Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Olivier, Tenaillon"'
Autor:
Camille d’Humières, Margot Delavy, Laurie Alla, Farid Ichou, Emilie Gauliard, Amine Ghozlane, Florence Levenez, Nathalie Galleron, Benoit Quinquis, Nicolas Pons, Jimmy Mullaert, Antoine Bridier-Nahmias, Bénédicte Condamine, Marie Touchon, Dominique Rainteau, Antonin Lamazière, Philippe Lesnik, Maharajah Ponnaiah, Marie Lhomme, Natacha Sertour, Savannah Devente, Jean-Denis Docquier, Marie-Elisabeth Bougnoux, Olivier Tenaillon, Mélanie Magnan, Etienne Ruppé, Nathalie Grall, Xavier Duval, Dusko Ehrlich, France Mentré, Erick Denamur, Eduardo P. C. Rocha, Emmanuelle Le Chatelier, Charles Burdet, for the PrediRes study group
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract Background Antibiotics notoriously perturb the gut microbiota. We treated healthy volunteers either with cefotaxime or ceftriaxone for 3 days, and collected in each subject 12 faecal samples up to day 90. Using untargeted and targeted phenot
Externí odkaz:
https://doaj.org/article/868dc641a38f41ccb98c0e6e9993a156
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract RNA polymerase (RNAP) is emblematic of complex biological systems that control multiple traits involving trade-offs such as growth versus maintenance. Laboratory evolution has revealed that mutations in RNAP subunits, including RpoB, are fre
Externí odkaz:
https://doaj.org/article/d16934fc926045d6b0a15469f358e7af
Autor:
Meike T. Wortel, Deepa Agashe, Susan F. Bailey, Claudia Bank, Karen Bisschop, Thomas Blankers, Johannes Cairns, Enrico Sandro Colizzi, Davide Cusseddu, Michael M. Desai, Bram vanDijk, Martijn Egas, Jacintha Ellers, Astrid T. Groot, David G. Heckel, Marcelle L. Johnson, Ken Kraaijeveld, Joachim Krug, Liedewij Laan, Michael Lässig, Peter A. Lind, Jeroen Meijer, Luke M. Noble, Samir Okasha, Paul B. Rainey, Daniel E. Rozen, Shraddha Shitut, Sander J. Tans, Olivier Tenaillon, Henrique Teotónio, J. Arjan G. M. deVisser, Marcel E. Visser, Renske M. A. Vroomans, Gijsbert D. A. Werner, Bregje Wertheim, Pleuni S. Pennings
Publikováno v:
Evolutionary Applications, Vol 16, Iss 1, Pp 3-21 (2023)
Abstract Evolution has traditionally been a historical and descriptive science, and predicting future evolutionary processes has long been considered impossible. However, evolutionary predictions are increasingly being developed and used in medicine,
Externí odkaz:
https://doaj.org/article/5d350dba2ce2465ba41df12f9a33a44d
Autor:
Jinju Guk, Antoine Bridier‐Nahmias, Mélanie Magnan, Nathalie Grall, Xavier Duval, Olivier Clermont, Etienne Ruppé, Camille d'Humières, Olivier Tenaillon, Erick Denamur, France Mentré, Jérémie Guedj, Charles Burdet, for the CEREMI study group
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 7, Pp 906-918 (2022)
Abstract Recent studies have highlighted the importance of ecological interactions in dysbiosis of gut microbiota, but few focused on their role in antibiotic‐induced perturbations. We used the data from the CEREMI trial in which 22 healthy volunte
Externí odkaz:
https://doaj.org/article/f98f42159e9d4ed9864a215afe0ec81c
Autor:
Lucile Vigué, Giancarlo Croce, Marie Petitjean, Etienne Ruppé, Olivier Tenaillon, Martin Weigt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Predicting the effects of mutations in a species is a major challenge in genetics. Here, the authors investigate protein sequence landscapes using diverged E. coli sequences, to predict tolerated mutations and capture interactions between mutations.
Externí odkaz:
https://doaj.org/article/96be6879af7f417593b737f8e9c24d48
Autor:
Jessika Consuegra, Joël Gaffé, Richard E. Lenski, Thomas Hindré, Jeffrey E. Barrick, Olivier Tenaillon, Dominique Schneider
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Insertion sequences (IS) are common mobile genetic elements in bacteria, but their effects on bacterial evolution are not well understood. Here, Consuegra and colleagues investigate the dynamics and fitness consequences of IS elements in E. coli over
Externí odkaz:
https://doaj.org/article/e996c6b3661a4328bd3da865b5d3e48a
Autor:
Claire Amaris Hobson, Lucile Vigué, Mélanie Magnan, Benoit Chassaing, Sabrine Naimi, Benoit Gachet, Pauline Claraz, Thomas Storme, Stephane Bonacorsi, Olivier Tenaillon, André Birgy
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundAnticancer drug efficacy is linked to the gut microbiota’s composition, and there is a dire need to better understand these interactions for personalized medicine. In vitro microbiota models are promising tools for studies requiring contr
Externí odkaz:
https://doaj.org/article/79c4f8f0b1ca408a8322cb6234d1cfab
Autor:
Alaksh Choudhury, Jacob A Fenster, Reilly G Fankhauser, Joel L Kaar, Olivier Tenaillon, Ryan T Gill
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 3, Pp 1-22 (2020)
Abstract Deep mutational scanning can provide significant insights into the function of essential genes in bacteria. Here, we developed a high‐throughput method for mutating essential genes of Escherichia coli in their native genetic context. We us
Externí odkaz:
https://doaj.org/article/5f2e06ad113d433aa65e1e649e871ef6
Publikováno v:
Evolutionary Applications, Vol 12, Iss 9, Pp 1721-1742 (2019)
Abstract With the molecular revolution in Biology, a mechanistic understanding of the genotype–phenotype relationship became possible. Recently, advances in DNA synthesis and sequencing have enabled the development of deep mutational scanning assay
Externí odkaz:
https://doaj.org/article/5bb4f6911d0a43829f566e4ba746ae2f
Autor:
Alejandro Couce, Olivier Tenaillon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Mutators are expected to re-evolve low mutation rates to reduce deleterious load, but empirical evidence is mixed. Here, the authors show that load can vary across mutators and genetic backgrounds, which their simulations suggest can substantially al
Externí odkaz:
https://doaj.org/article/67417fa7d81b4f77964910427aefd29a