Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Olivier D. Christophe"'
Autor:
Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva-Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised and phagocy
Externí odkaz:
https://doaj.org/article/d574524e28824efda336edb4bafa128e
Autor:
Thibaud Sefiane, Hortense Maynadié, Carmen Escurola Ettingshausen, Vincent Muczynski, Xavier Heiligenstein, Julien Dumont, Olivier D. Christophe, Cécile V. Denis, Caterina Casari, Peter J. Lenting
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
Recombinant factor VIII (rFVIII), rFVIIIFc and emicizumab are established treatment options in the management of hemophilia A. Each has its unique mode of action, which can influence thrombin generation kinetics and therefore also the kinetics of thr
Externí odkaz:
https://doaj.org/article/87dfb0cfe60b4523b7deb3413f713473
Autor:
Marie‐Daniéla Dubois, Ivan Peyron, Olivier‐Nicolas Pierre‐Louis, Serge Pierre‐Louis, Johalène Rabout, Pierre Boisseau, Annika deJong, Sophie Susen, Jenny Goudemand, Rémi Neviere, Pascal Fuseau, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis, Caterina Casari
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 4, Pp n/a-n/a (2022)
Abstract Background Von Willebrand disease was diagnosed in two Afro‐Caribbean patients and sequencing of the VWF gene (VWF) revealed the presence of multiple variants located throughout the gene, including variants located in the D4 domain of VWF:
Externí odkaz:
https://doaj.org/article/b5a5473594134f32afc891cac997479f
Autor:
Ivan Peyron, Claire Kizlik‐Masson, Marie‐Daniéla Dubois, Sénadé Atsou, Stephen Ferrière, Cécile V. Denis, Peter J. Lenting, Caterina Casari, Olivier D. Christophe
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 7, Pp 1087-1110 (2020)
Abstract Hemostasis is a complex process involving the concerted action of molecular and vascular components. Its basic understanding as well as diagnostic and therapeutic aspects have greatly benefited from the use of monoclonal antibodies. Interest
Externí odkaz:
https://doaj.org/article/28833a87b34b49a9b8815afa9a9a3cb5
Autor:
Sandrine Delignat, Julie Rayes, Suryasarathi Dasgupta, Bagirath Gangadharan, Cécile V. Denis, Olivier D. Christophe, Jagadeesh Bayry, Srinivas V. Kaveri, Sébastien Lacroix-Desmazes
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The development of an immune response against therapeutic factor VIII is the major complication in hemophilia A patients. Oligomannose carbohydrates at N239 and/or N2118 on factor VIII allow its binding to the macrophage mannose receptor expressed on
Externí odkaz:
https://doaj.org/article/56cbe631476a4dda8386f9a407c8d613
Autor:
Caterina Casari, David S. Paul, Sophie Susen, Cécile Lavenu-Bombled, Annie Harroche, Raymond Piatt, Kathryn O. Poe, Robert H. Lee, Marijke Bryckaert, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis, Wolfgang Bergmeier
Publikováno v:
Blood Advances, Vol 2, Iss 12, Pp 1417-1428 (2018)
Abstract: von Willebrand disease (VWD) type 2B is characterized by gain-of-function mutations in von Willebrand factor (VWF), enhancing its binding affinity for the platelet receptor glycoprotein (GP)Ibα. VWD type 2B patients display a bleeding tend
Externí odkaz:
https://doaj.org/article/1507902593a948d4b4b113e3cb58c34b
Autor:
Nikolett Wohner, Vincent Muczynski, Amel Mohamadi, Paulette Legendre, Valérie Proulle, Gabriel Aymé, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis, Caterina Casari
Publikováno v:
Haematologica, Vol 103, Iss 4 (2018)
Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control experiments, however, we observed that von Willebrand factor also binds to macrophages independentl
Externí odkaz:
https://doaj.org/article/262372d980554845a2e76f26c83ee609
Autor:
Julie N. Pegon, Mohamad Kurdi, Caterina Casari, Soline Odouard, Cécile V. Denis, Olivier D. Christophe, Peter J. Lenting
Publikováno v:
Haematologica, Vol 97, Iss 12 (2012)
Background Factor VIII (FVIII) and von Willebrand factor (VWF) circulate in plasma in a tight non-covalent complex, being critical to hemostasis. Although structurally unrelated, both share the presence of sialylated glycan-structures, making them po
Externí odkaz:
https://doaj.org/article/6019b8ab247b447999004a5875f6db07
Autor:
Claire Kizlik-Masson, Ivan Peyron, Stéphane Gangnard, Gaelle Le Goff, Solen M Lenoir, Sandra Damodaran, Marie Clavel, Stéphanie Roullet, Véronique Regnault, Antoine Rauch, Flavien Vincent, Emmanuelle Jeanpierre, Annabelle Dupont, Catherine Ternisien, Thibault Donnet, Olivier D. Christophe, Eric van Belle, Cécile V. Denis, Caterina Casari, Sophie Susen, Peter J. Lenting
Publikováno v:
Blood. 141:1457-1468
von Willebrand factor (VWF) is a multimeric protein, the size of which is regulated via ADAMTS13-mediated proteolysis within the A2 domain. We aimed to isolate nanobodies distinguishing between proteolyzed and non-proteolyzed VWF, leading to the iden
Autor:
Josepha C. Sedzro, Frédéric Adam, Claire Auditeau, Elsa Bianchini, Allan De Carvalho, Ivan Peyron, Sadyo Daramé, Sophie Gandrille, Stella Thomassen, Tilman M. Hackeng, Olivier D. Christophe, Peter J. Lenting, Cécile V. Denis, Delphine Borgel, François Saller
Publikováno v:
Journal of Thrombosis and Haemostasis, 20(7), 1653-1664. Wiley
BACKGROUND: Protein S (PS) is a natural anticoagulant acting as a cofactor for activated protein C (APC) in the proteolytic inactivation of activated factor V (FVa) and VIII (FVIIIa), but also for tissue factor pathway inhibitor α (TFPIα) in the in