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Expression and Localization of Estrogen Receptor-β in Murine and Human Bone

Autor: Lars-Gunnar Kindblom, Claes Ohlsson, Olle Vidal

Publikováno v: Journal of Bone and Mineral Research. 14:923-929

Estrogens have profound effects on bone metabolism. Cellular responses to estrogens are mediated by estrogen receptors (ERs) which belong to the nuclear receptor superfamily. Two estrogen receptors, ERalpha and ERbeta, have been cloned. Previously ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927e218ddcd6c029c9b0c43029fc1317
https://doi.org/10.1359/jbmr.1999.14.6.923

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Regulation of Osteoprotegerin mRNA Levels by Prostaglandin E2in Human Bone Marrow Stroma Cells

Autor: Claes Ohlsson, Sverker Ljunghall, Olle Vidal, Helena Brändström, Kenneth B. Jonsson, Östen Ljunggren

Publikováno v: Biochemical and Biophysical Research Communications. 247:338-341

The recently cloned osteoclastogenesis inhibitory factor, or osteoprotegerin (OPG), has been shown to be a potent inhibitor of osteoclast formation. The inhibition is believed to be mediated through specific binding of OPG to a cell surface ligand on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c7cffa5e85722a3a8db65447d5a2f7
https://doi.org/10.1006/bbrc.1998.8783

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Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss

Autor: Karin Hollberg, Olle Vidal, Jan-Åke Gustafsson, Sara H Windahl, Claes Ohlsson, Göran Andersson

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 16(8)

Recently, it has been shown that inactivation of estrogen receptor beta (ER-beta) by gene targeting results in increased cortical bone formation in adolescent female mice. To study the possible involvement of ER-beta in the regulation of the mature s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7733a3533121214ca30fca49362efcd3
https://pubmed.ncbi.nlm.nih.gov/11499861

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Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

Autor: Claes Ohlsson, Marie K. Lindberg, Karin Hollberg, Olle Vidal, Göran Andersson, Dennis B. Lubahn, David J. Baylink, Subburaman Mohan, Jan-Ake Gustafsson

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 97(10)

Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e34b6c4fd6896f960289a2bf629af73
https://pubmed.ncbi.nlm.nih.gov/10805804

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Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice

Autor: Olle Vidal, Göran Andersson, Claes Ohlsson, Jan-Ake Gustafsson, Sara H Windahl

Publikováno v: The Journal of clinical investigation. 104(7)

Ovariectomy in young, growing rodents results in decreased trabecular bone mineral density (BMD) and increased radial growth of the cortical bone. Both of these effects are reversed by treatment with estrogen. The aim of the present study was to dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e31a0b46357ca14725d38918d2d0bb7
https://pubmed.ncbi.nlm.nih.gov/10510330

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Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

Autor: Kristina Blad, Olle Vidal, John-Olov Jansson, Derek LeRoith, Ville Wallenius, Claes Ohlsson, Stanko Skrtic, Jan Törnell, Jun-Li Liu, Olle Isaksson, Klara Sjögren

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 96(12)

The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a829539af63e757b5b834f48b0c103f6
https://pubmed.ncbi.nlm.nih.gov/10359843

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Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells

Autor: Olle Vidal, Claes Ohlsson, Bengt I. Eriksson, Östen Ljunggren, Klara Sjögren

Publikováno v: Biochemical and biophysical research communications. 248(3)

Osteoprotegerin (OPG) is a soluble receptor for the Osteoprotegerin-Ligand (OPGL) which is expressed on osteoblasts and mediates the signal for osteoclast differentiation. In the present study we demonstrate that OPG mRNA levels in MG-63 cells are in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d6501c3b81cc745f1e9d64c1272e08
https://pubmed.ncbi.nlm.nih.gov/9703989

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Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells

Autor: Sverker Ljunghall, Olle Vidal, Helena Brändström, Claes Ohlsson, Kenneth B. Jonsson, Östen Ljunggren

Publikováno v: Biochemical and biophysical research communications. 248(3)

Osteoprotegerin (OPG) is a recently cloned soluble member of the tumor necrosis factor receptor family. OPG has been shown to inhibit osteoclast recruitment by binding to OPG-ligand, an osteoclast differentiating factor on osteoblastic stromal cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c32e104adb36d9362bfc11cd363b87
https://pubmed.ncbi.nlm.nih.gov/9703945

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