Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Olivia T Ly"'
Autor:
Xinghang Jiang, Olivia T. Ly, Hanna Chen, Ziwei Zhang, Beatriz A. Ibarra, Mahmud A. Pavel, Grace E. Brown, Arvind Sridhar, David Tofovic, Abigail Swick, Richard Marszalek, Carlos G. Vanoye, Fritz Navales, Alfred L. George, Jr., Salman R. Khetani, Jalees Rehman, Yu Gao, Dawood Darbar, Ankur Saxena
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110395- (2024)
Summary: Developmental causes of the most common arrhythmia, atrial fibrillation (AF), are poorly defined, with compensation potentially masking arrhythmic risk. Here, we delete 9 amino acids (Δ9) within a conserved domain of the giant protein titin
Externí odkaz:
https://doaj.org/article/489be31f1fb44db7b69aaaf61e69c5c9
Autor:
Olivia T. Ly, Hanna Chen, Grace E. Brown, Liang Hong, Xinge Wang, Yong Duk Han, Mahmud Arif Pavel, Arvind Sridhar, Mark Maienschein-Cline, Brandon Chalazan, Sang-Ging Ong, Khaled Abdelhady, Malek Massad, Lona Ernst Rizkallah, Jalees Rehman, Salman R. Khetani, Dawood Darbar
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) can model heritable arrhythmias to personalize therapies for individual patients. Although atrial fibrillation (AF) is a leading cause of cardiovascular morbidity and mortality,
Externí odkaz:
https://doaj.org/article/2cbefd4c83254f4fb0d6f8d93e7817d4
Autor:
Arvind Sridhar, Olivia T Ly, Mahmud Arif Pavel, Hanna Chen, Francisco Gonzalez, Srikanth Perike, Liang Hong, Mark McCauley, Jalees Rehman, Dawood Darbar
Publikováno v:
Circulation Research. 131
Background: Increased free fatty acids (FFA) and FA infiltration, both major hallmarks of obesity can individually modulate changes leading to AF. For example, mass spectrometry on obese mouse heart tissues have shown that saturated FAs (SFA), monoun
Autor:
Seock Won Youn, Brandon Chalazan, Liang Hong, Sang-Ging Ong, Hanna Chen, Joseph C. Wu, Mark Maienschein-Cline, Leo Feferman, Olivia T Ly, Jalees Rehman, Meihong Zhang, Dawood Darbar, Erin Lambers, Arvind Sridhar
Publikováno v:
Stem Cell Reports
Summary Mutations in SCN5A, encoding the cardiac sodium channel, are linked with familial atrial fibrillation (AF) but the underlying pathophysiologic mechanisms and implications for therapy remain unclear. To characterize the pathogenesis of AF-link
Autor:
Arvind Sridhar, Olivia T Ly, Mahmud Arif Pavel, Hanna Chen, Francisco Gonzalez, Srikanth Perike, Liang HONG, Mark McCauley, Jalees Rehman, Dawood Darbar
Publikováno v:
Circulation. 144
Background: Obesity-induced atrial fibrillation (AF) is modulated in part by increased serum free fatty acids (FFA) and FA infiltration of the heart. Mass spectrometry data on obese mice have shown increased saturated FAs (SFA), monounsaturated FAs (
Autor:
Mahmud Arif Pavel, Srikanth Perike, Dawood Darbar, Olivia T Ly, Arvind Sridhar, Jalees Rehman, Hanna Chen, Liang Hong, Mark McCauley
Publikováno v:
Circulation Research. 129
Background: Inducible atrial fibrillation (AF) in diet-induced obese (DIO) mice is mediated in part by a combined effect of ion channel remodeling and atrial fibrosis. NADPH oxidase 2 (NOX2), a major source of reactive oxygen species (ROS) production
Autor:
Seock Won Youn, Liang Hong, Joseph C. Wu, Khaled Abdelhady, Malek G. Massad, Brandon Chalazan, Arvind Sridhar, Dawood Darbar, Mark Maienschein-Cline, Mahmud Arif Pavel, Yong Duk Han, Grace E. Brown, Hanna Chen, Xinge Wang, Olivia T Ly, Jalees Rehman, Salman R. Khetani
Publikováno v:
Circulation Research. 129
Introduction: The limited success of pharmacological approaches to atrial fibrillation ( AF ) is due to limitations of in vitro and in vivo models and inaccessibility of human atrial tissue. Patient-specific induced pluripotent stem cell-derived atri
Publikováno v:
Exp Biol Med (Maywood)
Induced pluripotent stem cells (iPSCs) serve as a robust platform to model several human arrhythmia syndromes including atrial fibrillation (AF). However, the structural, molecular, functional, and electrophysiological parameters of patient-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ed7962b6d8714c76d2f1d426f28333
https://europepmc.org/articles/PMC8381703/
https://europepmc.org/articles/PMC8381703/
Autor:
Joseph C. Wu, Seock Won Youn, Arvind Sridhar, Leo Feferman, Sang-Ging Ong, Jalees Rehman, Hanna Chen, Meihong Zhang, Liang Hong, Dawood Darbar, Mark Maienschein-Cline, Erin Lambers, Brandon Chalazan, Olivia T Ly
Publikováno v:
Circulation. 142
Introduction: Gain-of-function mutations in SCN5A, which encodes the cardiac sodium channel, have been linked with familial atrial fibrillation (AF). However, the mechanistic link between the late sodium current (I Na,L ) and triggered arrhythmia rem
Autor:
Khaled Abdelhady, Zain Alzahrani, Yong Duk Han, Seock Won Youn, Salman R. Khetani, Malek G. Massad, Dawood Darbar, Hanna Chen, Arvind Sridhar, Grace E. Brown, Meihong Zhang, Liang Hong, Olivia T Ly
Publikováno v:
Circulation. 142
Introduction: Increasingly, human induced pluripotent stem cells (hiPSC) faithfully recapitulate human models of arrhythmias. However, enhancing hiPSC-derived atrial cardiomyocyte (aCM) maturity is vital as modeling mature CMs will provide insights i