Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Olivier Sperandio"'
Autor:
Alexandra Moine-Franel, Fabien Mareuil, Michael Nilges, Constantin Bogdan Ciambur, Olivier Sperandio
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-10 (2024)
Abstract This dataset represents a collection of pocket-centric structural data related to protein-protein interactions (PPIs) and PPI-related ligand binding sites. The dataset includes high-quality structural information on more than 23,000 pockets,
Externí odkaz:
https://doaj.org/article/a14fc158842a4f82ba6fdcdc158ddb10
Autor:
Isabella A. Guedes, André M. S. Barreto, Diogo Marinho, Eduardo Krempser, Mélaine A. Kuenemann, Olivier Sperandio, Laurent E. Dardenne, Maria A. Miteva
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Scoring functions are essential for modern in silico drug discovery. However, the accurate prediction of binding affinity by scoring functions remains a challenging task. The performance of scoring functions is very heterogeneous across diff
Externí odkaz:
https://doaj.org/article/864f5a4a8d6545a5a092b4189c6f4888
Autor:
Jean-François Eléouët, Monika Bajorek, Luis Checa Ruano, Marie Galloux, Jenna Fix, Charles-Adrien Richard, Hortense Decool, Olivier Sperandio, Irina Gutsche, Benjamin Bardiaux
Publikováno v:
J Virol
Journal of Virology
Journal of Virology, 2022, 96 (2), pp.e0090921. ⟨10.1128/JVI.00909-21⟩
Journal of Virology
Journal of Virology, 2022, 96 (2), pp.e0090921. ⟨10.1128/JVI.00909-21⟩
Human metapneumovirus (HMPV) causes severe respiratory diseases in young children. The HMPV RNA genome is encapsidated by the viral nucleoprotein (N), forming an RNA-N complex (N(Nuc)), which serves as the template for genome replication and mRNA tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7efcc80720167008066e4d77c332fd
https://europepmc.org/articles/PMC8791268/
https://europepmc.org/articles/PMC8791268/
Autor:
Luis Checa Ruano, Irina Gutsche, Benjamin Bardiaux, Olivier Sperandio, Jenna Fix, Hortense Decool, Jean-François Eléouët, Monika Bajorek, Marie Galloux, Charles-Adrien Richard
Human metapneumovirus (HMPV) causes severe respiratory diseases in young children. The HMPV RNA genome is encapsidated by the viral nucleoprotein, forming an RNA-N complex (NNuc), which serves as template for genome replication and mRNA transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab996f9a77e07bbbb33efb624bf646c
https://hal-pasteur.archives-ouvertes.fr/pasteur-03380015/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03380015/document
Autor:
Maryse Moya Nilges, A. Moine-Franel, Luis Checa Ruano, Guillaume Bouvier, Vincent Mallet, Karen Druart, Olivier Sperandio
Publikováno v:
Bioinformatics
Bioinformatics, 2021, 38 (5), pp.1261-1268. ⟨10.1093/bioinformatics/btab849⟩
Bioinformatics, 2021, 38 (5), pp.1261-1268. ⟨10.1093/bioinformatics/btab849⟩
MotivationProtein-protein interactions (PPIs) are key elements in numerous biological pathways and the subject of a growing number of drug discovery projects including against infectious diseases. Designing drugs on PPI targets remains a difficult ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625eaed5a5ebfe3409f5b24929121515
https://pubmed.ncbi.nlm.nih.gov/34908131
https://pubmed.ncbi.nlm.nih.gov/34908131
Publikováno v:
Bioautomation, Vol 7, Iss 1, Pp 104-121 (2007)
Recent progress in human genomics and proteomics has significantly increased the number of macromolecular targets potentially involved in drug discovery campaigns. Today technologies like combinatorial chemistry and high-throughput screening (HTS) au
Externí odkaz:
https://doaj.org/article/ff15b8741a9e4e538ca40e68434b1c85
Autor:
Silva Khodjoyan, Deborha Morissette, Fortune Hontonnou, Luis Checa Ruano, Charles-Adrien Richard, Olivier Sperandio, Jean-François Eléouët, Marie Galloux, Philippe Durand, Stéphanie Deville-Foillard, Christina Sizun
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 569
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2023, 24 (1), pp.569. ⟨10.3390/ijms24010569⟩
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2023, 24 (1), pp.569. ⟨10.3390/ijms24010569⟩
International audience; The interaction between Respiratory Syncytial Virus phosphoprotein P and nucleoprotein N is essential for the formation of the holo RSV polymerase that carries out replication. In vitro screening of antivirals targeting the N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe88f8adbe8f1af16ae1a1d74758cba0
https://doi.org/10.3390/ijms24010569
https://doi.org/10.3390/ijms24010569
Autor:
Marie-Edith Gourdel, Christophe Muller, Stéphane Bourg, Philippe Roche, Carine Derviaux, Olivier Sperandio, Bruno O. Villoutreix, David Lagorce, Xavier Morelli, Maria A. Miteva, Jean-Christophe Rain, Laurent Hoffer, Thomas W. Miller, Pascal Bonnet, Nicolas Bosc
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩
ACS Chemical Biology, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩
ACS Chem Biol
ACS Chemical Biology, American Chemical Society, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩
ACS Chemical Biology, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩
ACS Chem Biol
International audience; Protein-protein interactions (PPIs) mediate nearly every cellular process and represent attractive targets for modulating disease states but are challenging to target with small molecules. Despite this, several PPI inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c064c5ef5cfdd9725784bca1ddfacb1
https://hal.archives-ouvertes.fr/hal-02569625/document
https://hal.archives-ouvertes.fr/hal-02569625/document
Autor:
Christelle Reynès, Hélène Host, Anne-Claude Camproux, Guillaume Laconde, Florence Leroux, Anne Mazars, Benoit Deprez, Robin Fahraeus, Bruno O Villoutreix, Olivier Sperandio
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3, p e1000695 (2010)
Protein-protein interactions (PPIs) may represent one of the next major classes of therapeutic targets. So far, only a minute fraction of the estimated 650,000 PPIs that comprise the human interactome are known with a tiny number of complexes being d
Externí odkaz:
https://doaj.org/article/d53d63284ed141c0ba809fd78c0a202c
Autor:
Rachel Torchet, Alexandra Moine-Franel, Hélène Borges, Bryan Brancotte, Olivia Doppelt-Azeroual, Fabien Mareuil, Hervé Ménager, Olivier Sperandio
Publikováno v:
JOBIM (Journées Ouvertes Biologie, Informatique et Mathématiques)
JOBIM (Journées Ouvertes Biologie, Informatique et Mathématiques), Société Française de BioInformatique; GdR Bioinformatique Moléculaire; Institut Francais de Bioinformatique, Jul 2019, Nantes, France
HAL
JOBIM (Journées Ouvertes Biologie, Informatique et Mathématiques), Société Française de BioInformatique; GdR Bioinformatique Moléculaire; Institut Francais de Bioinformatique, Jul 2019, Nantes, France
HAL
International audience; iPPI-DB, for inhibitors of Protein-Protein Interaction DataBase, is a web application first releasedin 2012, which stores physicochemical and pharmacological data about PPI modulators and theirtargets. Users can query the data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b44abe3336adf455214aa3e88d3dd2fe
https://hal-pasteur.archives-ouvertes.fr/pasteur-02867265/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-02867265/document