Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Olle Larsson"'
Autor:
Bhawana George, Suraj Konnath George, Wenyu Shi, Abedul Haque, Ping Shi, Ghazaleh Eskandari, Magnus Axelson, Olle Larsson, Ahmed O. Kaseb, Hesham M. Amin
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a0382356caff4098bd02e6b4faad547e
Autor:
Yi Chen, Asle C. Hesla, Yingbo Lin, Mehran Ghaderi, Mingzhi Liu, Chen Yang, Yifan Zhang, Panagiotis Tsagkozis, Olle Larsson, Felix Haglund
Publikováno v:
Molecular Oncology, Vol 14, Iss 5, Pp 1101-1117 (2020)
Ewing sarcomas (ESs) are aggressive sarcomas driven by EWS fusion genes. We sought to investigate whether whole‐transcriptome sequencing (RNA‐seq) could be used to detect patterns associated with chemotherapy response or tumor progression after f
Externí odkaz:
https://doaj.org/article/fa8a9c3d63ef4c5c8c8c7eb770313be1
Autor:
Bhawana George, Suraj Konnath George, Wenyu Shi, Abedul Haque, Ping Shi, Ghazaleh Eskandari, Magnus Axelson, Olle Larsson, Ahmed O. Kaseb, Hesham M. Amin
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-15 (2019)
Abstract Background Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK+) T cell lymphoma is an aggressive neoplasm. NPM-ALK, an oncogenic tyrosine kinase, plays a critical role in this lymphoma. Recently, selective ALK inhibitors have emerg
Externí odkaz:
https://doaj.org/article/b70f27fbe48346cdb640e2c586f4ed3f
Autor:
Chen Yang, Yifan Zhang, Yi Chen, Franziska Ragaller, Mingzhi Liu, Sara Corvigno, Hanna Dahlstrand, Joseph Carlson, Zihua Chen, Anders Näsman, Ahmed Waraky, Yingbo Lin, Olle Larsson, Felix Haglund
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236291 (2020)
Nuclear IGF1R has been linked to poor outcome in cancer. We recently showed that nuclear IGF1R phosphorylates PCNA and increases DNA damage tolerance. In this paper we aimed to describe this mechanism in cancer tissue as well as in cancer cell lines.
Externí odkaz:
https://doaj.org/article/4387bfc1e8ee490c9843833fc942d6ae
Autor:
Chang Yin, Temesgen Fufa, Gayathri Chandrasekar, Madhu Aeluri, Verina Zaky, Shaimaa Abdelhady, Antonio B. Rodríguez, Johan Jakobsson, Farzaneh Shahin Varnoosfaderani, Jayashri Mahalingam, Jianping Liu, Olle Larsson, Outi Hovatta, Frank Gaunitz, Anita Göndör, Michael Andäng, Satish S. Kitambi
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Stem cells display a fundamentally different mechanism of proliferation control when compared to somatic cells. Uncovering these mechanisms would maximize the impact in drug discovery with a higher translational applicability. The unbiased approach u
Externí odkaz:
https://doaj.org/article/92b21c9fe7724cbb9f73f8be6d34d7ce
Autor:
Jan Åhlén, Ulla Enberg, Catharina Larsson, Olle Larsson, Tony Frisk, Otte Brosjö, Anette von Rosen, Martin Bäckdahl
Publikováno v:
Sarcoma, Vol 5, Iss 3, Pp 143-149 (2001)
Purpose: Extracellular matrix metalloproteinase inducer (EMMPRIN) has been shown to stimulate fibroblasts to production of matrix metalloproteinases (MMPs). MMPs comprise a family of proteolytic enzymes implicated in the degradation of extracellular
Externí odkaz:
https://doaj.org/article/aeb843ed75944b01be07e5e002b01797
Publikováno v:
Sarcoma, Vol 3, Iss 1, Pp 25-32 (1999)
Purpose. Recently we showed that the 68-kDa fusion protein derived from the EWS/FLI1 hybrid gene can be specifically detected by Western blotting using a polyclonal antibody to the C-terminal of FLI1 on biopsy material from Ewing's sarcoma. The ai
Externí odkaz:
https://doaj.org/article/d2b80917bfd64ffda833d30c4f173eb3
Autor:
Jamileh Hashemi, Claire Worrall, Daiana Vasilcanu, Mårten Fryknäs, Luqman Sulaiman, Mohsen Karimi, Wen-Hui Weng, Weng-Onn Lui, Christina Rudduck, Magnus Axelson, Helena Jernberg-Wiklund, Leonard Girnita, Olle Larsson, Catharina Larsson
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e14757 (2011)
BACKGROUND: Picropodophyllin (PPP) is a promising novel anti-neoplastic agent that efficiently kills tumor cells in vitro and causes tumor regression and increased survival in vivo. We have previously reported that PPP treatment induced moderate tole
Externí odkaz:
https://doaj.org/article/ec708690f09a4924ab882776863652fb
Publikováno v:
PLoS ONE, Vol 2, Iss 4, p e340 (2007)
BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase
Externí odkaz:
https://doaj.org/article/7e2cb66205a345e9b25ab69887a6e31d
Autor:
Ilka Isfort, Ruth Berthold, Lorena Heinst, Eva Wardelmann, Olle Larsson, Marcel Trautmann, Wolfgang Hartmann
Publikováno v:
Molecular Cancer Research. 21:535-547
Synovial sarcoma, a rare malignant soft tissue tumor, is characterized by a specific chromosomal translocation t(X;18). The resulting chimeric SS18-SSX fusion protein drives synovial sarcoma pathogenesis by integrating into the BAF complex and dysreg