Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Olivier, Giger"'
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Autor:
Alvin Wei Tian Ng, Dylan Peter McClurg, Ben Wesley, Shahriar A. Zamani, Emily Black, Ahmad Miremadi, Olivier Giger, Rogier ten Hoopen, Ginny Devonshire, Aisling M. Redmond, Nicola Grehan, Sriganesh Jammula, Adrienn Blasko, Xiaodun Li, Samuel Aparicio, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Karol Nowicki-Osuch, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly und
Externí odkaz:
https://doaj.org/article/70172e9506b8433ca7874eabf4b5a777
Autor:
Alvin Wei Tian Ng, Dylan Peter McClurg, Ben Wesley, Shahriar A. Zamani, Emily Black, Ahmad Miremadi, Olivier Giger, Rogier ten Hoopen, Ginny Devonshire, Aisling M. Redmond, Nicola Grehan, Sriganesh Jammula, Adrienn Blasko, Xiaodun Li, Samuel Aparicio, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Karol Nowicki-Osuch, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e131446b35e94c42af2e34ae89cd9a66
Autor:
Eleanor Fewings, Serena Khoo Sert Kim, Alexey Larionov, Alison Marker, Olivier Giger, Ashley Shaw, Graeme R Clark, Vasilis Kosmoliaptsis, Benjamin G Challis, Marc Tischkowitz, Ruth T Casey
Publikováno v:
Endocrine Oncology, Vol 1, Iss 1, Pp 33-44 (2023)
Background: Malignant oncocytic adrenocortical neoplasms (OANs) are rare tumours with a distinctive biological behaviour compared to conventional adrenocortical carcinoma (ACC). The current prognostic systems overestimate the malignant potential of t
Externí odkaz:
https://doaj.org/article/207b97908f4244269492d78c015990d7
Autor:
Elizabeth Smyth, Kelly Cozens, Daniel Griffiths, Kathryn L. Clark, Sean Ewings, Russell Petty, Tim Underwood, Rebecca C. Fitzgerald, James Tanner, Olivier Giger, Shubha Anand, Gareth Griffiths
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background For patients with oesophagogastric adenocarcinoma, surgery is the only curative option and despite the use of multimodality therapy, which combines it with chemotherapy and/or radiotherapy, more than 50% of patients will relapse a
Externí odkaz:
https://doaj.org/article/1fbe26fc1abc48ce98b26d076e0a6aee
Autor:
Seong Keat Cheah, Chad Ramese Bisambar, Deborah Pitfield, Olivier Giger, Rogier ten Hoopen, Jose-Ezequiel Martin, Graeme R Clark, Soo-Mi Park, Craig Parkinson, Benjamin G Challis, Ruth T Casey
Publikováno v:
Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-7 (2021)
A 38-year-old female was identified as carrying a heterozygous pathogenic MEN1 variant (c.1304delG) through predictive genetic testing, following a diagnosis of familial hyperparathyroidism. Routine screening for parathyroid and pituitary disease was
Externí odkaz:
https://doaj.org/article/c9f0caffde984c3cbe47f04d220f4b90
Autor:
Luigi Aloj, Olivier Giger, Iosif A. Mendichovszky, Ben G. Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A. Gallagher, Bala Attili, Mary McLean, Robin L. Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R. Maher, Ruth T. Casey
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Background [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor radionuclide therap
Externí odkaz:
https://doaj.org/article/3128c75f9b434cb5bedd12ba6834b549
Autor:
Vasilis Kosmoliaptsis, Ashley Shaw, Benjamin G. Challis, Eleanor Fewings, Marc Tischkowitz, Serena Khoo Sert Kim, Alexey Larionov, Ruth T Casey, Olivier Giger, Alison Marker, Graeme R Clark
Publikováno v:
Endocrine Oncology. 1:33-44
Background Malignant oncocytic adrenocortical neoplasms (OANs) are rare tumours with a distinctive biological behaviour compared to conventional adrenocortical carcinoma (ACC). The current prognostic systems overestimate the malignant potential of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a538d5cf7c92489b70c388cc754a8119
https://doi.org/10.1530/eo-21-0011
https://doi.org/10.1530/eo-21-0011
Autor:
Anton Enright, Faye Rodgers, Alexandra Karcanias, Olivier Giger, Hoopen Rogier ten, Ben Challis, Venkata Bulusu, Eamonn Maher, Ruth Casey
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6bec8254cfc9d64f538a6f5a1b754a
https://doi.org/10.1530/endoabs.86.op6.2
https://doi.org/10.1530/endoabs.86.op6.2
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Eilidh Rivers, Chrysa Kapeni, Carolin M Sauer, Flavio Beke, Stephen Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Godsinia, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J. Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E. Richardson, Brian Huntly, David R. Spring, Mikkel-Ole Skjødt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Leucine-rich repeat-containing G-protein receptor 5 (LGR5) has been characterised as a stem cell and cancer stem cell marker. Previous analyses of LGR5 transcript levels indicate high level expression discriminates malignancies such as colorectal can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b063d90b569482f715ab1d8ee2f0ad58
https://doi.org/10.1101/2022.09.01.506182
https://doi.org/10.1101/2022.09.01.506182
