Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Olli T. Pentikäinen"'
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract The performance of molecular docking can be improved by comparing the shape similarity of the flexibly sampled poses against the target proteins’ inverted binding cavities. The effectiveness of these pseudo-ligands or negative image-based
Externí odkaz:
https://doaj.org/article/3cd64d458d6d431f9c13a1b837e2cf8f
Autor:
Joanna Małolepsza, Aleksandra Marchwicka, Remigiusz A. Serwa, Sanna P. Niinivehmas, Olli T. Pentikäinen, Edyta Gendaszewska-Darmach, Katarzyna M. Błażewska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 940-951 (2022)
Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT in
Externí odkaz:
https://doaj.org/article/47e9fe0a13f242da98a9cbc1518f4bee
Autor:
Risto O. Juvonen, Mira Ahinko, Elmeri M. Jokinen, Juhani Huuskonen, Hannu Raunio, Olli T. Pentikäinen
Publikováno v:
ACS Omega, Vol 6, Iss 17, Pp 11286-11296 (2021)
Externí odkaz:
https://doaj.org/article/d98e760f25234a2f80683f7c9d6217d5
Autor:
Elmeri M. Jokinen, Miika Niemeläinen, Sami T. Kurkinen, Jukka V. Lehtonen, Sakari Lätti, Pekka A. Postila, Olli T. Pentikäinen, Sanna P. Niinivehmas
Publikováno v:
Molecules, Vol 28, Iss 8, p 3420 (2023)
Molecular docking is a key method used in virtual screening (VS) campaigns to identify small-molecule ligands for drug discovery targets. While docking provides a tangible way to understand and predict the protein-ligand complex formation, the dockin
Externí odkaz:
https://doaj.org/article/def2c2d7cd9d43a18836191ef31d6b7a
Autor:
John Marshal Jayaraj, Muralidharan Jothimani, Chella Perumal Palanisamy, Olli T. Pentikäinen, Mehboobali Pannipara, Abdullah G. Al-Sehemi, Karthikeyan Muthusamy, Krishnasamy Gopinath
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
COVID-19 is more virulent and challenging to human life. In India, the Ministry of AYUSH recommended some strategies through Siddha, homeopathy, and other methods to effectively manage COVID-19 (Guidelines for AYUSH Clinical Studies in COVID-19, 2020
Externí odkaz:
https://doaj.org/article/ca353293518c4e87bceffef27e67304d
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The COVID-19 pandemic, caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a severe global health crisis now. SARS-CoV-2 utilizes its Spike protein receptor-binding domain (S-protein) to invade human cell through binding
Externí odkaz:
https://doaj.org/article/12d67effe17b41ff83ffc64f025b4a16
Autor:
Sanna Rauhamäki, Pekka A. Postila, Sakari Lätti, Sanna Niinivehmas, Elina Multamäki, Klaus R. Liedl, Olli T. Pentikäinen
Publikováno v:
ACS Omega, Vol 3, Iss 6, Pp 6259-6266 (2018)
Externí odkaz:
https://doaj.org/article/a43423e0d23042b8b28d1c60787b00b8
Autor:
Sanna Niinivehmas, Pekka A. Postila, Sanna Rauhamäki, Elangovan Manivannan, Sami Kortet, Mira Ahinko, Pasi Huuskonen, Niina Nyberg, Pasi Koskimies, Sakari Lätti, Elina Multamäki, Risto O. Juvonen, Hannu Raunio, Markku Pasanen, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 743-754 (2018)
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HS
Externí odkaz:
https://doaj.org/article/ca9ca7ff4f1a4f61961e932f9fb13641
Autor:
Sanna Niinivehmas, Olli T. Pentikäinen
Publikováno v:
Molecules, Vol 26, Iss 17, p 5142 (2021)
Steroid hormones play an essential role in a wide variety of actions in the body, such as in metabolism, inflammation, initiating and maintaining sexual differentiation and reproduction, immune functions, and stress response. Androgen, aromatase, and
Externí odkaz:
https://doaj.org/article/e232562bf6544249a5e6a6fc1e59bd7a
Autor:
Jonne Seppälä, Rafael C. Bernardi, Tatu J. K. Haataja, Maarit Hellman, Olli T. Pentikäinen, Klaus Schulten, Perttu Permi, Jari Ylänne, Ulla Pentikäinen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Cells’ ability to sense mechanical cues in their environment is crucial for fundamental cellular processes, leading defects in mechanosensing to be linked to many diseases. The actin cross-linking protein Filamin has an important role in t
Externí odkaz:
https://doaj.org/article/19baf53cadc947c297dabc4e0149c6e8