Výsledky vyhledávání - "Olivier Alibert"

Akademický článek

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

Autor: Elias Bou Samra, Géraldine Buhagiar-Labarchède, Christelle Machon, Jérôme Guitton, Rosine Onclercq-Delic, Michael R. Green, Olivier Alibert, Claude Gazin, Xavier Veaute, Mounira Amor-Guéret

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis, ribonucle

Externí odkaz: https://doaj.org/article/76cbf3a2c1aa4ca09772fdb78864bf44

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BRG1 generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers

Autor: Marina C. Nocente, Anida Mesihovic Karamitsos, Emilie Drouineau, Waad Albawardi, Cécile Dulary, Florence Ribierre, Hélène Picaud, Olivier Alibert, Joël Acker, Jean-Christophe Aude, Nick Gilbert, Françoise Ochsenbein, Sophie Chantalat, Matthieu Gérard

BRG1, the catalytic subunit of the mammalian SWI/SNF complexes, is essential for chromatin opening at enhancers. However, the nature of the open chromatin remains unclear. Here we show that in addition to producing histone-free DNA, BRG1 generates he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5563f1d687d0597593393ff6cecfcc34
https://doi.org/10.1101/2022.09.15.507958

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A New Assay Capturing Chromosome Fusions Shows a Protection Trade-off at Telomeres and NHEJ Vulnerability to Low Density Ionising Radiation

Autor: Stéphane Marcand, Olivier Alibert, Sabrina Pobiega

Publikováno v: Nucleic Acids Research

Chromosome fusions threaten genome integrity and promote cancer by engaging catastrophic mutational processes, namely chromosome breakage-fusion-bridge cycles and chromothripsis. Chromosome fusions are frequent in cells incurring telomere dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfd089ebfa13fce8450bcf9241285f0
https://doi.org/10.1101/2021.05.04.442438

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A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

Autor: Michael R. Green, Rosine Onclercq-Delic, Géraldine Buhagiar-Labarchède, Xavier Veaute, Christelle Machon, Elias Bou Samra, Mounira Amor-Guéret, Claude Gazin, Olivier Alibert, Jérôme Guitton

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-00633-1⟩
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-00633-1⟩
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Cells from Bloom’s syndrome patients display genome instability due to a defective BLM and the downregulation of cytidine deaminase. Here, we use a genome-wide RNAi-synthetic lethal screen and transcriptomic profiling to identify genes enabling BLM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbb1e8153281802632fbddc07686d7f
https://hal.archives-ouvertes.fr/hal-02345938/file/s41467-017-00633-1.pdf

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Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment

Autor: Julie Soutourina, Fanny Eyboulet, Olivier Alibert, Camille Cibot, Thomas Eychenne, Helen Neil, Michel Werner

Publikováno v: Cell Cycle

Mediator is a large multiprotein complex conserved in all eukaryotes. The crucial function of Mediator in transcription is now largely established. However, we found that this complex also plays an important role by connecting transcription with DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5737773c40c3fe4923e987ec2a589b
https://doi.org/10.1101/gad.225813.113

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Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture

Autor: Marie-Bénédicte Barrault, Thomas Eychenne, Elizaveta A. Novikova, Pierre Nicolas, David Cornu, Nuno Peixeiro, Laurent Kuras, Olivier Alibert, Virginie Redeker, Julie Soutourina, Claire Boschiero, Michel Werner

Publikováno v: Genes and Development 18 (30), 2119-2132. (2016)
Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2016, 30 (18), pp.2119-2132. ⟨10.1101/gad.285775.116⟩
Genes and Development, Cold Spring Harbor Laboratory Press, 2016, 30 (18), pp.2119-2132. 〈10.1101/gad.285775.116〉
Genes and Development, 2016, 30 (18), pp.2119-2132. ⟨10.1101/gad.285775.116⟩

Mediator is a large coregulator complex conserved from yeast to humans and involved in many human diseases, including cancers. Together with general transcription factors, it stimulates preinitiation complex (PIC) formation and activates RNA polymera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f845ae2306bfb6bd80b645342585cce
http://prodinra.inra.fr/record/382917

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Genomic binding of Pol III transcription machinery and relationship with TFIIS transcription factor distribution in mouse embryonic stem cells

Autor: Olivier Alibert, Janos Murvai, Lucie Carrière, Ivo G. Gut, Jean-Christophe Aude, Mark Lathrop, Fayçal Boussouar, Mario Foglio, Julie Soutourina, Yad Ghavi-Helm, Céline Keime, Matthieu Gérard, Sylvie Jounier, Marta Gut, Hélène Humbertclaude, Sébastien Graziani, Michel Werner

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2012, 40 (1), pp.270-283. ⟨10.1093/nar/gkr737⟩
Nucleic Acids Research, 2012, 40 (1), pp.270-283. ⟨10.1093/nar/gkr737⟩

RNA polymerase (Pol) III synthesizes the tRNAs, the 5S ribosomal RNA and a small number of untranslated RNAs. In vitro, it also transcribes short interspersed nuclear elements (SINEs). We investigated the distribution of Pol III and its associated tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ed0c9f0a30d9d735c96f981e244d09
https://doi.org/10.1093/nar/gkr737

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Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation

Autor: Paul-Henri Romeo, Olivier Alibert, M A Viganò, David Castel, Ning Wu, Xavier Gidrol, Marie-Anne Debily, Kristiina Iljin, Roberto Mantovani

Publikováno v: Wu, N, Castel, D, Debily, M-A, Vigano, M A, Alibert, O, Mantovani, R, Iljin, K, Romeo, P-H & Gidrol, X 2011, ' Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation ', Journal of Biological Chemistry, vol. 286, no. 23, pp. 20870-20879 . https://doi.org/10.1074/jbc.M110.169433

The inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, ID2, acts as an oncogene and elevated levels of ID2 have been reported in several malignancies. Whereas some inducers of the ID2 gene have been characterized, little is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24eeed85e60cd5f622609aa04d0af748
https://cris.vtt.fi/en/publications/10b7ba91-691a-4a1b-9fbc-b34f4bb5de86

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