Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Olle R. Lindberg"'
Autor:
Dalel Saidi, Mathilde Cheray, Ahmed M. Osman, Vassilis Stratoulias, Olle R. Lindberg, Xianli Shen, Klas Blomgren, Bertrand Joseph
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
High-grade gliomas are malignant aggressive primary brain tumors with limited therapeutic options, and dismal prognosis for patients. Microglia, the resident immune cells of the brain, are recruited and reprogrammed into tumor-supporting cells by gli
Externí odkaz:
https://doaj.org/article/04be59e649ab4c00ad14975e223f1513
Autor:
Anders I. Persson, William A. Weiss, Valerie M. Weaver, Dandan Sun, Daniele Arosio, Joanna J. Phillips, Mitchel S. Berger, Sergey Magnitsky, Jason A. Burdick, Janna K. Mouw, Olle R. Lindberg, Supna Saxena, Jacqueline R. Trzeciak, Edith Yuan, Trenten Fenster, David A. Quigley, Christin Schmidt, Jon N. Lakins, Aurora Idilli, Wen Zhu, Aaron Frantz, Yekaterina A. Miroshnikova, Hanna Sabelström, Shirin Ilkhanizadeh
Fig. S2. Interstitial fluid pressure (IFP) pressure sensors do not increase reactive gliosis or microglia activation during tumor progression. (A, B) GFAP+ reactive astrocytes (DAB; brown) and (C, D) Iba1+ tumor-associated macrophages (DAB; brown) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469f715d35ef062041e132ffa4999561
https://doi.org/10.1158/1541-7786.22513050.v1
https://doi.org/10.1158/1541-7786.22513050.v1
Autor:
Joanna J. Phillips, C. David James, Mausam Kalita, Anupam Kumar, Spencer J. Brown, Vy M. Tran, Katharine Y. Chen, Olle R. Lindberg, Anna Wade, Yuki Ohkawa
Glypican-1 and Syndecan-1 are identified as heparan sulfate proteoglycans expressed on GBM43.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e007ea27a3ea6b4c95f755c43a6274
https://doi.org/10.1158/1541-7786.22526117.v1
https://doi.org/10.1158/1541-7786.22526117.v1
Autor:
Anders I. Persson, William A. Weiss, Valerie M. Weaver, Dandan Sun, Daniele Arosio, Joanna J. Phillips, Mitchel S. Berger, Sergey Magnitsky, Jason A. Burdick, Janna K. Mouw, Olle R. Lindberg, Supna Saxena, Jacqueline R. Trzeciak, Edith Yuan, Trenten Fenster, David A. Quigley, Christin Schmidt, Jon N. Lakins, Aurora Idilli, Wen Zhu, Aaron Frantz, Yekaterina A. Miroshnikova, Hanna Sabelström, Shirin Ilkhanizadeh
Interstitial fluid pressure (IFP) presents a barrier to drug uptake in solid tumors, including the aggressive primary brain tumor glioblastoma (GBM). It remains unclear how fluid dynamics impacts tumor progression and can be targeted therapeutically.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0abd1a8d41cfcedb773f67cfcb00588
https://doi.org/10.1158/1541-7786.c.6540420.v1
https://doi.org/10.1158/1541-7786.c.6540420.v1
Autor:
Joanna J. Phillips, William A. Weiss, Monika E. Hegi, Albert Lai, William H. Yong, Theodore P. Nicolaides, C. David James, Joseph T.C. Shieh, Mitchel S. Berger, Andrew W. Bollen, Michael Prados, Linda M. Liau, Timothy F. Cloughesy, Erin F. Simonds, Kan V. Lu, Henry Gong, Anupam Kumar, Katharine Y. Chen, Jane R. Engler, Olle R. Lindberg, Andrew McKinney
Supplementary Figure S1 shows increased invasion is specific to EGFR inhibition, increased ALDH1A1 expression is not specific to erlotinib but also occurs with AG1478 and lapatinib, and EGFR inhibition increases expression of several genes implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00141c8ad56ed4fbd4e04e650a02b942
https://doi.org/10.1158/1535-7163.22506199
https://doi.org/10.1158/1535-7163.22506199
Autor:
Joanna J. Phillips, William A. Weiss, Monika E. Hegi, Albert Lai, William H. Yong, Theodore P. Nicolaides, C. David James, Joseph T.C. Shieh, Mitchel S. Berger, Andrew W. Bollen, Michael Prados, Linda M. Liau, Timothy F. Cloughesy, Erin F. Simonds, Kan V. Lu, Henry Gong, Anupam Kumar, Katharine Y. Chen, Jane R. Engler, Olle R. Lindberg, Andrew McKinney
Amplification of the epidermal growth factor receptor gene (EGFR) represents one of the most commonly observed genetic lesions in glioblastoma (GBM); however, therapies targeting this signaling pathway have failed clinically. Here, using human tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab7e13d5ba0dbfc1f50b929a8ae3a3d
https://doi.org/10.1158/1535-7163.c.6538321.v1
https://doi.org/10.1158/1535-7163.c.6538321.v1
Autor:
Joanna J. Phillips, C. David James, Mausam Kalita, Anupam Kumar, Spencer J. Brown, Vy M. Tran, Katharine Y. Chen, Olle R. Lindberg, Anna Wade, Yuki Ohkawa
Signaling from multiple receptor tyrosine kinases (RTK) contributes to therapeutic resistance in glioblastoma (GBM). Heparan sulfate (HS), present on cell surfaces and in the extracellular matrix, regulates cell signaling via several mechanisms. To i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d98ec6f6bcea13752583634f3567fa
https://doi.org/10.1158/1541-7786.c.6545015.v1
https://doi.org/10.1158/1541-7786.c.6545015.v1
Autor:
Anders I. Persson, William A. Weiss, Valerie M. Weaver, Dandan Sun, Daniele Arosio, Joanna J. Phillips, Mitchel S. Berger, Sergey Magnitsky, Jason A. Burdick, Janna K. Mouw, Olle R. Lindberg, Supna Saxena, Jacqueline R. Trzeciak, Edith Yuan, Trenten Fenster, David A. Quigley, Christin Schmidt, Jon N. Lakins, Aurora Idilli, Wen Zhu, Aaron Frantz, Yekaterina A. Miroshnikova, Hanna Sabelström, Shirin Ilkhanizadeh
Compression-induced changes in the transcriptional GBM phenotype. Differentially expressed genes in tumorspheres derived from human GBMs (GBM5, GBM14, GBM34, and GBM43) when comparing compression to other conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1789986a60b5f0ae643d577602928d1c
https://doi.org/10.1158/1541-7786.22513029.v1
https://doi.org/10.1158/1541-7786.22513029.v1
Autor:
Joanna J. Phillips, Mausam Kalita, Vy M. Tran, Spencer Brown, C. David James, Katharine Chen, Anupam Kumar, Olle R. Lindberg, Yuki Ohkawa, Anna Wade
Publikováno v:
Molecular Cancer Research. 19:150-161
Signaling from multiple receptor tyrosine kinases (RTK) contributes to therapeutic resistance in glioblastoma (GBM). Heparan sulfate (HS), present on cell surfaces and in the extracellular matrix, regulates cell signaling via several mechanisms. To i
Autor:
Katharine Chen, Vy M. Tran, Olle R. Lindberg, Anders Persson, Jane R. Engler, Andrew McKinney, Anna Wade, Joanna J. Phillips
Publikováno v:
Molecular cancer research : MCR, vol 15, iss 11
Glioblastoma (GBM) is the most common primary malignant brain tumor of adults and confers a poor prognosis due, in part, to diffuse invasion of tumor cells. Heparan sulfate (HS) glycosaminoglycans, present on the cell surface and in the extracellular