The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels.

Autor: Erik Axelsson, Ingrid Ljungvall, Priyasma Bhoumik, Laura Bas Conn, Eva Muren, Åsa Ohlsson, Lisbeth Høier Olsen, Karolina Engdahl, Ragnvi Hagman, Jeanette Hanson, Dmytro Kryvokhyzha, Mats Pettersson, Olivier Grenet, Jonathan Moggs, Alberto Del Rio-Espinola, Christian Epe, Bruce Taillon, Nilesh Tawari, Shrinivas Mane, Troy Hawkins, Åke Hedhammar, Philippe Gruet, Jens Häggström, Kerstin Lindblad-Toh

Publikováno v: PLoS Genetics, Vol 17, Iss 9, p e1009726 (2021)

Selective breeding for desirable traits in strictly controlled populations has generated an extraordinary diversity in canine morphology and behaviour, but has also led to loss of genetic variation and random entrapment of disease alleles. As a conse

Externí odkaz: https://doaj.org/article/bc00abd03f7a4a5eb45034df9811c21d

Perturbation of microRNAs in rat heart during chronic doxorubicin treatment.

Autor: Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S Paules, François Pognan, Frank Staedtler, Martin P Vidgeon-Hart, Olivier Grenet, Philippe Couttet

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40395 (2012)

Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the cardiovascular system, ultimately causing heart failure. Despite extensive investigations into the eff

Externí odkaz: https://doaj.org/article/1bf1e6df5257478dabeac3b061a4a4f0

The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels

Autor: Shrinivas Mane, Alberto Del Rio-Espinola, Åsa Ohlsson, Åke Hedhammar, Philippe Gruet, Jens Häggström, Mats E. Pettersson, Nilesh R. Tawari, Erik Axelsson, Troy Hawkins, Karolina Engdahl, Lisbeth H. Olsen, Ingrid Ljungvall, Ragnvi Hagman, Dmytro Kryvokhyzha, Olivier Grenet, Jeanette Hanson, Eva Murén, Jonathan G. Moggs, Kerstin Lindblad-Toh, Priyasma Bhoumik, Laura Bas Conn, Christian Epe, Bruce Taillon

Publikováno v: Axelsson, E, Ljungvall, I, Bhoumik, P, Conn, L B, Muren, E, Ohlsson, Å, Olsen, L H, Engdahl, K, Hagman, R, Hanson, J, Kryvokhyzha, D, Pettersson, M, Grenet, O, Moggs, J, Del Rio-Espinola, A, Epe, C, Taillon, B, Tawari, N, Mane, S, Hawkins, T, Hedhammar, Å, Gruet, P, Häggström, J & Lindblad-Toh, K 2021, ' The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels : [+ correction] ', PLOS Genetics, vol. 17, no. 9, e1009726 . https://doi.org/10.1371/journal.pgen.1009726
PLoS Genetics, 17 (9)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009726 (2021)

Selective breeding for desirable traits in strictly controlled populations has generated an extraordinary diversity in canine morphology and behaviour, but has also led to loss of genetic variation and random entrapment of disease alleles. As a conse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da38d6d836f08dd0ce14e097ac93696

Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors

Autor: Philippe Couttet, Jonathan G. Moggs, Valerie Dubost, Antonio Vitobello, Diethilde Theil, Bettina Grasl-Kraupp, Salah-Dine Chibout, Heidrun Ellinger-Ziegelbauer, Hisanori Hara, Colin J. Henderson, Nico Scheer, Rémi Terranova, Harri Lempiäinen, Frank Picard, Michael Schwarz, Clifford R. Elcombe, Pierre Moulin, John P. Thomson, Arne Müller, Olivier Grenet, C. Roland Wolf, Richard R. Meehan, Raphaëlle Luisier, Miriam Geissler, Nina Scherbichler, Albert Braeuning

Publikováno v: Toxicological Sciences. 139:501-511

The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0989ade39f36bbc0e35a0230e8c8d048
https://doi.org/10.1093/toxsci/kfu038

Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome

Autor: Rémi Terranova, Christine McCormack, Fabrizio Gasparini, Olivier Grenet, Thomas Peters, Baltazar Gomez-Mancilla, Izabela Rozenberg, Sébastien Jacquemont, Arne Mueller, Yunsheng He, Sarah Brasa, Salah-Dine Chibout, Jonathan G. Moggs, Florian Hahne

Publikováno v: Clinical Epigenetics, vol. 8, pp. 15
Clinical Epigenetics

Background Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation 1 (FMR1) gene. The molecular pathways associated with FMR1 epigenetic silencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6534b799a3aeda084afa175ad635d097
https://serval.unil.ch/notice/serval:BIB_E81B3663906F