Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Olli Törmäkangas"'
Autor:
Avainash Kumar, Olli Törmäkangas, Susanta Samajdar, AB Aravind, Suraj Tgore, Subhendu Mukherjee, Nirbhay Kumar Tiwari, Girish Daginakatte, Anu Moilanen, Raghurami B Reddy, Laura Ravanti, Thomas Antony, Elina Mattila, Mari Björkman, Janith Mary Maben, Shekar Chelur, Mahaboobi Jaleel, Nvm Rao Bandaru, Akhila Srinivas, Indu Bansal, DS Samiulla, Rakesh P. Nankar, Kavitha Nellore, Chandrasekhar Abbineni, Chandranath D. Naik, Sanjeev Giri, Murali Ramachandra, Gerd Wohlfahrt, Naveen Kumar, Sivapriya Marappan
Publikováno v:
Cancer Research. 80:1754-1754
Background: Inhibition of Bromodomain and extra-terminal (BET) family proteins by small molecules is actively being pursued as a therapeutic strategy in the clinics. Targeted protein degradation is an emerging therapeutic modality that has shown init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dac44ba72bb66c0059e6c8a84001aa4d
https://doi.org/10.1158/1538-7445.am2020-1754
https://doi.org/10.1158/1538-7445.am2020-1754
Autor:
Karthikeyan Narasingapuram Arumugam, Jwala Nagaraj, DS Samiulla, Murali Ramachandra, Rajendra K. Palakurthy, Rajeev Goswami, Olli Törmäkangas, Anirudha Lakshminarasimhan, Narasimha Rao Krishnamurthy, Gerd Wohlfahrt, Anu Moilanen, Subhendu Mukherjee, Mahaboobi Jaleel, Anita R. Chacko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5309-5314
Hepsin, a type II transmembrane serine protease, is upregulated in prostate cancer and known to be involved in the progression of metastasis. Here we report a structure-guided approach, which resulted in the discovery of 2-aryl/pyridin-2-yl-1H-indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11309c3bb66ab52d9329fa0c0ba4c60
https://doi.org/10.1016/j.bmcl.2015.09.042
https://doi.org/10.1016/j.bmcl.2015.09.042
Autor:
Reetta Riikonen, Eija Aho, Jorma J. Palvimo, Laura Ravanti, Gerd Wohlfahrt, Olli Törmäkangas, Riikka Oksala, Anu-Maarit Moilanen, Pirjo Nykänen, Pekka Kallio
Publikováno v:
Scientific Reports
Article
Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain the addiction. K
Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain the addiction. K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552d0a9f21c0f19ca277de470a4ee27f
https://doi.org/10.1038/srep12007
https://doi.org/10.1038/srep12007