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Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia.

Autor: Monteith AJ; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Microbiology, University of Tennessee, Knoxville, Tennessee., Ramsey HE; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee., Silver AJ; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee., Brown D; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Greenwood D; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee., Smith BN; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee., Wise AD; Department of Microbiology, University of Tennessee, Knoxville, Tennessee., Liu J; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina., Olmstead SD; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Watke J; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Arrate MP; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Gorska AE; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Fuller L; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Locasale JW; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina., Stubbs MC; Incyte Corporation, Wilmington, Delaware., Rathmell JC; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Savona MR; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Publikováno v: Cancer research [Cancer Res] 2024 Apr 01; Vol. 84 (7), pp. 1101-1114.