Connectivity mapping of glomerular proteins identifies dimethylaminoparthenolide as a new inhibitor of diabetic kidney disease

Autor: Julie Klein, Cécile Caubet, Mylène Camus, Manousos Makridakis, Colette Denis, Marion Gilet, Guylène Feuillet, Simon Rascalou, Eric Neau, Luc Garrigues, Olivier Thillaye du Boullay, Harald Mischak, Bernard Monsarrat, Odile Burlet-Schiltz, Antonia Vlahou, Jean Sébastien Saulnier-Blache, Jean-Loup Bascands, Joost P. Schanstra

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.14898. ⟨10.1038/s41598-020-71950-7⟩
Scientific Reports, 2020, 10 (1), pp.14898. ⟨10.1038/s41598-020-71950-7⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

International audience; Abstract While blocking the renin angiotensin aldosterone system (RAAS) has been the main therapeutic strategy to control diabetic kidney disease (DKD) for many years, 25–30% of diabetic patients still develop the disease. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ed44fa7306659132bfb73167665602c8
https://www.hal.inserm.fr/inserm-03268523

A non-symmetric sulfur-based O , C , O -chelating pincer ligand leading to chiral germylene and stannylene

Autor: Ionut-Tudor Moraru, Sonia Mallet-Ladeira, Olivier Thillaye du Boullay, David Madec, Noémi Deak, Gabriela Nemes

Publikováno v: Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, 2019, 48 (7), pp.2399-2406. ⟨10.1039/c8dt05116j⟩

New chiral heteroleptic germanium(ii) and tin(ii) metallylenes were obtained using 1-(para-tolylsulfinyl)-3-tosyl-5-tert-butyl-benzene as a non-symmetric O,C,O-chelating pincer ligand. Crystallographic analysis and DFT calculations indicate that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7437a1b92e914e0cfff0acb44b4852
https://hal.archives-ouvertes.fr/hal-02321975

Organo-Catalyzed Ring Opening Polymerization of a 1,4-Dioxane-2,5-dione Deriving from Glutamic Acid

Autor: Jean-Pierre Diehl, Didier Bourissou, Olivier Thillaye du Boullay, Blanca Martin-Vaca, Nathalie Saffon

Publikováno v: Biomacromolecules. 11:1921-1929

The (3S)-[(benzyloxycarbonyl)ethyl]-1,4-dioxan-2,5-dione (BED) was prepared in four steps starting from glutamic acid and bromoacetyl bromide. According to X-ray diffraction analysis, the pendant functional group is located in equatorial position and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d1ad3ce199dbbef819affd635ef1ec
https://doi.org/10.1021/bm100433c

Functionalized polyesters from organocatalyzed ROP of gluOCA, the O-carboxyanhydride derived from glutamic acid

Autor: Didier Bourissou, Colin Bonduelle, Blanca Martin-Vaca, Olivier Thillaye du Boullay

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2008, pp.1786-1788
HAL

Well-controlled poly(alpha-hydroxyacids) featuring pendant carboxylic acid groups were prepared under mild conditions via DMAP-catalyzed ROP of the O-carboxyanhydrides derived from glutamic and lactic acids.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c95314c05f464a831290301e9eda750
https://pubmed.ncbi.nlm.nih.gov/18379693

An activated equivalent of lactide toward organocatalytic ring-opening polymerization

Autor: † Blanca Martin-Vaca, Olivier Thillaye du Boullay, Didier Bourissou, Emmanuel Marchal, and Fernando P. Cossío

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2006, 128, pp.16442-16443

The alpha-lactone equivalent lacOCA exhibits remarkable reactivity compared with lactide in nucleophile-catalyzed ROP. PLAs of controlled molecular weights and narrow polydispersities are typically obtained under mild conditions using DMAP and variou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d72020b7aa9eeb69a002728dbcd9798
https://pubmed.ncbi.nlm.nih.gov/17177360