Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Olivier, Delaneau"'
Autor:
Antonio Garrido Marques, Simone Rubinacci, Anna-Sapfo Malaspinas, Olivier Delaneau, Bárbara Sousa da Mota
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Low-coverage imputation is becoming ever more present in ancient DNA (aDNA) studies. Imputation pipelines commonly used for present-day genomes have been shown to yield accurate results when applied to ancient genomes. However, post-mortem d
Externí odkaz:
https://doaj.org/article/09ef1be7957a40298ef0e78f4d92473a
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011092 (2024)
Haplotype estimation, or phasing, has gained significant traction in large-scale projects due to its valuable contributions to population genetics, variant analysis, and the creation of reference panels for imputation and phasing of new samples. To s
Externí odkaz:
https://doaj.org/article/048bb794ac0f44a79e5458cb4a356983
Autor:
Bárbara Sousa da Mota, Simone Rubinacci, Diana Ivette Cruz Dávalos, Carlos Eduardo G. Amorim, Martin Sikora, Niels N. Johannsen, Marzena H. Szmyt, Piotr Włodarczak, Anita Szczepanek, Marcin M. Przybyła, Hannes Schroeder, Morten E. Allentoft, Eske Willerslev, Anna-Sapfo Malaspinas, Olivier Delaneau
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Due to postmortem DNA degradation and microbial colonization, most ancient genomes have low depth of coverage, hindering genotype calling. Genotype imputation can improve genotyping accuracy for low-coverage genomes. However, it is unknown h
Externí odkaz:
https://doaj.org/article/558971cda6864dd59a519463d4cccb3c
Multimodal single cell analysis infers widespread enhancer co-activity in a lymphoblastoid cell line
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Non-coding regulatory elements such as enhancers are key in controlling the cell-type specificity and spatio-temporal expression of genes. To drive stable and precise gene transcription robust to genetic variation and environmental stress, g
Externí odkaz:
https://doaj.org/article/b7969bb063da486191dd43dfdf31959e
Autor:
Myriam Rahmouni, Lorenzo De Marco, Jean-Louis Spadoni, Maxime Tison, Raissa Medina-Santos, Taoufik Labib, Josselin Noirel, Ryad Tamouza, Sophie Limou, Olivier Delaneau, Jacques Fellay, Armand Bensussan, Sigrid Le Clerc, Paul J. McLaren, Jean-François Zagury
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionWe have reanalyzed the genomic data of the International Collaboration for the Genomics of HIV (ICGH), centering on HIV-1 Elite Controllers.MethodsWe performed a genome-wide Association Study comparing 543 HIV Elite Controllers with 3,272
Externí odkaz:
https://doaj.org/article/bc2815579cb54e6dbcedfc3a6e493fff
Autor:
Diana Avalos, Guillaume Rey, Diogo M. Ribeiro, Anna Ramisch, Emmanouil T. Dermitzakis, Olivier Delaneau
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
An analysis of cis-regulatory domains (CRDs) among monocytes, neutrophils, and T cells derived from ChIP-seq peaks and methylation data suggests cell-type specific regulatory mechanisms of immunity.
Externí odkaz:
https://doaj.org/article/32975dc4f57f4a8c9b7aaf8d5781771f
Autor:
Vivek Appadurai, Jonas Bybjerg-Grauholm, Morten Dybdahl Krebs, Anders Rosengren, Alfonso Buil, Andrés Ingason, Ole Mors, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Preben B. Mortensen, Olivier Delaneau, Thomas Werge, Andrew J. Schork
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
An analysis of phasing and imputation performances using iPSYCH consortium data across multiple methods and data integration protocols provides a useful framework in designing workflows to construct next-generation biobanks or conduct biobank-scale a
Externí odkaz:
https://doaj.org/article/da68746f7ed94072a9a90b5153feccaf
Autor:
Robin J. Hofmeister, Simone Rubinacci, Diogo M. Ribeiro, Alfonso Buil, Zoltán Kutalik, Olivier Delaneau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Studies on parent-of-origin effects have been limited in terms of sample size due to lack of parental genomes or known genealogies. Here, the authors develop a method to infer the parent-of-origin of an individual alleles in biobank-scale datasets, w
Externí odkaz:
https://doaj.org/article/77090dd6063a448986bd889a487ceecd
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Using single-cell data from cell lines, the co-expression of genes and co-activity of regulatory elements is analyzed, providing insight into shared architecture and regulation between genes.
Externí odkaz:
https://doaj.org/article/c84b92fd8c254b43a4273788374f3fc9
Autor:
Victoria N. Parikh, Alexander G. Ioannidis, David Jimenez-Morales, John E. Gorzynski, Hannah N. De Jong, Xiran Liu, Jonasel Roque, Victoria P. Cepeda-Espinoza, Kazutoyo Osoegawa, Chris Hughes, Shirley C. Sutton, Nathan Youlton, Ruchi Joshi, David Amar, Yosuke Tanigawa, Douglas Russo, Justin Wong, Jessie T. Lauzon, Jacob Edelson, Daniel Mas Montserrat, Yongchan Kwon, Simone Rubinacci, Olivier Delaneau, Lorenzo Cappello, Jaehee Kim, Massa J. Shoura, Archana N. Raja, Nathaniel Watson, Nathan Hammond, Elizabeth Spiteri, Kalyan C. Mallempati, Gonzalo Montero-Martín, Jeffrey Christle, Jennifer Kim, Anna Kirillova, Kinya Seo, Yong Huang, Chunli Zhao, Sonia Moreno-Grau, Steven G. Hershman, Karen P. Dalton, Jimmy Zhen, Jack Kamm, Karan D. Bhatt, Alina Isakova, Maurizio Morri, Thanmayi Ranganath, Catherine A. Blish, Angela J. Rogers, Kari Nadeau, Samuel Yang, Andra Blomkalns, Ruth O’Hara, Norma F. Neff, Christopher DeBoever, Sándor Szalma, Matthew T. Wheeler, Christian M. Gates, Kyle Farh, Gary P. Schroth, Phil Febbo, Francis deSouza, Omar E. Cornejo, Marcelo Fernandez-Vina, Amy Kistler, Julia A. Palacios, Benjamin A. Pinsky, Carlos D. Bustamante, Manuel A. Rivas, Euan A. Ashley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
There is a genetic component to the risk of severe COVID-19, but the genetic effects are difficult to separate from social constructs that covary with genetic ancestry. To address this, the authors identify determinants of COVID-19 severity using adm
Externí odkaz:
https://doaj.org/article/10002eca5587461185e42393a7dc16a5