Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

Autor: You Xu, Laure Harinck, Abhijeet G. Lokras, Per Gerde, Ewa Selg, Carl-Olof Sjöberg, Henrik Franzyk, Aneesh Thakur, Camilla Foged

Publikováno v: Xu, Y, Harinck, L, Lokras, A G, Gerde, P, Selg, E, Sjöberg, C-O, Franzyk, H, Thakur, A & Foged, C 2022, ' Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles ', International Journal of Pharmaceutics, vol. 621, 121758 . https://doi.org/10.1016/j.ijpharm.2022.121758

Thermostable dry powder inhaler (DPI) formulations with high aerosol performance are attractive inhalable solid dosage forms for local treatment of inflammatory lung diseases. We recently demonstrated that lipidoid-polymer hybrid nanoparticles (LPNs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c7136011c1b8d5b0ff6471a68f05d8
https://pubmed.ncbi.nlm.nih.gov/35483619

11C-carbonylation reactions using gas–liquid segmented microfluidics

Autor: Christer Halldin, Johan Ulin, Carl-Olof Sjöberg, Lars Farde, Magnus Schou, Kenneth Dahl

Publikováno v: RSC Advances. 5:88886-88889

A novel gas–liquid segmented microfluidic platform has been developed. The Pd-mediated 11C-carbonylation reaction proceeds smoothly on this platform and good to excellent radiochemical conversions (RCC) were observed. Twelve compounds were successf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::532eb61689040c317e60b95da2aae22a
https://doi.org/10.1039/c5ra20646d

Dry Powder Inhalation Exposures of the Endotracheally Intubated Rat Lung, Ex Vivo and In Vivo: The Pulmonary Pharmacokinetics of Fluticasone Furoate

Autor: Carl-Olof Sjöberg, Fernando Acevedo, Ewa Selg, Per Gerde, Åke Ryrfeldt, Pär Ewing

Publikováno v: Journal of Aerosol Medicine and Pulmonary Drug Delivery. 26:181-189

The isolated perfused rat lung (IPL) is a suitable model for studying lung-specific pharmacokinetics (PK) of inhaled drugs. So far, little has been known, however, whether the PK measured in the ex vivo organ corresponds to the PK measured in similar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653d651f04287400f7d9b501dba32ab5
https://doi.org/10.1089/jamp.2012.0971

Sensitization to food and airborne allergens in children with atopic dermatitis followed up to 7 years of age

Autor: Olof Sjöberg, Dan Gustafsson, Tony Foucard

Publikováno v: Pediatric Allergy and Immunology. 14:448-452

Previously we investigated the eczema prognosis and the risk of developing allergic asthma and rhinitis in a cohort of 94 children with atopic dermatitis. In this second study on the same cohort we address the development of sensitization to foods an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6097b389fee5a7dd66ba3c75cb299c8e
https://doi.org/10.1046/j.0905-6157.2003.00093.x

Sensitization to airborne and food allergens in Reykjavik (Iceland) and Uppsala (Sweden) - a comparative study

Autor: David Gislason, T. Gislason, L. H. M. Elfman, Christer Janson, Olof Sjöberg, Gunnar Boman, Eythor Björnsson

Publikováno v: Allergy. 54:1160-1167

Background: The aim of this study was to compare the prevalence of atopic sensitization and possible risk factors for allergies in two ethnically similar but geographically widely separated urban populations. Methods: Data from two centers of the Eur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8505e77ed56dac65943b0feecdf03d3a
https://doi.org/10.1034/j.1398-9995.1999.00093.x