Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Olivier, Lequin"'
Autor:
Francesca Nuti, Maud Larregola, Agnieszka Staśkiewicz, Bernhard Retzl, Nataša Tomašević, Lorenzo Macchia, Maria E. Street, Michał Jewgiński, Olivier Lequin, Rafal Latajka, Paolo Rovero, Christian W. Gruber, Michael Chorev, Anna Maria Papini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT
Externí odkaz:
https://doaj.org/article/5e89b8ca7f1645cab06fcfd921debf44
Autor:
Sébastien Cardon, Yadira P. Hervis, Gérard Bolbach, Chrystel Lopin-Bon, Jean-Claude Jacquinet, Françoise Illien, Astrid Walrant, Delphine Ravault, Bingwei He, Laura Molina, Fabienne Burlina, Olivier Lequin, Alain Joliot, Ludovic Carlier, Sandrine Sagan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Engrailed2 (En2) is a transcription factor that transfers from cell to cell through unconventional pathways. The poorly understood internalization mechanism of this cationic protein is proposed to require an initial interaction with cell-sur
Externí odkaz:
https://doaj.org/article/c684e2cdb0ba43a69d9c0fdf51449845
Autor:
Philippe Karoyan, Vincent Vieillard, Luis Gómez-Morales, Estelle Odile, Amélie Guihot, Charles-Edouard Luyt, Alexis Denis, Pascal Grondin, Olivier Lequin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Karoyan et al. present a method to inhibit SARS-CoV-2 by means of a peptide-mimic approach. They design a series of peptides mimicking the N-terminal helix of hACE2 protein and their best peptide-mimic blocks SARS-CoV-2 human pulmonary cell infection
Externí odkaz:
https://doaj.org/article/ed692f48c5844ca4b8d6abdcdfbbe19b
Autor:
Fabien Le Chevalier, Isabelle Correia, Lucrèce Matheron, Morgan Babin, Mireille Moutiez, Nicolas Canu, Muriel Gondry, Olivier Lequin, Pascal Belin
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-16 (2020)
Abstract Background Cyclodipeptide oxidases (CDOs) are enzymes involved in the biosynthesis of 2,5-diketopiperazines, a class of naturally occurring compounds with a large range of pharmaceutical activities. CDOs belong to cyclodipeptide synthase (CD
Externí odkaz:
https://doaj.org/article/f25dc7239b8a4460a3d5f4a96e21e08c
Autor:
Pawel Jurkiewicz, Lucile Senicourt, Haitham Ayeb, Olivier Lequin, Jean-Jacques Lacapere, Henri Batoko
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Conserved translocator proteins (TSPOs) mediate cell stress responses possibly in a cell-type-specific manner. This work reports on the molecular function of plant TSPO and their possible evolutionary divergence. Arabidopsis thaliana TSPO (A
Externí odkaz:
https://doaj.org/article/b30ad6c9f7f8472398e599cec3447e41
Autor:
Yaochun Xu, Isabelle Correia, Tap Ha-Duong, Nadjib Kihal, Jean-Louis Soulier, Julia Kaffy, Benoît Crousse, Olivier Lequin, Sandrine Ongeri
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2842-2853 (2017)
Pentapeptides having the sequence R-HN-Ala-Val-X-Val-Leu-OMe, where the central residue X is L-serine, L-threonine, (2S,3R)-L-CF3-threonine and (2S,3S)-L-CF3-threonine were prepared. The capacity of (2S,3S)- and (2S,3R)-CF3-threonine analogues to sta
Externí odkaz:
https://doaj.org/article/53c1aefd96444b4eb73174c4081b5622
Publikováno v:
Journal of the American Chemical Society. 144:14627-14637
Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b90ae1b2d7097f6f6a778cb84667d1
https://doi.org/10.1021/jacs.2c03932
https://doi.org/10.1021/jacs.2c03932
Autor:
Francesca Nuti, Cristina Gellini, Maud Larregola, Lorenzo Squillantini, Riccardo Chelli, Pier Remigio Salvi, Olivier Lequin, Giangaetano Pietraperzia, Anna Maria Papini
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
The insertion of azobenzene moiety in complex molecular protein or peptide systems can lead to molecular switches to be used to determine kinetics of folding/unfolding properties of secondary structures, such as α-helix, β-turn, or β-hairpin. In f
Externí odkaz:
https://doaj.org/article/0334c1bf059047889ec79a8e8a6fb43f
Publikováno v:
Organic & Biomolecular Chemistry. 20:8430-8437
Studies on the synthetic methodologies and the structural propensity of peptides containing consecutive aza-amino acids are still in their infancy. Here, details of the synthesis and conformational analysis of tripeptides containing two consecutive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8c340d63f34cd386c858986e7a81b2
https://doi.org/10.1039/d2ob01225a
https://doi.org/10.1039/d2ob01225a
Autor:
Marion Doladilhe, Vincent Dive, Olivier Lequin, Pierrick Bruyat, Monika Kaminska, Dimitris Georgiadis, Carole Fruchart Gaillard, Mélissa De Souza, Robert Thai, Evelyne Cassar-Lajeunesse, Carole Malgorn, Laurent Devel, Andrzej Galat, Fabrice Beau, Sarah Bregant, Isabelle Correia
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2021, 60 (33), pp.18272-18279. ⟨10.1002/anie.202106117⟩
Angewandte Chemie International Edition, 2021, 60 (33), pp.18272-18279. ⟨10.1002/anie.202106117⟩
International audience; Activity-based probes enable discrimination between the active enzyme and its inactive or inactivated counterparts. Since metalloproteases catalysis is non-covalent, activity-based probes targeting them have been systematicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71534c08742b02912c580f9fcb997039
https://doi.org/10.1002/ange.202106117
https://doi.org/10.1002/ange.202106117