitez-Buelga, Christina Kalderén, T. Helleday, Martin Scobie, Ulrika Warpman Berglund, Karthick Marimuthu, Olov A. Wallner, Evert Homan, Kumar Sanjiv, Varshni Rajagopal
Publikováno v:
Cancer Research. 80:4799-4799
In liver, the prodrug proguanil metabolizes into active metabolite cycloguanil, which inhibit folic acid synthesis in plasmodium by inhibiting dihydrofolate reductase (DHFR) enzyme. Proguanil is mostly used in combination with atovaquone as anti-mala
Autor:
Camilla Göktürk, Elisee Wiita, Olga Loseva, Oliver Mortusewicz, Armando Cázares-Körner, Per Artursson, Aleksandr Manoilov, Mikael Altun, Petar Iliev, Ann-Sofie Jemth, Dag Ivanic, Annika Jenmalm Jensen, Roman A. Zubarev, Evert Homan, Azita Rasti, Thomas Helleday, Lang Pan, Istvan Boldogh, Catharina Von Nicolai, Carlos Benitez-Buelga, Tobias Koolmeister, Wenjing Hao, Pawel Baranczewski, Martin Scobie, Bishoy M. F. Hanna, Therese Pham, Ulrika Warpman Berglund, Stella Karsten, Cynthia B.J. Paulin, Geoffrey Masuyer, Antonio Sarno, Pål Stenmark, Torkild Visnes, Juan Astorga-Wells, Christina Kalderén, Olov A. Wallner, Kumar Sanjiv, Xueqing Ba, Maurice Grube, Hans E. Krokan
Publikováno v:
Science
DNA binding as an anti-inflammatory Mice that lack the gene encoding 8-oxoguanine DNA glycosylase 1 (OGG1) show resistance to inflammation. This enzyme binds to sites of oxidative DNA damage and initiates DNA base excision repair. Visnes et al. devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccdba340149cf0ea8e5f4b68a6c3a36
https://hdl.handle.net/11250/2577000
https://hdl.handle.net/11250/2577000