Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Olivier Sordet"'
Autor:
Mathéa Geraud, Agnese Cristini, Simona Salimbeni, Nicolas Bery, Virginie Jouffret, Marco Russo, Andrea Carla Ajello, Lara Fernandez Martinez, Jessica Marinello, Pierre Cordelier, Didier Trouche, Gilles Favre, Estelle Nicolas, Giovanni Capranico, Olivier Sordet
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114214- (2024)
Summary: TDP1 removes transcription-blocking topoisomerase I cleavage complexes (TOP1ccs), and its inactivating H493R mutation causes the neurodegenerative syndrome SCAN1. However, the molecular mechanism underlying the SCAN1 phenotype is unclear. He
Externí odkaz:
https://doaj.org/article/d37f0288c1ca4085bf68d93fbf8946d1
Autor:
Agnese Cristini, Michael Tellier, Flavia Constantinescu, Clelia Accalai, Laura Oana Albulescu, Robin Heiringhoff, Nicolas Bery, Olivier Sordet, Shona Murphy, Natalia Gromak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
RnaseH2 is mutated in severe neuro-inflammatory disorder Aicardi‐Goutières syndrome. Here the authors reveal that RNase H2 controls cellular R-loop homeostasis to promote transcription, genome integrity and prevent R-loop-associated inflammation.
Externí odkaz:
https://doaj.org/article/ce3b6dce4d124373af4074e75f08106c
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 2 (2020)
Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs aris
Externí odkaz:
https://doaj.org/article/6dcf53163fb941f6bd9c9f2fd1d788f5
Autor:
Agnese Cristini, Giulia Ricci, Sébastien Britton, Simona Salimbeni, Shar-yin Naomi Huang, Jessica Marinello, Patrick Calsou, Yves Pommier, Gilles Favre, Giovanni Capranico, Natalia Gromak, Olivier Sordet
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3167-3181.e6 (2019)
Summary: Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding of how transcription produces DNA double-strand breaks (DSBs) is limited. Transcription-blocking topoisomer
Externí odkaz:
https://doaj.org/article/1021112fc04b439383b6092523d8e7f5
Autor:
Jessica Marinello, Stefania Bertoncini, Iris Aloisi, Agnese Cristini, Guidantonio Malagoli Tagliazucchi, Mattia Forcato, Olivier Sordet, Giovanni Capranico
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147053 (2016)
Topoisomerase I-DNA-cleavage complexes (Top1cc) stabilized by camptothecin (CPT) have specific effects at transcriptional levels. We recently reported that Top1cc increase antisense transcript (aRNAs) levels at divergent CpG-island promoters and, tra
Externí odkaz:
https://doaj.org/article/56b6b2a2bceb4d119514f74157abb240
Autor:
Yves Pommier, Mirit I. Aladjem, Angela Fan, Melvenia M. Martin, Olivier Sordet, Gabriel S. Eichler, Elisabetta Leo, Chiara Conti
Supplementary Figures 1-4 from Inhibition of Histone Deacetylase in Cancer Cells Slows Down Replication Forks, Activates Dormant Origins, and Induces DNA Damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8964ab492144915bfead6d9eb16e05
https://doi.org/10.1158/0008-5472.22381871.v1
https://doi.org/10.1158/0008-5472.22381871.v1
Autor:
Yves Pommier, Mirit I. Aladjem, Angela Fan, Melvenia M. Martin, Olivier Sordet, Gabriel S. Eichler, Elisabetta Leo, Chiara Conti
Protein acetylation is a reversible process regulated by histone deacetylases (HDAC) that is often altered in human cancers. Suberoylanilide hydroxamic acid (SAHA) is the first HDAC inhibitor to be approved for clinical use as an anticancer agent. Gi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::001a0fded4a51990b86a7b5b6cf386a0
https://doi.org/10.1158/0008-5472.c.6500006.v1
https://doi.org/10.1158/0008-5472.c.6500006.v1
Publikováno v:
International review of cell and molecular biology. 364
Transcription is an essential cellular process but also a major threat to genome integrity. Transcription-associated DNA breaks are particularly detrimental as their defective repair can induce gene mutations and oncogenic chromosomal translocations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f605fe4c026788e231db018ded1c7b1b
https://pubmed.ncbi.nlm.nih.gov/34507784
https://pubmed.ncbi.nlm.nih.gov/34507784
Autor:
Marco Russo, Alessio De Magis, Rita Morigi, Olivier Sordet, Jessica Marinello, Stefano G. Manzo, Giovanni Capranico
Publikováno v:
Proceedings of the National Academy of Sciences. 116:816-825
G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic nuclear processes and trigger DNA damage, genome instability, and cell killing. By different technical approaches, we here establish that specific G4 ligands sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72750f5d4e9e4d55df9120b87c7a582d
https://doi.org/10.1073/pnas.1810409116
https://doi.org/10.1073/pnas.1810409116
Publikováno v:
Chromatin and Genomic Instability in Cancer ISBN: 9780323855617
Transcription is an essential cellular process but also a major threat to genome integrity. Transcription-associated DNA breaks are particularly detrimental as their defective repair can induce gene mutations and oncogenic chromosomal translocations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::307ea4bb1f2ff2201db98d8aaa6e3407
https://doi.org/10.1016/bs.ircmb.2021.05.001
https://doi.org/10.1016/bs.ircmb.2021.05.001