Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectory

Autor: Benjamin Villalard, Arjan Boltjes, Florie Reynaud, Olivier Imbaud, Karine Thoinet, Ilse Timmerman, Séverine Croze, Emy Theoulle, Gianluigi Atzeni, Joël Lachuer, Jan J. Molenaar, Godelieve A. M. Tytgat, Céline Delloye-Bourgeois, Valérie Castellani

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Despite their indisputable importance in neuroblastoma (NB) pathology, knowledge of the bases of NB plasticity and heterogeneity remains incomplete. They may be rooted in developmental trajectories of their lineage of origin, the sympatho-ad

Externí odkaz: https://doaj.org/article/8eeee38574194e8a84bc12301a8a48bf

An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers

Autor: Loraine Jarrosson, Clélia Costechareyre, Fanny Gallix, Séverine Ciré, Fabien Gay, Olivier Imbaud, Romain Teinturier, Elisabetta Marangoni, Karine Aguéra, Céline Delloye-Bourgeois, Valérie Castellani

Publikováno v: iScience, Vol 24, Iss 12, Pp 103423- (2021)

Summary: Lack of preclinical patient-derived xenograft cancer models in which to conduct large-scale molecular studies seriously impairs the development of effective personalized therapies. We report here an in vivo concept consisting of implanting h

Externí odkaz: https://doaj.org/article/e65639efd1b04677a4ab64cc3627fbe5

Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model

Autor: Dounia Ben Amar, Karine Thoinet, Benjamin Villalard, Olivier Imbaud, Clélia Costechareyre, Loraine Jarrosson, Florie Reynaud, Julia Novion Ducassou, Yohann Couté, Jean-François Brunet, Valérie Combaret, Nadège Corradini, Céline Delloye-Bourgeois, Valérie Castellani

Publikováno v: Nature Communications
Nature Communications, 2022, 13 (1), pp.2549. ⟨10.1038/s41467-022-30237-3⟩

Embryonic malignant transformation is concomitant to organogenesis, often affecting multipotent and migratory progenitors. While lineage relationships between malignant cells and their physiological counterparts are extensively investigated, the cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c6052c87e7efe8470c556a8a02bfdc
https://pubmed.ncbi.nlm.nih.gov/35538114

Draft genome sequences for three unisolated Alnus -infective Frankia Sp+ strains, AgTrS, AiOr and AvVan, the first sequenced Frankia strains able to sporulate in-planta

Autor: Jérôme Briolay, Maria P. Fernandez, Aude Herrera-Belaroussi, Céline Brochier-Armanet, Najwa Taib, Audrey Dubost, Olivier Imbaud, Lucia Castro-Garcia, Pascale Fournier, Danis Abrouk, Florian Vautrin, Philippe Normand, Agnès Nguyen, Lorine Bethencourt

Publikováno v: Journal of Genomics
Journal of Genomics, Ivyspring International Publisher., 2019, 7, pp.50-55. ⟨10.7150/jgen.35875⟩
Journal of Genomics, 2019, 7, pp.50-55. ⟨10.7150/jgen.35875⟩

International audience; Actinobacteria from genus Frankia are able to form symbiotic associations with actinorhizal plants including alders. Among them, Sp+ strains are characterized by their ability to differentiate numerous sporangia inside host pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a9245fd3a7b7a272101ea9e8ce8908
https://hal.archives-ouvertes.fr/hal-03378243