Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Olivier Lorthioir"'
Autor:
Neil Patrick Grimster, Lakshmaiah Gingipalli, Amber Balazs, Bernard Barlaam, Scott Boiko, Scott Boyd, Hannah Dry, Frederick W. Goldberg, Tim Ikeda, Tony Johnson, Sameer Kawatkar, Paul Kemmitt, Scott Lamont, Olivier Lorthioir, Adelphe Mfuh, Joe Patel, Andy Pike, Jon Read, Romulo Romero, Ujjal Sarkar, Li Sha, Iain Simpson, Kun Song, Qibin Su, Haixia Wang, David Watson, Allan Wu, Troy E. Zehnder, XiaoLan Zheng, Shaolu Li, Zhiqiang Dong, Dejian Yang, Yanwei Song, Peng Wang, Xuemei Liu, James E. Dowling, Scott D. Edmondson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7db10a4172a7f6e477f5fdb84a232a7f
https://doi.org/10.2139/ssrn.4308038
https://doi.org/10.2139/ssrn.4308038
Autor:
Dušan Petrović, James S. Scott, Michael S. Bodnarchuk, Olivier Lorthioir, Scott Boyd, George M. Hughes, Jordan Lane, Allan Wu, David Hargreaves, James Robinson, Jens Sadowski
Publikováno v:
Journal of chemical information and modeling. 62(16)
ROS1 rearrangements account for 1-2% of non-small cell lung cancer patients, yet there are no specifically designed, selective ROS1 therapies in the clinic. Previous knowledge of potent ROS1 inhibitors with selectivity over TrkA, a selected antitarge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c3f840f353a4182bae8a31782f88c5
https://pubmed.ncbi.nlm.nih.gov/35920716
https://pubmed.ncbi.nlm.nih.gov/35920716
Autor:
Darren Cross, Matthew J. Martin, Carine M. Guérot, Nicolas Floc'h, Clare Gregson, Jonathan P. Orme, Michal Bista, Lin Xue, Xu Li, Amar Rahi, Xiliang Zhao, Richard A. Ward, L. Evans, Gail L. Wrigley, Arash Mosallanejad, Tieguang Yao, Claire McWhirter, David J. Hargreaves, Nicola Colclough, Sue Bickerton, Darren Mckerrecher, Peter Barton, Yang Ye, Yi Liu, Marta Wylot, M. Raymond V. Finlay, Xiaoming Kang, Eva M. Lenz, Daniel O'Neill, Verity Talbot, Olivier Lorthioir, Paul D. Smith
Publikováno v:
Journal of medicinal chemistry. 64(18)
The epidermal growth factor receptor (EGFR) harboring activating mutations is a clinically validated target in non-small-cell lung cancer, and a number of inhibitors of the EGFR tyrosine kinase domain, including osimertinib, have been approved for cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58199c545ee296c2c44cec7db12bfba5
https://pubmed.ncbi.nlm.nih.gov/34491761
https://pubmed.ncbi.nlm.nih.gov/34491761
Publikováno v:
Tetrahedron Letters. 108:154129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f53674bd9e30c1165ccb6bf16f1d9c2
https://doi.org/10.1016/j.tetlet.2022.154129
https://doi.org/10.1016/j.tetlet.2022.154129
Autor:
Ali Ates, Valérie Verbois, Gwenael Dehon, Patrick Lo Brutto, Bénédicte Lallemand, Pierre Burssens, Jean Keyaerts, Michel Gillard, Celine Vermeiren, Francis Coloretti, Olivier Lorthioir
Publikováno v:
ChemMedChem. 13:795-802
Selective leads: In this study, we generated a new series of serotonin 5-HT7 receptor antagonists. Their synthesis, structure-activity relationships, and selectivity profiles are reported. This series includes 5-HT7 antagonists with unprecedented hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a262caf4c1727526c6247fefd414c041
https://doi.org/10.1002/cmdc.201800026
https://doi.org/10.1002/cmdc.201800026
Autor:
Olivier Lorthioir, Turner Paul, Katie Proctor, Thomas Corner, Sylvain Demanze, Ryan Greenwood, Stephen Stokes
Publikováno v:
Tetrahedron Letters. 84:153447
In this study we successfully transferred a useful photochemical reaction from the UV to the visible region of the spectrum. Use of a commercially available iridium complex facilitated triplet state intramolecular [2 + 2] photocycloaddition under irr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fba135933d42e7732c8c83b0e3ff027
https://doi.org/10.1016/j.tetlet.2021.153447
https://doi.org/10.1016/j.tetlet.2021.153447
Autor:
Olivier Lorthioir, Arash Mosallanejad
Publikováno v:
Tetrahedron Letters. 59:1708-1710
The versatility of the under-utilised (cyanomethylene)tributylphosphorane (CMBP, Tsunoda reagent) was demonstrated on two occasions in a drug discovery context. Firstly, the high reactivity of the phosphorane allowed the alkylation of a weakly acidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936ce579b101dea3ce7a3fd97cd438ca
https://doi.org/10.1016/j.tetlet.2018.03.045
https://doi.org/10.1016/j.tetlet.2018.03.045
Publikováno v:
Tetrahedron Letters. 61:152600
In this work we describe the preparation of novel fused, spirocyclic and chiral triazolopiperazines. We have developed a practical, rapid and robust synthetic route to these scaffolds that allows control of regio- and stereochemistry. This method uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d4ecaa8761dc332fa8d97e60c6d982f
https://doi.org/10.1016/j.tetlet.2020.152600
https://doi.org/10.1016/j.tetlet.2020.152600
Autor:
Huimin Wang, Tony Johnson, Sameer Kawatkar, Peng Wang, Lakshmaiah Gingipalli, Scott D. Edmondson, Jon Read, Scott Boyd, Timothy Ikeda, Andrew Pike, Qibin Su, Olivier Lorthioir, Lianghe Wang, Hannah Dry, Hannah Pollard, Barlaam Bernard Christophe, Haiyun Wang, Scott Boiko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127523
Hybridisation of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimisation of a novel pyrimidine-based series of potent and selective SYK inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64b2339e860fa1c384ebed0af403608
https://doi.org/10.1016/j.bmcl.2020.127523
https://doi.org/10.1016/j.bmcl.2020.127523
Autor:
Jean-Philippe Courade, Judith van Asperen, Olivier Lorthioir, Kyoko Koshibu, Helga Gerets, Javier Garcia-Ladona
Publikováno v:
Pharmacology. 96:240-247
Background/Aims: LRRK2 (leucine-rich repeat protein kinase 2) is one of the most commonly accepted genes associated with Parkinson's disease (PD). The overexpression of disease-associated mutations in LRRK2 is toxic to the cells, while reduction or e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5745b6158eb9ca033dab6828c59b27ea
https://doi.org/10.1159/000439136
https://doi.org/10.1159/000439136