Quantitative analysis of hIgG1 in monkey serum by LC–MS/MS using mass spectrometric immunoassay

Autor: Christian Lanshoeft, Olivier Kretz, Olivier Heudi, Andrew Paul Warren, Sarah Cianférani, Franck Picard

Publikováno v: Bioanalysis. 8:1035-1049

Aim: A sensitive generic LC–MS/MS method for hIgG1 quantification in cynomolgus monkey serum using mass spectrometric immunoassay disposable automation research tips (MSIA-D.A.R.T.'S™) is reported. Results: The hIgG1 was captured with a biotinyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477accd2c9daad97b7b858d8bcc6aec0
https://doi.org/10.4155/bio.16.32

Ultrafast quantitative MS-based method for ceritinib analysis in human plasma samples from clinical trial

Autor: Luc Alexis Leuthold, Marc Raccuglia, Olivier Kretz, Christian Lanshoeft, Olivier Heudi, Franck Picard

Publikováno v: Bioanalysis. 7:425-435

Aim: An ultrafast, sensitive, selective and robust LDTD-APCI-MS/MS method was developed for the quantification of ceritinib in human plasma. Results: Samples were protein precipitated using acetonitrile containing [13C6]-ceritinib as internal standar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2459faaa8ddbeb68374151e5d0605eb
https://doi.org/10.4155/bio.14.292

Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF1Antagonist

Autor: Bindi Sohal, Gareth Williams, Olivier Kretz, Joel Krauser, Franck Picard, Rowan Stringer, Jeffrey Mckenna

Publikováno v: Drug Metabolism and Disposition. 42:954-962

Deuterium isotope effects were evaluated as a strategy to optimize the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole (NVS-CRF38), a novel corticotropin-releasing factor rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aed86ebcfdb6b0fa93a23a030e5ad3e
https://doi.org/10.1124/dmd.114.057265

The flexibility of a generic LC-MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies

Autor: Olivier Kretz, Thierry Wolf, Christian Lanshoeft, Markus Walles, Franck Picard, Olivier Heudi, Samuel Barteau, Sarah Cianférani

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2016, 131, pp.214-222. ⟨10.1016/j.jpba.2016.08.039⟩

International audience; An increasing demand of new analytical methods is associated with the growing number of biotherapeutic programs being prosecuted in the pharmaceutical industry. Whilst immunoassay has been the standard method for decades, a gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d319995649da569339d522fc67142539
https://pubmed.ncbi.nlm.nih.gov/27599352

Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism

Autor: Anne Gardin, Bruno Galli, Natalie L. Trevaskis, William N. Charman, Glenn A. Edwards, Olivier Kretz, Christopher J.H. Porter, Silke Appel-Dingemanse, David M. Shackleford

Publikováno v: Pharmaceutical Research. 26:1486-1495

To examine the effect of food on the oral bioavailability of a highly lipophilic, cannabinoid receptor agonist (CRA13) and to explore the basis for the food effect in lymph-cannulated and non-cannulated dogs.Oral bioavailability was assessed in faste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745f0e633c5c4b5343b4af02e35b68f3
https://doi.org/10.1007/s11095-009-9860-z