Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Olli Carpén"'
Autor:
Jonas N. Kantonen, Suvi Kuivanen, Teemu Smura, Henri Puttonen, Eliisa Kekäläinen, Antti Sajantila, Liisa Myllykangas, Anu Kantele, Olli Vapalahti, Mikko I. Mäyränpää, Olli Carpén
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 8, Pp 1735-1737 (2024)
We assessed the distribution of SARS-CoV-2 at autopsy in 22 deceased persons with confirmed COVID-19. SARS-CoV-2 was found by PCR (2/22, 9.1%) and by culture (1/22, 4.5%) in skull sawdust, suggesting that live virus is present in tissues postmortem,
Externí odkaz:
https://doaj.org/article/51d3682f92744db0944d80a414841882
Autor:
Panu Aaltonen, Harri Mustonen, Pauli Puolakkainen, Caj Haglund, Katriina Peltola, Olli Carpén, Riitta Lassila, Hanna Seppänen
Publikováno v:
Cancer Medicine, Vol 13, Iss 14, Pp n/a-n/a (2024)
Abstract Introduction Pancreatic cancer (PC) is associated with a high risk of venous thromboembolic events (VTEs). We investigated the incidence of VTE before and after the diagnosis of PC and its association with overall survival. Methods We identi
Externí odkaz:
https://doaj.org/article/44a6135fe87e44a18cd6aa59ae4b7ab2
Autor:
Heidi Rausio, Alejandra Cervera, Vanina D. Heuser, Gun West, Jaana Oikkonen, Elena Pianfetti, Marta Lovino, Elisa Ficarra, Pekka Taimen, Johanna Hynninen, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpén, Kaisa Huhtinen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 51, Iss , Pp 100987- (2024)
Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified fr
Externí odkaz:
https://doaj.org/article/2d652944943a4b03bb95ad24b38668fe
Autor:
Miika Koskinen, Jani K. Salmi, Anu Loukola, Mika J. Mäkelä, Juha Sinisalo, Olli Carpén, Risto Renkonen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The populational heterogeneity of a disease, in part due to comorbidity, poses several complexities. Individual comorbidity profiles, on the other hand, contain useful information to refine phenotyping, prognostication, and risk assessment,
Externí odkaz:
https://doaj.org/article/03d4ff6811f241fa9a2ec1f1176de9d8
Autor:
Samu N. Kurki, Jonas Kantonen, Karri Kaivola, Laura Hokkanen, Mikko I. Mäyränpää, Henri Puttonen, FinnGen, Juha Martola, Minna Pöyhönen, Mia Kero, Jarno Tuimala, Olli Carpén, Anu Kantele, Olli Vapalahti, Marjaana Tiainen, Pentti J. Tienari, Kai Kaila, Johanna Hästbacka, Liisa Myllykangas
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract Apolipoprotein E ε4 allele (APOE4) has been shown to associate with increased susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic studies, but information on the role of APOE4 on the underlying pathology a
Externí odkaz:
https://doaj.org/article/2044334279664a359db8d3a20c8d5fbc
Autor:
Minja Pehrsson, Hanna Heikkinen, Ulla Wartiovaara-Kautto, Sampo Mäntylahti, Pia Bäckström, Mariann I. Lassenius, Kristiina Uusi-Rauva, Olli Carpén, Kaisa Elomaa
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 33, Iss , Pp 100911- (2022)
Background: Autosomal recessive Gaucher disease (GD) is likely underdiagnosed in many countries. Because the number of diagnosed GD patients in Finland is relatively low, and the true prevalence is currently not known, it was hypothesized that undiag
Externí odkaz:
https://doaj.org/article/b89df55e164e428891087e026837972c
Autor:
Elina A. Pietilä, Jordi Gonzalez-Molina, Lidia Moyano-Galceran, Sanaz Jamalzadeh, Kaiyang Zhang, Laura Lehtinen, S. Pauliina Turunen, Tomás A. Martins, Okan Gultekin, Tarja Lamminen, Katja Kaipio, Ulrika Joneborg, Johanna Hynninen, Sakari Hietanen, Seija Grénman, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpén, Joseph W. Carlson, Kaisa Lehti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Platinum chemotherapy is standard of care in ovarian cancers but treatment resistance commonly develops. Here, the authors show that the extracellular microenvironment is modulated following chemotherapy and the changes in matrix proteins and stiffne
Externí odkaz:
https://doaj.org/article/67c04582b2c44334b40a53907f9099c4
Autor:
Pia Roering, Arafat Siddiqui, Vanina D. Heuser, Swapnil Potdar, Piia Mikkonen, Jaana Oikkonen, Yilin Li, Sanna Pikkusaari, Krister Wennerberg, Johanna Hynninen, Seija Grenman, Kaisa Huhtinen, Annika Auranen, Olli Carpén, Katja Kaipio
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectiveA major challenge in the treatment of platinum-resistant high-grade serous ovarian cancer (HGSOC) is lack of effective therapies. Much of ongoing research on drug candidates relies on HGSOC cell lines that are poorly documented. The goal of
Externí odkaz:
https://doaj.org/article/682cdd5529f243d1abfe1e21b24f7510
Autor:
Joonas Jukonen, Lidia Moyano-Galceran, Katrin Höpfner, Elina A. Pietilä, Laura Lehtinen, Kaisa Huhtinen, Erika Gucciardo, Johanna Hynninen, Sakari Hietanen, Seija Grénman, Päivi M. Ojala, Olli Carpén, Kaisa Lehti
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Erythropoietin producing hepatocellular (Eph) receptors and their membrane-bound ligands ephrins are variably expressed in epithelial cancers, with context-dependent implications to both tumor-promoting and -suppressive processes in ways tha
Externí odkaz:
https://doaj.org/article/ecaf312fb199488291cd2a4acc2a122b
Autor:
Vanina D. Heuser, Aida Kiviniemi, Laura Lehtinen, Sune Munthe, Bjarne Winther Kristensen, Jussi P. Posti, Jussi O. T. Sipilä, Ville Vuorinen, Olli Carpén, Maria Gardberg
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background The prognosis of glioblastoma remains poor, related to its diffuse spread within the brain. There is an ongoing search for molecular regulators of this particularly invasive behavior. One approach is to look for actin regulating p
Externí odkaz:
https://doaj.org/article/98cfb8db406b442cacda4982cde9b588