Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins

Autor: Edet Effiong Asanga, Ndifreke Daniel Ekpo, Affiong Asuquo Edeke, Chinedum Martins Ekeleme, Henshaw Uchechi Okoroiwu, Uwem Okon Edet, Ekementeabasi A. Umoh, Nikita Elkanah Umoaffia, Olorunfemi Abraham Eseyin, Ani Nkang, Monday Akpanabiatu, Jude Efiom Okokon, Sylvia Akpotuzor, Bright Asuquo Effiong, MacGeorge Ettaba

Publikováno v: BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-14 (2024)

Abstract Background Chemotherapies target the PfEMP-1 and PfPKG proteins in Plasmodium falciparum, the parasite that causes malaria, in an effort to prevent the disease’s high fatality rate. This work identified the phytochemical components of Nauc

Externí odkaz: https://doaj.org/article/00d10d32a2374c64a953b04c10ad9628

Whole genome sequencing and phylogenetic analysis of SARS-CoV-2 strains isolated during the COVID-19 pandemic in Nigeria.

Autor: Olorunfemi AB; Center for Emerging and Re-emerging Infectious Diseases, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.; Department of Medical Microbiology and Parasitology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria., Suliman SAR; Institute of Endemic Diseases, University of Khartoum, Sudan., Tran TT; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam., Ayorinde B; Molecular Biology & Biotechnology Department, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria.; Central Research Laboratory, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria., Fowora MA; Molecular Biology & Biotechnology Department, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria.; Central Research Laboratory, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria., Iwalokun BA; Molecular Biology & Biotechnology Department, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria.; Central Research Laboratory, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria., Olowe OA; Center for Emerging and Re-emerging Infectious Diseases, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.; Department of Medical Microbiology and Parasitology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria., Opaleye OO; Center for Emerging and Re-emerging Infectious Diseases, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.; Department of Medical Microbiology and Parasitology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria., Osman M; Institute of Endemic Diseases, University of Khartoum, Sudan.; York Biomedical Research Institute, Department of Biology, University of York, Wentworth Way, York YO10 5DD, UK., Salako BL; Molecular Biology & Biotechnology Department, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria.; Central Research Laboratory, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria., Adegbola R; Molecular Biology & Biotechnology Department, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria.; Central Research Laboratory, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Nigeria., Thomas BN; Department of Biomedical Sciences, College of Health Sciences and Technology, Rochester Institute of Technology, Rochester, NY 14623, USA., Pallerla SR; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany.; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Universität Tübingen, Germany., Velavan TP; Vietnamese-German Center for Medical Research (VG-CARE), Hanoi, Vietnam.; Institute of Tropical Medicine, Universitätsklinikum Tübingen, Universität Tübingen, Germany., Ojurongbe O; Center for Emerging and Re-emerging Infectious Diseases, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.; Department of Medical Microbiology and Parasitology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.

Publikováno v: IJID regions [IJID Reg] 2024 Jan 17; Vol. 10, pp. 174-178. Date of Electronic Publication: 2024 Jan 17 (Print Publication: 2024).