Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Olli H. LAITINEN"'
Autor:
Marja I. Roslund, Noora Nurminen, Sami Oikarinen, Riikka Puhakka, Mira Grönroos, Leena Puustinen, Laura Kummola, Anirudra Parajuli, Ondřej Cinek, Olli H. Laitinen, Heikki Hyöty, Aki Sinkkonen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract A resilient immune system is characterized by its capacity to respond appropriately to challenges, such as infections, and it is crucial in vaccine response. Here we report a paired randomized intervention-control trial in which we evaluated
Externí odkaz:
https://doaj.org/article/c2f95abb7c8540518ddcbee6e4598bfb
Publikováno v:
People and Nature, Vol 6, Iss 3, Pp 1078-1095 (2024)
Abstract Evidence suggests that soil microorganisms, to which humans have been exposed throughout our evolutionary history, were essential for the evolution of the human gut microbiome and immunological resilience. In recent decades, gut microbial di
Externí odkaz:
https://doaj.org/article/b423e1641e9042efa65519333597cc50
Autor:
Mika Saarenpää, Marja I. Roslund, Noora Nurminen, Riikka Puhakka, Laura Kummola, Olli H. Laitinen, Heikki Hyöty, Aki Sinkkonen
Publikováno v:
Environment International, Vol 187, Iss , Pp 108705- (2024)
According to the hygiene and biodiversity hypotheses, frequent exposure to environmental microbiota, especially through soil contact, diversifies commensal microbiota, enhances immune modulation, and ultimately lowers the risk of immune-mediated dise
Externí odkaz:
https://doaj.org/article/15cc75715d154508a4f5053fa1dcb5bb
Autor:
Laura Kummola, Martín I. González-Rodríguez, Pertti Marnila, Noora Nurminen, Tanja Salomaa, Lotta Hiihtola, Iida Mäkelä, Olli H. Laitinen, Heikki Hyöty, Aki Sinkkonen, Ilkka S. Junttila
Publikováno v:
BMC Immunology, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Background . Lack of exposure to the natural microbial diversity of the environment has been linked to dysregulation of the immune system and numerous noncommunicable diseases, such as allergies and autoimmune disorders. Our previous studies
Externí odkaz:
https://doaj.org/article/b2b6cf02b6834c558fb2ecdf7767f75f
Autor:
Marja I. Roslund, Anirudra Parajuli, Nan Hui, Riikka Puhakka, Mira Grönroos, Laura Soininen, Noora Nurminen, Sami Oikarinen, Ondřej Cinek, Lenka Kramná, Anna-Mari Schroderus, Olli H. Laitinen, Tuure Kinnunen, Heikki Hyöty, Aki Sinkkonen
Publikováno v:
Data in Brief, Vol 47, Iss , Pp 109003- (2023)
The metagenomic data presented in this article are related to the published research of “A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytok
Externí odkaz:
https://doaj.org/article/ffa884efd9794421a15b18bb8d43c49e
Autor:
Marja I. Roslund, Anirudra Parajuli, Nan Hui, Riikka Puhakka, Mira Grönroos, Laura Soininen, Noora Nurminen, Sami Oikarinen, Ondřej Cinek, Lenka Kramná, Anna-Mari Schroderus, Olli H. Laitinen, Tuure Kinnunen, Heikki Hyöty, Aki Sinkkonen, Damiano Cerrone, Anna Luukkonen, Iida Mäkelä, Mika Saarenpää, Juho Rajaniemi
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 242, Iss , Pp 113900- (2022)
Background: According to the biodiversity hypothesis of immune-mediated diseases, lack of microbiological diversity in the everyday living environment is a core reason for dysregulation of immune tolerance and – eventually – the epidemic of immun
Externí odkaz:
https://doaj.org/article/caa5e5cdfcc4431ab2b87f7ce65cba9f
Autor:
Olli H. Laitinen, Tanja P. Kuusela, Sampo Kukkurainen, Anssi Nurminen, Aki Sinkkonen, Vesa P. Hytönen
Publikováno v:
BMC Ecology and Evolution, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background Avidins are biotin-binding proteins commonly found in the vertebrate eggs. In addition to streptavidin from Streptomyces avidinii, a growing number of avidins have been characterized from divergent bacterial species. However, a sy
Externí odkaz:
https://doaj.org/article/fe22dd61e767493695017f4ca9112539
Autor:
Vili Lampinen, Suvi Heinimäki, Olli H. Laitinen, Marko Pesu, Minna M. Hankaniemi, Vesna Blazevic, Vesa P. Hytönen
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Virus-like particle (VLP) vaccines have recently emerged as a safe and effective alternative to conventional vaccine technologies. The strong immunogenic effects of VLPs can be harnessed for making vaccines against any pathogen by
Externí odkaz:
https://doaj.org/article/ffa2db15f11a40eca0c3dce791cdb813
Autor:
Martín Ignacio González‐Rodríguez, Noora Nurminen, Laura Kummola, Olli H. Laitinen, Sami Oikarinen, Anirudra Parajuli, Tanja Salomaa, Iida Mäkelä, Marja I. Roslund, Aki Sinkkonen, Heikki Hyöty, Ilkka S. Junttila, for the ADELE Research Group
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract Introduction The hygiene hypothesis suggests that decrease in early life infections due to increased societal‐level hygiene standards subjects one to allergic and autoimmune diseases. In this report, we have studied the effect of sterilize
Externí odkaz:
https://doaj.org/article/8f6a50156c51473e956305a11c714fce
Autor:
Marja I. Roslund, Riikka Puhakka, Noora Nurminen, Sami Oikarinen, Nathan Siter, Mira Grönroos, Ondřej Cinek, Lenka Kramná, Ari Jumpponen, Olli H. Laitinen, Juho Rajaniemi, Heikki Hyöty, Aki Sinkkonen, Damiano Cerrone, Nan Hui, Iida Mäkelä, Anirudra Parajuli, Mika Saarenpää, Laura Soininen, Yan Sun, Heli K. Vari
Publikováno v:
Environment International, Vol 157, Iss , Pp 106811- (2021)
Background: In modern urban environments children have a high incidence of inflammatory disorders, including allergies, asthma, and type 1 diabetes. The underlying cause of these disorders, according to the biodiversity hypothesis, is an imbalance in
Externí odkaz:
https://doaj.org/article/7afe46d7bece4b6b8b96a3f9ecfc37c6