Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Olivier Lemaitre"'
Autor:
Hélène Erasimus, Vanessa Kolnik, Frédéric Lacroix, Sukhvinder Sidhu, Stéphane D'Agostino, Olivier Lemaitre, Alexandre Rohaut, Isabelle Sanchez, Gilbert Thill, Michel Didier, Laurent Debussche, Christophe Marcireau
Publikováno v:
Cancer Research Communications. 3:780-792
The TGFβ signaling mediator SMAD4 is frequently mutated or deleted in colorectal and pancreatic cancers. SMAD4 acts as a tumor suppressor and its loss is associated with poorer patient outcomes. The purpose of this study was to find synthetic lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ca0883dc6bcb1d951f06b1e681aa502
https://doi.org/10.1158/2767-9764.crc-22-0301
https://doi.org/10.1158/2767-9764.crc-22-0301
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
RAB10 is crucial for the proliferation of the SMAD4-negative SW620 and HT29 cell lines. A, Design of the ND HA-tagged RAB10 allele (HA-RAB10 ND), with seven mutations, including one mutation in the PAM sequence. B, Plasmid used to transfect SW620-pCM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55204daa64254eda277feb69060a8f34
https://doi.org/10.1158/2767-9764.22761834.v1
https://doi.org/10.1158/2767-9764.22761834.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stephane D'Agostino, Sukhvinder S Sidhu, Frederic Lacroix, Vanessa Kolnik, Helene Erasimus
QCsummary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1424a8b7bdc1227bc959dca0697bee
https://doi.org/10.1158/2767-9764.22761804.v1
https://doi.org/10.1158/2767-9764.22761804.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stephane D'Agostino, Sukhvinder S Sidhu, Frederic Lacroix, Vanessa Kolnik, Helene Erasimus
Gene_scoreMageckComparison
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcdeeda43df0808765bdc1f66d43f47
https://doi.org/10.1158/2767-9764.22761795.v1
https://doi.org/10.1158/2767-9764.22761795.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
SMAD4-inducible restoration restores the TGFβ-induced growth inhibition of colorectal cancer cells in vivo.A,In vivo tumorigenicity assay. To assess the effects of SMAD4 restoration in SMAD4-deficient cell lines on tumorigenicity, parental cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da5e3547581eba7c2f8be17bd31a43b
https://doi.org/10.1158/2767-9764.22761849
https://doi.org/10.1158/2767-9764.22761849
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
SMAD4-inducible restoration restores the TGFβ-induced growth inhibition in colorectal and pancreatic cancer cells. A, Protein level of SMAD4 was assessed by Western blot analysis in SMAD4-reexpressing HT29 and SW620 cells. RKO, MDST8 and MIAPaCa-2 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a65bf407becec2e74785e180e6e6e8
https://doi.org/10.1158/2767-9764.22761852.v1
https://doi.org/10.1158/2767-9764.22761852.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
Identification of genes required for SMAD4-deficient cells viability via CRISPR/Cas9 viability screen. A, Identification of top candidates. Top 1,000 hits ranked by MAGeCK for each PD0 versus PD15 comparison were compared trough cell lines, as well t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d83a12bf2bc5ec1467089ffbbf5a65e
https://doi.org/10.1158/2767-9764.22761843
https://doi.org/10.1158/2767-9764.22761843
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stephane D'Agostino, Sukhvinder S Sidhu, Frederic Lacroix, Vanessa Kolnik, Helene Erasimus
sgRNAs against RAB10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2648f66549e325a47ef5df8b2b695221
https://doi.org/10.1158/2767-9764.22761789.v1
https://doi.org/10.1158/2767-9764.22761789.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
Construction and isolation of Cas9-expressing clones and workflow of our CRISPR screens. A, Levels of SMAD4 protein detected by the Sally Sue Simple Western system in the four cell lines HT29, SW620, DLD1, and MIAPaCa-2. B, Levels of Cas9 protein det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f53befc3feb1ad1c8a2e229b5ea7df
https://doi.org/10.1158/2767-9764.22761846
https://doi.org/10.1158/2767-9764.22761846
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
The TGFβ signaling mediator SMAD4 is frequently mutated or deleted in colorectal and pancreatic cancers. SMAD4 acts as a tumor suppressor and its loss is associated with poorer patient outcomes. The purpose of this study was to find synthetic lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d622bd65b41d9c4313272e0e3a2506d9
https://doi.org/10.1158/2767-9764.c.6597302
https://doi.org/10.1158/2767-9764.c.6597302