Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Olivier Rogel"'
Autor:
Stefanie Flohr, Simon Rüdisser, Anna Vulpetti, Andrea De Erkenez, Stefan Steinbacher, Olivier Rogel, Laurence Kieffer, Solene Dussauge, Louis Yang, Frederic Cumin, Karen Anderson, Aengus Mac Sweeney, Edwige Lorthiois, Nils Ostermann, Ronald Newton, Viral Kansara, Sha-Mei Liao, Ulrich Hommel, Constanze Hartwieg, Upendra A. Argikar, Stefan Andreas Randl, Laura R. La Bonte, Omar Delgado, Kamal Fettis, Jürgen Maibaum, Bruce D Jaffee
Publikováno v:
Journal of Medicinal Chemistry. 60:5717-5735
The highly specific S1 serine protease factor D (FD) plays a central role in the amplification of the complement alternative pathway (AP) of the innate immune system. Genetic associations in humans have implicated AP activation in age-related macular
Autor:
Henrik Möbitz, Rainer Machauer, Olivier Rogel, Heinrich Rueeger, Rainer Martin Lueoend, Matthias Staufenbiel, Sandrine Desrayaud, Jean-Michel Rondeau, Laura H. Jacobson, Ulf Neumann
Publikováno v:
Journal of Medicinal Chemistry. 55:3364-3386
Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the s
Autor:
Olivier Rogel, Tommasi Ruben A, J. R. Doughty, James Fang, Robert Goldstein, Raviraj Kulathila, Clayton Springer, Kirk Clark, Vishwas Ganu, Sven Weiler, Lijuan Zhu, Mark Chambers, Marc Walker, Stacey LaVoie, Jonathan E. Grob, Leslie Wighton Mcquire, Michael Shultz, Ronald L. Goldberg, Richard Melton, William Macchia, Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6440-6445
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would provide a disease modifying therapy for the treatment of arthritis, a
Publikováno v:
Tetrahedron Letters. 42:6061-6064
An alternative synthesis and the thermal atropisomerism of a fully functionalized DEFG ring system of teicoplanin are described.
Autor:
Dale L. Boger, Jian-Hui Weng, Seong Heon Kim, Olivier Rogel, Yoshiki Mori, J. Jeffrey McAtee, Steven L. Castle
Publikováno v:
Journal of the American Chemical Society. 123:1862-1871
Full details of studies leading to the total synthesis of the teicoplanin aglycon are provided. Key elements of the first generation approach (26 steps from constituent amino acids, 1% overall) include the coupling of an EFG tripeptide precursor to t
Autor:
Qing Jin, Susumu Miyazaki, J. Jeffrey McAtee, and Harald Strittmatter, Jian-Hui Weng, Yoshiki Mori, Seong Heon Kim, Steven L. Castle, Dale L. Boger, Olivier Rogel
Publikováno v:
Journal of the American Chemical Society. 122:10047-10055
The degradation of teicoplanin to a series of key aglycon derivatives, including those containing a cleaved FG ring system, and a study of their thermal atropisomerism are detailed. In all cases, selective equilibration of the DE ring system was obse
Autor:
Olivier Rogel, Stephen Hanessian
Publikováno v:
ChemInform. 30
The phostone analog of phosphoramidon, an inhibitor of endothelin converting enzyme, was synthesized from l-rhamnose. Coupling of the cyclic phosphonic acid with the dipeptide H-Leu-Trp-OMe gave, after deprotection and purification by reverse-phase H
Autor:
Stephen Hanessian, Olivier Rogel
Publikováno v:
ChemInform. 31
Analogues of l-fucose, N-acetyl-d-glucosamine, N-acetyl-d-mannosamine, and N-acetyl neuraminic acid in which the anomeric carbon atom was replaced by a phosphonyl group (phostones or cyclic phosphonates) were synthesized by stereocontrolled methods r
Publikováno v:
ChemInform. 33
An alternative synthesis and the thermal atropisomerism of a fully functionalized DEFG ring system of teicoplanin are described.
Publikováno v:
The Journal of organic chemistry. 67(10)
A synthesis of an antagonist of E-selectin previously reported by a group at Novartis Pharma in Basel is described. An important feature involves the formation of an ether linkage based on a Rh(II)-catalyzed reaction. Stereocontrolled glycosylations