Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Olof Rådmark"'
Autor:
Ana Lukic, Jie Ji, Helena Idborg, Bengt Samuelsson, Lena Palmberg, Susanne Gabrielsson, Olof Rådmark
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 9, Pp 1659-1669 (2016)
Leukotrienes (LTs) play major roles in lung immune responses, and LTD4 is the most potent agonist for cysteinyl LT1, leading to bronchoconstriction and tissue remodeling. Here, we studied LT crosstalk between myeloid cells and pulmonary epithelial ce
Externí odkaz:
https://doaj.org/article/3aada5d318194fd291e3f2d9e19096b9
Autor:
Ramakrishnan B Kumar, Lin Zhu, Helena Idborg, Olof Rådmark, Per-Johan Jakobsson, Agnes Rinaldo-Matthis, Hans Hebert, Caroline Jegerschöld
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152116 (2016)
An important step in the production of inflammatory mediators of the leukotriene family is the Ca2+ mediated recruitment of 5 Lipoxygenase (5LO) to nuclear membranes. To study this reaction in vitro, the natural membrane mimicking environment of nano
Externí odkaz:
https://doaj.org/article/755a0776bee44b2f8363b8b7efc427c3
Autor:
Olof Rådmark, Bengt Samuelsson
Publikováno v:
Journal of Lipid Research, Vol 50, Iss , Pp S40-S45 (2009)
5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in ath
Externí odkaz:
https://doaj.org/article/379a64b6483840d5b04708b63101d60f
Autor:
Marius, Kreiß, Julia H, Oberlis, Sabine, Seuter, Iris, Bischoff-Kont, Duran, Sürün, Dominique, Thomas, Tamara, Göbel, Tobias, Schmid, Olof, Rådmark, Ralf P, Brandes, Robert, Fürst, Ann-Kathrin, Häfner, Dieter, Steinhilber
Publikováno v:
Biochemical pharmacology. 203
Human 5-lipoxygenase (5-LO) is the key enzyme of leukotriene biosynthesis, mostly expressed in leukocytes and thus a crucial component of the innate immune system. In this study, we show that 5-LO, besides its canonical function as an arachidonic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3e0976a0be89ac1b7582fc9605c2abd
https://pubmed.ncbi.nlm.nih.gov/35878796
https://pubmed.ncbi.nlm.nih.gov/35878796
Autor:
Bengt Samuelsson, Cristina Gómez, Craig E. Wheelock, Casper J. E. Wahlund, Ana Lukic, Olof Rådmark, Daniel Brodin, Susanne Gabrielsson
Publikováno v:
Cancer Letters. 444:1-8
Tumor-derived exosomes can modulate the cancer microenvironment and induce metastatic spread. Exosomes may carry enzymes for leukotriene (LT) biosynthesis, but the role of exosomal LTs has not been studied in cancer. We isolated exosomes and malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab35965f450dab3030960e7ac71eedfc
https://doi.org/10.1016/j.canlet.2018.11.033
https://doi.org/10.1016/j.canlet.2018.11.033
Autor:
Ann-Kathrin Häfner, Ulrike Garscha, Devaraj Basavarajappa, Bengt Samuelsson, Duran Sürün, Stella Uebbing, Friederike Scholl, Olof Rådmark, Beatrix Suess, Oliver Werz, Marius Kreiß, Dieter Steinhilber
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(2)
The miRNA biogenesis is tightly regulated to avoid dysfunction and consequent disease development. Here, we describe modulation of miRNA processing as a novel noncanonical function of the 5-lipoxygenase (5-LO) enzyme in monocytic cells. In differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f874caf2b67993fbb4f25d945dff1971
https://pubmed.ncbi.nlm.nih.gov/33205517
https://pubmed.ncbi.nlm.nih.gov/33205517
Autor:
Craig E. Wheelock, Bengt Samuelsson, Pia Larssen, Olof Rådmark, Alexander Fauland, Susanne Gabrielsson, Ana Lukic
Publikováno v:
The FASEB Journal. 31:4370-4381
M1 and M2 activated macrophages (Mϕs) have different roles in inflammation. Because pathogens may first encounter resting cells, we investigated lipid mediator profiles prior to full activation. Human monocytes were differentiated with granulocyte M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39ccad78238ae6b5be6c7a74a6d315d
https://doi.org/10.1096/fj.201700319r
https://doi.org/10.1096/fj.201700319r
Autor:
Monica Mittal, Navisraj Balagunaseelan, Craig E. Wheelock, Agnes Rinaldo-Matthis, Alexander Fauland, Olof Rådmark, Jesper Z. Haeggström, Mahmudul Hasan
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2099-2111
Background A 12-lipoxygenase in zebra fish (zf12-LOX) was found to be required for normal embryonic development and LOXs are of great interest for targeted drug designing. In this study, we investigate the structural-functional aspects of zf12-LOX in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32d2517c2b8886c36babd5b37d7c520
https://doi.org/10.1016/j.bbagen.2017.05.015
https://doi.org/10.1016/j.bbagen.2017.05.015
Autor:
Ulrike Garscha, Oliver Werz, Silke Rummler, Christina Weinigel, Jana Gerstmeier, Olof Rådmark
Publikováno v:
The FASEB Journal. 30:276-285
5-Lipoxygenase (5-LO) catalyzes the initial steps in the biosynthesis of proinflammatory leukotrienes. Upon cell activation, 5-LO translocates to the nuclear membrane where arachidonic acid is transferred by 5-LO-activating protein (FLAP) to 5-LO for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00da839e4d05d046353d0d78a2387b51
https://doi.org/10.1096/fj.15-278010
https://doi.org/10.1096/fj.15-278010
Autor:
Birger Christensson, Bernd L. Sorg, Olof Rådmark, Yilmaz Mahshid, Magnus Björkholm, Birgitta Sander, Hans-Erik Claesson, Vildan Dincbas-Renqvist, Duran Sürün, Stavroula Markoutsa
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 100:33-40
The key enzyme in leukotriene (LT) biosynthesis is 5-lipoxygenase (5-LO), which is expressed in myeloid cells and in B lymphocytes. There are three phosphorylation sites on 5-LO (Ser271, Ser523 and Ser663). Protein kinase A (PKA) phosphorylates 5-LO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b10adb22a74b242e50f73cc822d85c
https://doi.org/10.1016/j.plefa.2015.06.003
https://doi.org/10.1016/j.plefa.2015.06.003