ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study

Autor: Ari-Pekka J. Huovila, Niku Airla, Leena Kytömäki, Juhani T. Soini, Jussi Mikkelsson, Terho Lehtimäki, Pekka J. Karhunen, Markus Perola, Mika Kähönen, Erkki Ilveskoski, Jussi Hernesniemi, Rainer Zeitlin, Olli Jaakkola, Mari Levula, Seppo T. Nikkari, Juha-Pekka Salenius, Jyrki Parkkinen, Markku Pelto-Huikko, Niku Oksala, Reijo Laaksonen, Otso Järvinen

Publikováno v: Annals of Medicine
Annals of Medicine; Vol 41

Previously, we scanned all 23,000 human genes for differential expression between normal and atherosclerotic tissues and found the involvement of ADAM8.We investigated the expression of ADAM8 mRNA and protein level in human atherosclerotic tissues an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a9e6cebbb0b75c967a4a3d52d35954

Serum matrix metalloproteinase‐9 and venous bypass graft occlusion

Autor: Vesa Virtanen, Vilho Limnell, Anne Kalela, Janne Aittoniemi, Olli Jaakkola, Seppo T. Nikkari, Terho Lehtimäki

Publikováno v: Scandinavian Journal of Clinical and Laboratory Investigation. 66:7-14

The primary results after coronary artery bypass grafting are good, but early clinical events as a result of graft occlusion are still a problem. Early occlusions are thought to be due to thrombosis or fibrointimal hyperplasia superimposed by thrombo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1460799ddbdfa9ccdf949e9b22eba063
https://doi.org/10.1080/00365510500402125

Myeloperoxidase gene variation and coronary flow reserve in young healthy men

Autor: Juhani Knuuti, Riikka Mäkelä, Pirjo Nuutila, Tuula Janatuinen, Reijo Laaksonen, Risto Vesalainen, Terho Lehtimäki, Olli Jaakkola

Publikováno v: Journal of Biomedical Science. 11:59-64

Chronic inflammation may lead to endothelial dysfunction, which manifests as an impaired coronary reactivity. Impairment in coronary flow reserve (CFR), preceding the clinical symptoms of coronary artery disease, can be measured noninvasively by posi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3ff0d416bdf6caa7e1a5f7f0151bcd
https://doi.org/10.1007/bf02256549

Oestrogen receptor gene variation is a determinant of coronary reactivity in healthy young men

Autor: Juha Laakso, Risto Vesalainen, Olli Jaakkola, Juhani Knuuti, Kari M. Mattila, Reijo Laaksonen, Timo Koivula, Pirjo Nuutila, Terho Lehtimäki, Tuula Janatuinen

Publikováno v: European Journal of Clinical Investigation. 32:400-404

Background Oxidised low-density lipoprotein (ox-LDL) is a determinant of impaired coronary function and oestrogens inhibit its formation probably throughout genetically-variable oestrogen receptor 1 (ESR1) in artery wall. We hypothesized that the ESR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd31b29be4a75c1104098d747ad8deb0
https://doi.org/10.1046/j.1365-2362.2002.01010.x

A 12 MHz micromechanical bulk acoustic mode oscillator

Autor: Tuomas Lamminmäki, Aarne Oja, Hannu Kattelus, Pekka Rantakari, Heikki Seppä, Ilkka Tittonen, Olli Jaakkola, Jyrki Kiihamäki, Tomi Mattila

Publikováno v: Mattila, T, Kiihamäki, J, Lamminmäki, T, Jaakkola, O, Rantakari, P, Oja, A, Seppä, H, Kattelus, H & Tittonen, I 2002, ' A 12 MHz micromechanical bulk acoustic mode oscillator ', Sensors and Actuators A: Physical, vol. 101, no. 1-2, pp. 1-9 . https://doi.org/10.1016/S0924-4247(02)00204-2

We demonstrate a bulk acoustic mode silicon micromechanical resonator with the first eigen frequency at 12 MHz and the quality factor 180 000. Electrostatic coupling to the mechanical motion is shown to be feasible using a high bias voltage across a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd7077e1f70a4c5d7e80ed59807b6d6
https://doi.org/10.1016/S0924-4247(02)00204-2