Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy

Autor: Georges Stepien, Daniel Morvan, Pascal Reynier, Dominique Loiseau, Aicha Demidem, Olivier Douay, Arnaud Chevrollier

Publikováno v: Molecular Carcinogenesis. 48:733-741

Cancer cells mainly rely on glycolysis for energetic needs, and mitochondrial ATP production is almost inactive. However, cancer cells require the integrity of mitochondrial functions for their survival, such as the maintenance of the internal membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22e95b72df6fef09c8f07f428957b8bd
https://doi.org/10.1002/mc.20539

High Birth Weight and Early Postnatal Weight Gain Protect Obese Children and Adolescents From Truncal Adiposity and Insulin Resistance

Autor: Olivier Douay, Régis Coutant, Frédérique Gatelais, Elisabeth Mathieu, Florence Boux de Casson, Stéphanie Rouleau, Natacha Bouhours-Nouet, Sylvie Dufresne

Publikováno v: Diabetes Care. 31:1031-1036

OBJECTIVE—Low birth weight (LBW), no early catch-up weight, and subsequent fat accumulation have been associated with increased risks of insulin resistance from childhood onward and later cardiovascular disease. We sought to clarify the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d83777c3f2c6baf473567a1360ddcbca
https://doi.org/10.2337/dc07-1647

Food restriction affects energy metabolism in rat liver mitochondria

Autor: Jean-François Dumas, Damien Roussel, Patrick Ritz, Françoise Foussard, Olivier Douay, Yves Malthièry, Gilles Simard

Publikováno v: BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2004, 1670, pp.126-131. ⟨10.1016/j.bbagen.2003.11.002⟩
BBA-Biochimica et Biophysica Acta, Elsevier, 2004, 1670 (2), pp.126-31

To examine the effect of 50% food restriction over a period of 3 days on mitochondrial energy metabolism, liver mitochondria were isolated from ad libitum and food-restricted rats. Mitochondrial enzyme activities and oxygen consumption were assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0a9ddfbf7b5f0cdc783e283c99e048
https://doi.org/10.1016/j.bbagen.2003.11.002

Oxygen Consumption and Expression of the Adenine Nucleotide Translocator in Cells Lacking Mitochondrial DNA

Autor: Olivier Douay, Fabienne Vavasseur, Georges Stepien, Arnaud Chevrollier, Gilles Renier, Dominique Loiseau, Yves Malthièry, Pascal Reynier

Publikováno v: Experimental Cell Research. 278:12-18

It has been shown previously that human rho degrees cells, deprived of mitochondrial DNA and consequently of functional oxidative phosphorylation, maintain a mitochondrial membrane potential, which is necessary for their growth. The goal of our study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56597c1ea2bc8db5685d22ee393771b4
https://doi.org/10.1006/excr.2002.5553

Relationships between Placental GH Concentration and Maternal Smoking, Newborn Gender, and Maternal Leptin: Possible Implications for Birth Weight

Autor: Philippe Descamps, Régis Coutant, Elisabeth Mathieu, Stéphanie Rouleau, Philippe Gillard, Frédérique Beringue, Olivier Douay, Jean Marie Limal, Florence Boux de Casson

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:4854-4859

The control of fetal growth depends on multiple hormones, including both IGF-I and placental GH (PGH) in the mother, and IGF-I rather than pituitary GH (pitGH) in the fetus. Leptin, which is produced by adipocytes and syncitiotrophoblast cells, has a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58865ada778a4cf15273df16037feb37
https://doi.org/10.1210/jcem.86.10.7971