BRCA2 Mutations in 154 Finnish Male Breast Cancer Patients

Autor: Kirsi Syrjäkoski, Tuula Kuukasjärvi, Kati Waltering, Karin Haraldsson, Anssi Auvinen, Åke Borg, Tommi Kainu, Olli-P Kallioniemi, Pasi A. Koivisto

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 5, Pp 541-545 (2004)

The etiology and pathogenesis of male breast cancer (MBC) are poorly known. This is due to the fact that the disease is rare, and large-scale genetic epidemiologic studies have been difficult to carry out. Here, we studied the frequency of eight recu

Externí odkaz: https://doaj.org/article/0ec309226fc14aeeaeead309f6e3816f

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines

Autor: Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Päivi Östling, Olli P. Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtiö, Mattias Vesterlund, Rozbeh Jafari

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Childhood acute lymphoblastic leukemia is characterised by a range of genetic aberrations. Here, the authors use multi-omics profiling of ALL cell lines to connect molecular phenotypes and drug responses to provide an interactive resource of drug sen

Externí odkaz: https://doaj.org/article/9c69031e6a7f4af09b4fad9d64e4c2b5

Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose–response data

Autor: Päivi Östling, Khalid Saeed, Bychkov Dmitrii, Potdar Swapnil, Saarela Jani, Olli-P. Kallioniemi, Tero Aittokallio, John Patrick Mpindi, Krister Wennerberg

Publikováno v: Bioinformatics

Motivation: Most data analysis tools for high-throughput screening (HTS) seek to uncover interesting hits for further analysis. They typically assume a low hit rate per plate. Hit rates can be dramatically higher in secondary screening, RNAi screenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff787fbc079acc9408460faa638e8f3
https://doi.org/10.1093/bioinformatics/btv455

Are data from different gene expression microarray platforms comparable?

Autor: Anna-Kaarina Järvinen, Olli-P. Kallioniemi, Sampsa Hautaniemi, Outi Monni, Henrik Edgren, Janna Saarela, Petri Auvinen

Publikováno v: Järvinen, A-K, Hautaniemi, S, Edgren, H, Auvinen, P, Saarela, J, Kallioniemi, O & Monni, O 2004, ' Are data from different gene expression microarray platforms comparable? ', Genomics, vol. 83, no. 6, pp. 1164-1168 . https://doi.org/10.1016/j.ygeno.2004.01.004

Many commercial and custom-made microarray formats are routinely used for large-scale gene expression surveys. Here, we sought to determine the level of concordance between microarray platforms by analyzing breast cancer cell lines with in situ synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110d4d2ae2ebf33afce379e787adbc17
https://doi.org/10.1016/j.ygeno.2004.01.004

New Paraoxonase 1 Polymorphism I102V and the Risk of Prostate Cancer in Finnish Men

Autor: Johanna Schleutker, Tomi-Pekka Tuomainen, Eija H. Seppälä, Pekka Uimari, Mika P. Matikainen, Terho Lehtimäki, Jari Kaikkonen, Olli-P. Kallioniemi, Anna Hakkarainen, Marja Marchesani, Jukka T. Salonen, Eero Pukkala

Publikováno v: Marchesani, M, Hakkarainen, A, Tuomainen, T-P, Kaikkonen, J, Pukkala, E, Uimari, P, Seppälä, E, Matikainen, M, Kallioniemi, O, Schleutker, J, Lehtimäki, T & Salonen, J 2003, ' New paraoxonase 1 polymorphism I102V and the risk of prostate cancer in Finnish men ', Journal of the National Cancer Institute, vol. 95, no. 11, pp. 812-818 . https://doi.org/10.1093/jnci/95.11.812
University of Helsinki

Background: Human serum paraoxonase eliminates carcinogenic lipid-soluble radicals. Because expression of the main human paraoxonase gene PON1 varies widely in humans, certain PON1 polymorphisms might be associated with increased risks of cancer. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df538aa6c2422b75be5292fcc16e6509
https://doi.org/10.1093/jnci/95.11.812