Investigation of the invasion mechanism mediated by the outer membrane protein PagN of Salmonella Typhimurium

Autor: Emilie Barilleau, Mégane Védrine, Michael Koczerka, Julien Burlaud-Gaillard, Florent Kempf, Olivier Grépinet, Isabelle Virlogeux-Payant, Philippe Velge, Agnès Wiedemann

Publikováno v: BMC Microbiology, Vol 21, Iss 1, Pp 1-18 (2021)

Abstract Background Salmonella can invade host cells via a type three secretion system called T3SS-1 and its outer membrane proteins, PagN and Rck. However, the mechanism of PagN-dependent invasion pathway used by Salmonella enterica, subspecies ente

Externí odkaz: https://doaj.org/article/456c8ee3e31145698d9ffc059ef3bd20

H-NS is the major repressor of Salmonella Typhimurium Pef fimbriae expression

Autor: Genaro Alejandro Hurtado-Escobar, Olivier Grépinet, Pierre Raymond, Nadia Abed, Philippe Velge, Isabelle Virlogeux-Payant

Publikováno v: Virulence, Vol 10, Iss 1, Pp 849-867 (2019)

Fimbriae play an important role in adhesion and are therefore essential for the interaction of bacteria with the environments they encounter. Most of them are expressed in vivo but not in vitro, thus making difficult the full characterization of thes

Externí odkaz: https://doaj.org/article/943d7d2e8a7a40018d4e6d6c245b11f5

An Updated View on the Rck Invasin of Salmonella: Still Much to Discover

Autor: Julien Mambu, Isabelle Virlogeux-Payant, Sébastien Holbert, Olivier Grépinet, Philippe Velge, Agnès Wiedemann

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

Salmonella is a facultative intracellular Gram-negative bacterium, responsible for a wide range of food- and water-borne diseases ranging from gastroenteritis to typhoid fever depending on hosts and serotypes. Salmonella thus represents a major threa

Externí odkaz: https://doaj.org/article/d0775726cecf4198936be016933317b3

Rck of Salmonella Typhimurium Delays the Host Cell Cycle to Facilitate Bacterial Invasion

Autor: Yves Le Vern, Agnès Wiedemann, Philippe Velge, Guillaume Sadrin, Frédéric Taieb, Olivier Grépinet, Michel Olivier, Laetitia Fragnet-Trapp, Julien Mambu, Emilie Barilleau

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Frontiers, 2020, 10, ⟨10.3389/fcimb.2020.586934⟩
Frontiers in Cellular and Infection Microbiology, Frontiers, In press, ⟨10.3389/fcimb.2020.586934⟩
Frontiers in Cellular and Infection Microbiology, Frontiers, 2020, 10, 15 p. ⟨10.3389/fcimb.2020.586934⟩
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

Salmonella Typhimurium expresses on its outer membrane the protein Rck which interacts with the epidermal growth factor receptor (EGFR) of the plasma membrane of the targeted host cells. This interaction activates signaling pathways, leading to the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cee2c0a098e01cb3f080b20f2a01613
https://hal.inrae.fr/hal-03081692

Direct regulation of thepefI-srgCoperon encoding the Rck invasin by the quorum-sensing regulator SdiA inSalmonella Typhimurium

Autor: Nadia Abed, Philippe Velge, Agnès Wiedemann, Nolwenn Guichard, Isabelle Virlogeux-Payant, Olivier Grépinet, Sylvie Canepa, Genaro Alejandro Hurtado-Escobar

Publikováno v: Molecular Microbiology. 94:254-271

One important step for the pathogenesis of Salmonella is its ability to penetrate host cells. Recently, a new entry system involving the outer membrane protein Rck has been characterized. Previous studies have shown that the pefI-srgC locus, which co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b0c6b58b8aa6667bb14f546dea56cec
https://doi.org/10.1111/mmi.12738