Electroretinography and contrast sensitivity, complementary translational biomarkers of sensory deficits in the visual system of individuals with fragile X syndrome

Autor: Olivier Perche, Fabien Lesne, Alain Patat, Susanne Raab, Roy Twyman, Robert H. Ring, Sylvain Briault

Publikováno v: Journal of Neurodevelopmental Disorders, Vol 13, Iss 1, Pp 1-19 (2021)

Abstract Background Disturbances in sensory function are an important clinical feature of neurodevelopmental disorders such as fragile X syndrome (FXS). Evidence also directly connects sensory abnormalities with the clinical expression of behavioral

Externí odkaz: https://doaj.org/article/9c4d601052b74f959eff15e4beb639d3

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Autor: Sulayman Benmerzoug, Stéphanie Rose, Badreddine Bounab, David Gosset, Laure Duneau, Pauline Chenuet, Lucile Mollet, Marc Le Bert, Christopher Lambers, Silvana Geleff, Michael Roth, Louis Fauconnier, Delphine Sedda, Clarisse Carvalho, Olivier Perche, David Laurenceau, Bernhard Ryffel, Lionel Apetoh, Ahmet Kiziltunc, Hakan Uslu, Fadime Sultan Albez, Metin Akgun, Dieudonnée Togbe, Valerie F. J. Quesniaux

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)

Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by ST

Externí odkaz: https://doaj.org/article/9888d37e2d5a425d97df7c19aed7823f

Early Retinal Defects in Fmr1−/y Mice: Toward a Critical Role of Visual Dys-Sensitivity in the Fragile X Syndrome Phenotype?

Autor: Olivier Perche, Chloé Felgerolle, Maryvonne Ardourel, Audrey Bazinet, Arnaud Pâris, Rafaëlle Rossignol, Géraldine Meyer-Dilhet, Anne-Laure Mausset-Bonnefont, Betty Hébert, David Laurenceau, Céline Montécot-Dubourg, Arnaud Menuet, Jean-Charles Bizot, Jacques Pichon, Isabelle Ranchon-Cole, Sylvain Briault

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Fragile X Syndrome (FXS) is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuro

Externí odkaz: https://doaj.org/article/111446a59bbf4b50b07bf98d5b7f80f2

Perinatal exposure to glufosinate ammonium herbicide impairs neurogenesis and neuroblast migration through cytoskeleton destabilization

Autor: Ameziane Herzine, Anthony Laugeray, Justyne Feat, Arnaud Menuet, Valérie Quesniaux, Olivier Richard, Jacques Pichon, Céline Montecot-Dubourg, Olivier Perche, Stéphane Mortaud

Publikováno v: Frontiers in Cellular Neuroscience, Vol 10 (2016)

Neurogenesis, a process of generating functional neurons from neural precursors, occurs throughout life in restricted brain regions such as the subventricular zone (SVZ). During this process, newly generated neurons migrate along the rostral migrator

Externí odkaz: https://doaj.org/article/77f1349f6f2940c093c7e4fe4b360e01

Dietary Supplement Enriched in Antioxidants and Omega-3 Promotes Glutamine Synthesis in Müller Cells: A Key Process against Oxidative Stress in Retina

Autor: Khaoula Ramchani Ben Othman, Arnaud Pâris, Rafaëlle Rossignol, Sylvain Briault, Chloé Felgerolle, Maryvonne Ardourel, Olivier Perche, Isabelle Ranchon-Cole, Natsuko Ueda, Niyazi Acar, Betty Hébert, Audrey Bazinet

Publikováno v: Nutrients, Vol 13, Iss 3216, p 3216 (2021)
Nutrients
Nutrients, MDPI, 2021, 13 (9), pp.3216. ⟨10.3390/nu13093216⟩
Nutrients; Volume 13; Issue 9; Pages: 3216

International audience; To prevent ocular pathologies, new generation of dietary supplements have been commercially available. They consist of nutritional supplement mixing components known to provide antioxidative properties, such as unsaturated fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaebc7496fab147594dec2ca2458952e
https://www.mdpi.com/2072-6643/13/9/3216