Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Olli Dufva"'
Autor:
Jun Dai, Shuyu Zheng, Matías M. Falco, Jie Bao, Johanna Eriksson, Sanna Pikkusaari, Sofia Forstén, Jing Jiang, Wenyu Wang, Luping Gao, Fernando Perez-Villatoro, Olli Dufva, Khalid Saeed, Yinyin Wang, Ali Amiryousefi, Anniina Färkkilä, Satu Mustjoki, Liisa Kauppi, Jing Tang, Anna Vähärautio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Exploring non-genetic evolution of cell states during cancer treatments has become attainable by recent advances in lineage-tracing methods. However, transcriptional changes that drive cells into resistant fates may be subtle, necessitating
Externí odkaz:
https://doaj.org/article/cb6fd31ba8b2481198015e55a8c83a4c
Autor:
Ida Vänttinen, Sari Kytölä, Olli Dufva, Monica Hellesøy, Stein-Erik Gullaksen, Tanja Ruokoranta, Oscar Brück, Sanna Siitonen, Pia Ettala, Marja Pyörälä, Johanna Rimpilainen, Timo Siitonen, Bjorn Tore Gjertsen, Caroline Heckman, Heikki Kuusanmäki, Mika Kontro
Publikováno v:
HemaSphere, Vol 7, p e7849686 (2023)
Externí odkaz:
https://doaj.org/article/05ce49b0486b476d9b9a10b96be99af1
Autor:
Sanna Timonen, Vanessa Rebecca Gasparini, Ella Piekkari, Olli Dufva, Shady Awad, Yevhen Akimov, Jana von Jan, Till Braun, Aleksandr Ianevski, Matti Kankainen, Jay Klievink, Marco Herling, Tero Aittokallio, Satu Mustjoki
Publikováno v:
HemaSphere, Vol 7, p e0412416 (2023)
Externí odkaz:
https://doaj.org/article/9484c3ef8db5473d9347097be160c21a
Autor:
Jani Huuhtanen, Henna Kasanen, Katriina Peltola, Tapio Lönnberg, Virpi Glumoff, Oscar Brück, Olli Dufva, Karita Peltonen, Johanna Vikkula, Emmi Jokinen, Mette Ilander, Moon Hee Lee, Siru Mäkelä, Marta Nyakas, Bin Li, Micaela Hernberg, Petri Bono, Harri Lähdesmäki, Anna Kreutzman, Satu Mustjoki
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Background Relatlimab plus nivolumab (anti–lymphocyte-activation gene 3 plus anti–programmed death 1 [anti–LAG-3+anti–PD-1]) has been approved by the FDA as a first-line therapy for stage III/IV melanoma, but its detailed effect on the immune
Externí odkaz:
https://doaj.org/article/45e8a21ae8814471ba60e41684de20f1
Autor:
Heikki Kuusanmäki, Sari Kytölä, Ida Vänttinen, Tanja Ruokoranta, Amanda Ranta, Jani Huuhtanen, Minna Suvela, Alun Parsons, Annasofia Holopainen, Anu Partanen, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Imre Västrik, Olli Dufva, Sanna Siitonen, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Mika Kontro
Publikováno v:
Haematologica, Vol 108, Iss 7 (2022)
The BCL-2 inhibitor venetoclax has revolutionized the treatment of acute myeloid leukemia (AML) in patients not benefiting from intensive chemotherapy. Nevertheless, treatment failure remains a challenge, and predictive markers are needed, particular
Externí odkaz:
https://doaj.org/article/ed146fcdf2474b39baf1bf345a6c2b2c
Autor:
Helena Hohtari, Matti Kankainen, Shady Adnan-Awad, Bhagwan Yadav, Swapnil Potdar, Aleksandr Ianevski, Olli Dufva, Caroline Heckman, Veronika Sexl, Soili Kytölä, Satu Mustjoki, Kimmo Porkka
Publikováno v:
HemaSphere, Vol 6, Iss 3, p e701 (2022)
In adult patients, the treatment outcome of acute lymphoblastic leukemia (ALL) remains suboptimal. Here, we used an ex vivo drug testing platform and comprehensive molecular profiling to discover new drug candidates for B-ALL. We analyzed sensitivity
Externí odkaz:
https://doaj.org/article/8ef93768f7754e64a0bfcedd49b3938c
Autor:
Heikki Kuusanmäki, Aino-Maija Leppä, Petri Pölönen, Mika Kontro, Olli Dufva, Debashish Deb, Bhagwan Yadav, Oscar Brück, Ashwini Kumar, Hele Everaus, Bjørn T. Gjertsen, Merja Heinäniemi, Kimmo Porkka, Satu Mustjoki, Caroline A. Heckman
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/9d9ce60433f4483e96edb2bc4fcd137d
Autor:
Olli Dufva, Matti Kankainen, Tiina Kelkka, Nodoka Sekiguchi, Shady Adnan Awad, Samuli Eldfors, Bhagwan Yadav, Heikki Kuusanmäki, Disha Malani, Emma I Andersson, Paavo Pietarinen, Leena Saikko, Panu E. Kovanen, Teija Ojala, Dean A. Lee, Thomas P. Loughran, Hideyuki Nakazawa, Junji Suzumiya, Ritsuro Suzuki, Young Hyeh Ko, Won Seog Kim, Shih-Sung Chuang, Tero Aittokallio, Wing C. Chan, Koichi Ohshima, Fumihiro Ishida, Satu Mustjoki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Aggressive natural killer-cell leukemia (ANKL) has few targeted therapies. Here ANKL patients are reported to harbor STAT3, RAS-MAPK pathway, DDX3X and epigenetic modifier mutations; and drug sensitivity profiling uncovers the importance of the JAK-S
Externí odkaz:
https://doaj.org/article/a90516e221ea4f0c9791e1e130cc3ead
Autor:
Zoltán Wiener, Jenny Högström, Ville Hyvönen, Arja M. Band, Pauliina Kallio, Tanja Holopainen, Olli Dufva, Caj Haglund, Olli Kruuna, Guillermo Oliver, Yinon Ben-Neriah, Kari Alitalo
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1943-1956 (2014)
Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of these cells. We show here that a subpopulation of Prox1-transcription-factor-expressing cells have stem cell activity in inte
Externí odkaz:
https://doaj.org/article/8235eee890f041a6b1f8671f4eebed38
Autor:
Kimmo Porkka, Olli Kallioniemi, Caroline A. Heckman, Krister Wennerberg, Tero Aittokallio, Satu Mustjoki, Bjorn Tore Gjertsen, Maija Wolf, Minna Lehto, Riikka Räty, Janna Saarela, Katja Kivinen, Imre Västrik, Alun Parsons, Laura Turunen, Jani Saarela, Swapnil Potdar, Samuli Eldfors, Matti Kankainen, Olli Dufva, Heikki Kuusanmäki, Monica Hellesøy, Bhagwan Yadav, Mika Kontro, Oscar Brück, Ashwini Kumar, Disha Malani
We generated ex vivo drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision medicine tumor board (FPMTB) integrated clinical, molecular, and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336d0fdf55697653756deb0b188488b8
https://doi.org/10.1158/2159-8290.c.6549394.v1
https://doi.org/10.1158/2159-8290.c.6549394.v1
