Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Olof Stenström"'
Autor:
Simon Birgersson, Johan Morrill, Olof Stenström, Mathias Wiemann, Ulrich Weininger, Pär Söderhjelm, Mikael Akke, Henrik Stålbrand
Publikováno v:
Catalysts, Vol 13, Iss 9, p 1281 (2023)
β-Mannanases hydrolyze β-mannans, important components of plant and microalgae cell walls. Retaining β-mannanases can also catalyze transglycosylation, forming new β-mannosidic bonds that are applicable for synthesis. This study focused on the bl
Externí odkaz:
https://doaj.org/article/6119ba8797c04ddcb3f1db048d4f1ae6
Autor:
Raminta Venskutonytė, Ara Koh, Olof Stenström, Muhammad Tanweer Khan, Annika Lundqvist, Mikael Akke, Fredrik Bäckhed, Karin Lindkvist-Petersson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Imidazole propionate (ImP) produced by gut microbiota has been associated with type 2 diabetes. Here, the authors present crystal structures of the ImP biosynthesis enzyme urocanate reductase in four different states, providing molecular insights int
Externí odkaz:
https://doaj.org/article/51b05c6e4427465ea9174681f26b1d76
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3973 (2023)
Plant hemoglobins, often referred to as phytoglobins, play important roles in abiotic stress tolerance. Several essential small physiological metabolites can be bound to these heme proteins. In addition, phytoglobins can catalyze a range of different
Externí odkaz:
https://doaj.org/article/097f878f7f6e40d6bff3c36c0b1888b9
Autor:
Olof Stenström, Candide Champion, Marc Lehner, Guillaume Bouvignies, Sereina Riniker, Fabien Ferrage
Publikováno v:
Current Opinion in Structural Biology
Current Opinion in Structural Biology, 2022, 77, pp.102459. ⟨10.1016/j.sbi.2022.102459⟩
Current Opinion in Structural Biology, 77
Current Opinion in Structural Biology, 2022, 77, pp.102459. ⟨10.1016/j.sbi.2022.102459⟩
Current Opinion in Structural Biology, 77
Nuclear magnetic resonance (NMR) spin relaxation experi-ments currently probe molecular motions on timescales from picoseconds to nanoseconds. The detailed interpretation of these motions in atomic detail benefits from complementarity with the result
Publikováno v:
RSC Chemical Biology
Biochemical signaling is mediated by complexes between macromolecular receptors and their ligands, with the duration of the signal being directly related to the lifetime of the ligand–receptor complex. In the field of drug design, the recognition t
Autor:
Esko Oksanen, Olof Stenström, Ulf J. Nilsson, Mikael Akke, Francesco Manzoni, Maria Luisa Verteramo, Majda Misini Ignjatović, Octav Caldararu, Derek T. Logan, Ulf Ryde, Hakon Leffler, Martin A. Olsson
Publikováno v:
Journal of the American Chemical Society; 141(5), pp 2012-2026 (2019)
Understanding the driving forces underlying molecular recognition is of fundamental importance in chemistry and biology. The challenge is to unravel the binding thermodynamics into separate contributions and to interpret these in molecular terms. Ent
Autor:
Muhammad Tanweer Khan, Fredrik Bäckhed, Karin Lindkvist-Petersson, Raminta Venskutonytė, Annika Lundqvist, Mikael Akke, Ara Koh, Olof Stenström
Publikováno v:
Nature Communications
Venskutonytė, R, Koh, A, Stenström, O, Khan, M T, Lundqvist, A, Akke, M, Bäckhed, F & Lindkvist-Petersson, K 2021, ' Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production ', Nature Communications, vol. 12, no. 1 . https://doi.org/10.1038/s41467-021-21548-y
Nature Communications 12(1), 1347 (2021). doi:10.1038/s41467-021-21548-y
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Venskutonytė, R, Koh, A, Stenström, O, Khan, M T, Lundqvist, A, Akke, M, Bäckhed, F & Lindkvist-Petersson, K 2021, ' Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production ', Nature Communications, vol. 12, no. 1 . https://doi.org/10.1038/s41467-021-21548-y
Nature Communications 12(1), 1347 (2021). doi:10.1038/s41467-021-21548-y
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications 12(1), 1347 (2021). doi:10.1038/s41467-021-21548-y
The human microbiome can produce metabolites that modulate insulin signaling. Type 2 diabetes patients have increased circulating concentrations of the microbially produced
The human microbiome can produce metabolites that modulate insulin signaling. Type 2 diabetes patients have increased circulating concentrations of the microbially produced
Autor:
Kristoffer Peterson, Rohit Kumar, Prashant R Verma, Maria Håkansson, Barbro Kahl-Knutsson, Hakon Leffler, Derek T. Logan, Fredrik Zetterberg, Ulf J. Nilsson, Mikael Akke, Olof Stenström, Priya Verma
Publikováno v:
Journal of medicinal chemistry 61(3), 1164-1175 (2018). doi:10.1021/acs.jmedchem.7b01626
Journal of medicinal chemistry 61(3), 1164 - 1175 (2018). doi:10.1021/acs.jmedchem.7b01626
Symmetrical and asymmetrical fluorinated phenyltriazolyl-thiodigalactoside derivatives have been synthesized and evaluated as inhibitors of galectin-1 and
Symmetrical and asymmetrical fluorinated phenyltriazolyl-thiodigalactoside derivatives have been synthesized and evaluated as inhibitors of galectin-1 and
Autor:
Christopher T. Öberg, Hakon Leffler, Oskar Aurelius, Mikael Akke, Derek T. Logan, Maria Håkansson, Ulf J. Nilsson, Olof Engström, Anders Sundin, Ann-Louise Noresson, Olof Stenström
Publikováno v:
Chemical Science. 9:1014-1021
We investigated galectin-3 binding to 3-benzamido-2-O-sulfo-galactoside and -thiodigalactoside ligands using a combination of site-specific mutagenesis, X-ray crystallography, computational approaches, and binding thermodynamics measurements. The res
Autor:
Torbjörn Drakenberg, Derek T. Logan, Robert Lizatović, Ingemar André, Oskar Aurelius, Olof Stenström, Mikael Akke
Publikováno v:
Structure (London, England : 1993). 24(6)
Protein conformational switches have many useful applications but are difficult to design rationally. Here we demonstrate how the isoenergetic energy landscape of higher-order coiled coils can enable the formation of an oligomerization switch by inse