Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Olivier Bluteau"'
Autor:
Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Olivier Bluteau, Sylvie Souquère, Delphine Muller, Khadija M. Diop, Philippe Rameau, Valérie Lapierre, Jean-Pierre Marolleau, Patrick Matthias, Isabelle Godin, Gérard Pierron, Steven G. Thomas, Stephen P. Watson, Nathalie Droin, William Vainchenker, Isabelle Plo, Hana Raslova, Najet Debili
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Histone deacetylase (HDAC) inhibitors, a class of cancer therapeutics, cause thrombocytopenia via an unknown mechanism. Here, the authors show that HDAC6 inhibition impairs proplatelet formation in human megakaryocytes, and show that this is linked t
Externí odkaz:
https://doaj.org/article/e6244d22664d4e168a0d548e8a713d18
Autor:
Morgane Hilpert, Céline Legrand, Dominique Bluteau, Natalie Balayn, Aline Betems, Olivier Bluteau, Jean-Luc Villeval, Fawzia Louache, Patrick Gonin, Najet Debili, Isabelle Plo, William Vainchenker, Laure Gilles, Hana Raslova
Publikováno v:
Stem Cell Reports, Vol 3, Iss 6, Pp 1085-1102 (2014)
Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal and the ability to reconstitute the entire hematopoietic compartment. Thrombopoietin maintains adult HSCs in a quiescent state through the induction of cell cycle inhi
Externí odkaz:
https://doaj.org/article/8d362dff690f402983d266a8c9926945
Publikováno v:
BioTechniques, Vol 27, Iss 6, Pp 1100-1102 (1999)
Externí odkaz:
https://doaj.org/article/c373536268ff460eac0495de59938f6a
Autor:
Oriane Marmontel, Yara Abou-Khalil, Olivier Bluteau, Bertrand Cariou, Valérie Carreau, Sybil Charrière, Eleonore Divry, Antonio Gallo, Philippe Moulin, François Paillard, Noel Peretti, Jean-Pierre Rabès, Mathilde Varret, Alain Carrié, Mathilde Di Filippo
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology.
Background: Autosomal dominant hypercholesterolemia (ADH) is due to deleterious variants in LDLR , APOB , or PCSK9 genes. Double heterozygote for these genes induces a more severe phenotype. More recently, a new causative variant of heterozygous ADH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4459236d63a6a40f83db9cce25e10f59
https://doi.org/10.1161/atvbaha.123.319146
https://doi.org/10.1161/atvbaha.123.319146
Autor:
Marie Sebert, Stéphanie Gachet, Thierry Leblanc, Alix Rousseau, Olivier Bluteau, Rathana Kim, Raouf Ben Abdelali, Flore Sicre de Fontbrune, Loïc Maillard, Carèle Fedronie, Valentine Murigneux, Léa Bellenger, Naira Naouar, Samuel Quentin, Lucie Hernandez, Nadia Vasquez, Mélanie Da Costa, Pedro H. Prata, Lise Larcher, Marie de Tersant, Matthieu Duchmann, Anna Raimbault, Franck Trimoreau, Odile Fenneteau, Wendy Cuccuini, Nathalie Gachard, Nathalie Auger, Giulia Tueur, Maud Blanluet, Claude Gazin, Michèle Souyri, Francina Langa Vives, Aaron Mendez-Bermudez, Hélène Lapillonne, Etienne Lengline, Emmanuel Raffoux, Pierre Fenaux, Lionel Adès, Edouard Forcade, Charlotte Jubert, Carine Domenech, Marion Strullu, Bénédicte Bruno, Nimrod Buchbinder, Caroline Thomas, Arnaud Petit, Guy Leverger, Gérard Michel, Marina Cavazzana, Eliane Gluckman, Yves Bertrand, Nicolas Boissel, André Baruchel, Jean-Hugues Dalle, Emmanuelle Clappier, Eric Gilson, Ludovic Deriano, Sylvie Chevret, François Sigaux, Gérard Socié, Dominique Stoppa-Lyonnet, Hugues de Thé, Christophe Antoniewski, Dominique Bluteau, Régis Peffault de Latour, Jean Soulier
Publikováno v:
Cell Stem Cell
Cell Stem Cell, 2023, 30 (2), pp.153-170.e9. ⟨10.1016/j.stem.2023.01.006⟩
Cell Stem Cell, 2023, 30 (2), pp.153-170.e9. ⟨10.1016/j.stem.2023.01.006⟩
International audience; Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid leukemia. Based on a longitudinal cohort of 335 patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04c73d99e0cccd9d3216befe9e7cea
https://hal.science/hal-04157812
https://hal.science/hal-04157812
Autor:
Yara Abou Khalil, Oriane Marmontel, Jean Ferrières, François Paillard, Cécile Yelnik, Valérie Carreau, Sybil Charrière, Eric Bruckert, Antonio Gallo, Philippe Giral, Anne Philippi, Olivier Bluteau, Catherine Boileau, Marianne Abifadel, Mathilde Di-Filippo, Alain Carrié, Jean-Pierre Rabès, Mathilde Varret
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (10), ⟨10.3390/ijms23105792⟩
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5792
International Journal of Molecular Sciences, 2022, 23 (10), ⟨10.3390/ijms23105792⟩
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5792
International audience; Primary hypercholesterolemia is characterized by elevated LDL-cholesterol (LDL-C) levels isolated in autosomal dominant hypercholesterolemia (ADH) or associated with elevated triglyceride levels in familial combined hyperlipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45c9f8851469af1a5395647f1aeef2f
https://hal.science/hal-03772585/file/ijms-23-05792-v3.pdf
https://hal.science/hal-03772585/file/ijms-23-05792-v3.pdf
Autor:
Stefan N. Constantinescu, Xénia Cabagnols, Florence Lorre, Philippe Rameau, Caroline Marty, Florence Pasquier, Valérie Ugo, Jerome Rey, Matthieu Mosca, Isabelle Plo, Amandine Tisserand, William Vainchenker, Mira El-Khoury, Fabrizia Favale, Lydia Roy, Christophe Marzac, Hana Raslova, Najet Debili, Gaëlle Vertenoeil, Olivier Bluteau, Eric Solary, Nicole Casadevall, Graciela Rabadan Moraes, Jean-Christophe Ianotto
Publikováno v:
Oncogene, Vol. 39, no. 31, p. 5323-5337 (2020)
Mutations of calreticulin (CALRm) define a subtype of myeloproliferative neoplasms (MPN). We studied the biological and genetic features of CALR-mutated essential thrombocythemia and myelofibrosis patients. In most cases, CALRm were found in granuloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4394944f20d141ad49d0605ecabce302
https://hdl.handle.net/2078.1/235176
https://hdl.handle.net/2078.1/235176
Autor:
Marie Sebert, Stéphanie Gachet, Thierry Leblanc, Alix Rousseau, Olivier Bluteau, Rathana KIM, Raouf Benabelali, Flore Sicre de Fontbrune, Loïc Maillard, Carèle Fedronie, Nadia Vasquez, Yves Bertrand, Jean-Hugues Dalle, Francois Sigaux, Sylvie Chevret, Gerard Socie, Hugues de Thé, Christophe Antoniewski, Dominique Bluteau, Regis Peffault De Latour, Jean Soulier
Publikováno v:
Blood
Blood, 2021, 138 (Supplement 1), pp.860-860. ⟨10.1182/blood-2021-147811⟩
Blood, 2021, 138 (Supplement 1), pp.860-860. ⟨10.1182/blood-2021-147811⟩
Introduction Fanconi anemia (FA) is the most frequent inherited DNA-repair disease in human, driving hematopoietic stem cell (HSC) failure in children and a major predisposition to poor-prognosis myelodysplastic syndrome (MDS) and acute leukemia (AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3b42f5733964e337e93af142d29eb9
https://doi.org/10.1182/blood-2021-147811
https://doi.org/10.1182/blood-2021-147811
Autor:
Jean-Pierre Marolleau, Delphine Muller, Dominika Sliwa, Khadija M. Diop, Steven G. Thomas, Gérard Pierron, Alberta Palazzo, Patrick Matthias, Nathalie Droin, Isabelle Godin, Isabelle Plo, Philippe Rameau, Hana Raslova, Sylvie Souquere, Stephen P. Watson, Kahia Messaoudi, Najet Debili, William Vainchenker, Olivier Bluteau, Rameez Ishaq, Ashfaq Ali, Valérie Lapierre
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, ⟨10.1038/s41467-017-01690-2⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, ⟨10.1038/s41467-017-01690-2⟩
Thrombocytopenia is a major side effect of a new class of anticancer agents that target histone deacetylase (HDAC). Their mechanism is poorly understood. Here, we show that HDAC6 inhibition and genetic knockdown lead to a strong decrease in human pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0853dae1f6256c46924ede75a1d0b7
http://link.springer.com/article/10.1038/s41467-017-01690-2
http://link.springer.com/article/10.1038/s41467-017-01690-2
Autor:
Maria Paola Martelli, Modi Safra, Aldo Mele, Daphna Nachmani, Olivier Bluteau, Ke Cheng, Tom Vulliamy, Dietmar Bothmer, Silvia Grisendi, Assaf C. Bester, Jonathan D. Lee, John G. Clohessy, Olga Pozdnyakova, Emanuele Monteleone, Inderjeet Dokal, Lucio Luzzatto, Keisuke Ito, Robert B. Darnell, Brunangelo Falini, Schraga Schwartz, Caitlin A. Mitchell, Alison Guzzetti, Lourdes M. Mendez, Jean Soulier, Yang Zhang, Anne Bothmer, Paolo Sportoletti, Pier Paolo Pandolfi
Publikováno v:
Nature Genetics
Nature genetics
Nature genetics
RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2'-O-methylation (2'-O-Me) to the etiology of dyskeratosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bce9af06111dfd64a3ac79aa33964f