Výsledky vyhledávání - "Olivier Russo"

Akademický článek

Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

Autor: Emmanuelle Lautié, Olivier Russo, Pierre Ducrot, Jean A. Boutin

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

The screening and testing of extracts against a variety of pharmacological targets in order to benefit from the immense natural chemical diversity is a concern in many laboratories worldwide. And several successes have been recorded in finding new ac

Externí odkaz: https://doaj.org/article/77eed5940f134010b1a53ddd0e4dba64

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Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 1. Manufacture of the Acid Moiety and Development of Some Key Reactions

Autor: Chloé Copin, François Barière, Anthony Craquelin, Solenn Janvier, Sylvain Lemaitre, Sébastien Samson, Sandrine Baillard, Olivier Russo, Christophe Hardouin, Stéphane Le Roux

Publikováno v: Organic Process Research & Development. 24:652-669

Our efforts toward the process development of drug candidate 1 are described in a series of two papers. This manuscript focuses on the synthesis of kilogram quantities of acid precursor 2 to provid...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed4125e9a1becd66e9e190e3d5397143
https://doi.org/10.1021/acs.oprd.9b00364

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Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 2. Manufacture of the 1,3-Diamine Moiety and Improvement of the Final Coupling Reaction

Autor: Stéphane Le Roux, Sandrine Baillard, Olivier Russo, Christophe Hardouin, François Barière, Anthony Craquelin, Mathieu Grandjean, Christine Penloup, Solenn Janvier

Publikováno v: Organic Process Research & Development. 24:670-685

This paper describes the synthesis of kilogram quantities of the sulfonamide moiety 3 involved in a coupling reaction with acid moiety 2 to provide batches of drug candidate 1 for preclinical studi...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dd10adf791c4b850e0120fa8859053e
https://doi.org/10.1021/acs.oprd.9b00367

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Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

Autor: Olivier Russo, Emmanuelle Lautié, Pierre Ducrot, Jean A. Boutin

Publikováno v: Frontiers in Pharmacology
Frontiers in pharmacology, 11:397
Frontiers in Pharmacology, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9706ae0371374a1d444ee25a1773a97
https://pubmed.ncbi.nlm.nih.gov/32317969

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Design, Synthesis, and Biological Evaluation of New 5-HT4 Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease

Autor: Frank Lezoualc'h, Céline Rivière, Jean-Louis Soulier, Jean-Pierre Monti, Olivier Russo, Sames Sicsic, Marthe Cachard-Chastel, Isabelle Berque-Bestel, Tristan Richard, Mireille Giner, Magali Berthouze

Publikováno v: Journal of Medicinal Chemistry. 52:2214-2225

Serotonin 5-HT(4) receptor (5-HT(4)R) agonists are of particular interest for the treatment of Alzheimer's disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (Abeta). However, despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f92df50bc84ffa6d24be4d7e4425ed
https://doi.org/10.1021/jm801327q

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Three-component one-pot process to propargylic amines and related amide and sulfonamide compounds: application to the construction of 2-(aminomethyl)benzofurans and indoles

Autor: Jean-François Peyrat, Sames Sicsic, Nathanael Olivi, Olivier Russo, Isabelle Berque-Bestel, Mouad Alami, Abdallah Hamze, Jean-Daniel Brion, Samir Messaoudi

Publikováno v: Tetrahedron. 63:10671-10683

An efficient palladium–copper-catalyzed three-component assembling of propargyl halides, aryl or heteroaryl halides, and secondary amines is described. A wide variety of tertiary propargylic amines were synthesized in good to excellent yields from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14c97ea2c6ec2ad37adc48d4ec23be78
https://doi.org/10.1016/j.tet.2007.07.096

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A two-step synthesis of aminopropylpiperidines via aminopropargylpyridines, suitable for the synthesis of a new class of 5-HT4 ligands

Autor: Mouad Alami, Olivier Russo, Sames Sicsic, Isabelle Berque-Bestel, Jean-Daniel Brion

Publikováno v: Tetrahedron Letters. 45:7069-7072

A rapid and flexible synthetic approach to {[bis( tert -butoxycarbonyl)amino]propyl}piperidines 5 and related compounds is described. The key step is a three-component coupling process of 2-, 3- or 4-bromopyridine, propargyl bromide and potassium di-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfe07f40d9226ffc981d85c584bbe18
https://doi.org/10.1016/j.tetlet.2004.07.118

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ChemInform Abstract: Three-Component One-Pot Process to Propargylic Amines and Related Amide and Sulfonamide Compounds: Application to the Construction of 2-(Aminomethyl)benzofurans and Indoles

Autor: Jean-François Peyrat, Isabelle Berque-Bestel, Mouad Alami, Olivier Russo, Sames Sicsic, Jean-Daniel Brion, Samir Messaoudi, Abdallah Hamze, Nathanael Olivi

Publikováno v: ChemInform. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adc55c3c8fce042d3351d56656b4b57e
https://doi.org/10.1002/chin.200806047

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Synthesis of specific bivalent probes that functionally interact with 5-HT(4) receptor dimers

Autor: Mireille Giner, Sames Sicsic, Isabelle Berque-Bestel, Olivier Russo, Magali Berthouze, Jean-Louis Soulier, Frank Lezoualc'h, Ralf Jockers, Lucie Rivail

Publikováno v: Journal of medicinal chemistry. 50(18)

G-protein-coupled receptor dimerization directs the design of new drugs that specifically bind to receptor dimers. Here, we generated a targeted series of homobivalent ligands for serotonin 5-HT(4) receptor (5-HT(4)R) dimers composed of two 5-HT(4)R-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7444a10a2871aa88423bf05fc4765ca
https://pubmed.ncbi.nlm.nih.gov/17676726

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Two transmembrane Cys residues are involved in 5-HT4 receptor dimerization

Autor: Frank Lezoualc'h, Lucie Rivail, Sames Sicsic, Olivier Russo, Mohammed Akli Ayoub, Rodolphe Fischmeister, Alexandre Lucas, Isabelle Berque-Bestel, Ralf Jockers, Magali Berthouze

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2007, 356 (3), pp.642-647. ⟨10.1016/j.bbrc.2007.03.030⟩

The 5-HT(4) receptor (5-HT(4)R) belongs to the G-protein-coupled receptor (GPCR) family and is of considerable interest for the development of new drugs to treat gastrointestinal diseases and memory disorders. The 5-HT(4)R exists as a constitutive di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6025b4b84666ac580ac85a3c9552d58
https://pubmed.ncbi.nlm.nih.gov/17379184

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