Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Olivia T. Hix"'
Autor:
Keith A. Gagnon, Jessie Huang, Olivia T. Hix, Veronica W. Hui, Anne Hinds, Esther Bullitt, Jeroen Eyckmans, Darrell N. Kotton, Christopher S. Chen
Publikováno v:
APL Bioengineering, Vol 8, Iss 2, Pp 026126-026126-13 (2024)
Previous lung-on-chip devices have facilitated significant advances in our understanding of lung biology and pathology. Here, we describe a novel lung-on-a-chip model in which human induced pluripotent stem cell-derived alveolar epithelial type II ce
Externí odkaz:
https://doaj.org/article/156561785503486e81a4ba15a22d4b49
Autor:
Konstantinos-Dionysios Alysandratos, Carolina Garcia-de-Alba, Changfu Yao, Patrizia Pessina, Jessie Huang, Carlos Villacorta-Martin, Olivia T. Hix, Kasey Minakin, Claire L. Burgess, Pushpinder Bawa, Aditi Murthy, Bindu Konda, Michael F. Beers, Barry R. Stripp, Carla F. Kim, Darrell N. Kotton
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of human in vitro models. However, AEC2-like cells in culture have yet
Externí odkaz:
https://doaj.org/article/f25a0ef19189460ebd6f7a2ad18d270c
Autor:
Kristine M. Abo, Julio Sainz de Aja, Jonathan Lindstrom-Vautrin, Konstantinos-Dionysios Alysandratos, Alexsia Richards, Carolina Garcia-de-Alba, Jessie Huang, Olivia T. Hix, Rhiannon B. Werder, Esther Bullitt, Anne Hinds, Isaac Falconer, Carlos Villacorta-Martin, Rudolf Jaenisch, Carla F. Kim, Darrell N. Kotton, Andrew A. Wilson
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Type 2 alveolar epithelial cells (AT2s), facultative progenitor cells of the lung alveolus, play a vital role in the biology of the distal lung. In vitro model systems that incorporate human cells, recapitulate the biology of primary AT2s, and interf
Externí odkaz:
https://doaj.org/article/42389eda8ce941c3bc455d6c05c41b76
Autor:
Andrew A. Wilson, Darrell N. Kotton, Claire L. Burgess, Andrea B. Alber, Kayleigh Berthiaume, Carly Merritt, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Olivia T. Hix, Kristine M. Abo, Jessie Huang, Rhiannon B. Werder
Publikováno v:
Journal of Visualized Experiments.
In the lung, the alveolar epithelium is a physical barrier from environmental stimuli and plays an essential role in homeostasis and disease. Type 2 alveolar epithelial cells (AT2s) are the facultative progenitors of the distal lung epithelium. Dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5d07c5a840b5ce17867d47725fecaa
https://doi.org/10.3791/63875-v
https://doi.org/10.3791/63875-v
Autor:
Konstantinos-Dionysios Alysandratos, Carolina Garcia de Alba Rivas, Changfu Yao, Patrizia Pessina, Carlos Villacorta-Martin, Jessie Huang, Olivia T. Hix, Kasey Minakin, Bindu Konda, Barry R. Stripp, Carla F. Kim, Darrell N. Kotton
SummaryThe alveolar epithelial type 2 cell (AEC2) is the facultative progenitor of lung alveoli tasked to maintain distal lung homeostasis. AEC2 dysfunction has been implicated in the pathogenesis of a number of pulmonary diseases, including idiopath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7761895e53321db362f95c771f49b43
https://doi.org/10.1101/2022.02.08.479591
https://doi.org/10.1101/2022.02.08.479591
Autor:
Darrell N. Kotton, Olivia T. Hix, Evan P. Taddeo, Andrew Emili, Anton Petcherski, Rebeca Acín-Pérez, Marall Vedaie, Surafel Mulugeta, Michael F. Beers, Aaron Hamvas, Susan H. Guttentag, J. C. Jean, F. Sessions Cole, Luis R. Rodriguez, Carlos Villacorta-Martin, Lisa R. Young, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Andrew Tilston-Lunel, Orian S. Shirihai, Jennifer A. Wambach, Benjamin C. Blum, Marc Liesa, Seunghyi Kook, Scott J. Russo, Ryan M. Hekman, Xaralabos Varelas
Publikováno v:
Cell reports
SUMMARY Alveolar epithelial type 2 cell (AEC2) dysfunction is implicated in the pathogenesis of adult and pediatric interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF); however, identification of disease-initiating mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609c62cc228f8b27acf0585c5ceb9a2b
http://europepmc.org/articles/PMC8432578
http://europepmc.org/articles/PMC8432578