Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Olivia Simma"'
Autor:
Eva Eckelhart, Siegfried Weiss, Dagmar Gotthardt, Nina Neugebauer, Nadine Moritz, Stefan Lienenklaus, Dagmar Stoiber, Olivia Simma, Eva Zebedin-Brandl, Eva Maria Putz, Tatsuaki Mizutani, Veronika Sexl, Ulrich Kalinke, Birgit Strobl, Mathias Müller, Wolfgang Warsch, Hans-Peter Kantner
Publikováno v:
Oncoimmunology
Mice with an impaired Type I interferon (IFN) signaling (IFNAR1- and IFNβ-deficient mice) display an increased susceptibility toward v-ABL-induced B-cell leukemia/lymphoma. The enhanced leukemogenesis in the absence of an intact Type I IFN signaling
Autor:
Edit Porpaczy, Ana-Iris Schmatz, Eva Maria Putz, Nadine Moritz, Berthold Streubel, Angelika Berger, Veronika Sexl, Mathias Müller, Christian Schuster, Olivia Simma, Maria Agnes Hoelzl, Anna Frenzel, Michael Freissmuth, Leonard Müllauer, Ulrich Jäger, Andreas Villunger, Dagmar Stoiber, Boris Kovacic, Andrea Hoelbl
Publikováno v:
Blood. 118:4635-4645
In Eμ-myc transgenic animals lymphoma formation requires additional genetic alterations, which frequently comprise loss of p53 or overexpression of BCL-2. We describe that the nature of the “second hit” affects the ability of the immune system t
Autor:
Karen Lingnau, Veronika Sexl, Ulrich Kalinke, Alexander von Gabain, Wolfgang Kratky, Thomas Rülicke, Thomas Kolbe, Mathias Müller, Andreas Pilz, Dagmar Stoiber, Olivia Simma, Silvia Stockinger, Thomas Decker
Publikováno v:
The Journal of Immunology. 183:2286-2293
Phosphorylation of transcription factor STAT-1 on Y701 regulates subcellular localization whereas phosphorylation of the transactivating domain at S727 enhances transcriptional activity. In this study, we investigate the impact of STAT-1 and the impo
Autor:
Dagmar Stoiber, Sabine Fajmann, Christian Baumgartner, Olivia Simma, Michael Freissmuth, Johannes A. Schmid, Eva Weisz, Eva Maria Putz, Wolfgang Warsch, Winfried F. Pickl, Christian Schuster, Veronika Sexl, Roland P. Piekorz, Peter Valent, Eva Eckelhart, Eva Zebedin
Publikováno v:
Blood. 112:4655-4664
Specific inhibitors of PI3K isoforms are currently evaluated for their therapeutic potential in leukemia. We found that BCR/ABL+ human leukemic cells express PI3Kδ and therefore explored its impact on leukemia development. Using PI3Kδ-deficient mic
Autor:
Hartmut Beug, Boris Kovacic, Lothar Hennighausen, Veronika Sexl, Marc A. Kerenyi, Andrea Hoelbl, Olivia Simma, Wolfgang Warsch, Richard Moriggl, Yongzhi Cui
Publikováno v:
Blood. 107:4898-4906
The Stat5 transcription factors Stat5a and Stat5b have been implicated in lymphoid development and transformation. Most studies have employed Stat5a/b-deficient mice where gene targeting disrupted the first protein-coding exon, resulting in the expre
Autor:
Karoline Kollmann, Christine Schneckenleithner, Gerwin Heller, Veronika Sexl, Eva Eckelhart, Olivia Simma, Eva Zebedin-Brandl, Andrea Hoelbl, Rene G. Ott, Sabine Zöchbauer-Müller, Ruth Scheicher, Marcos Malumbres, Martin Bilban, Wolfgang Warsch
Publikováno v:
Blood. 117(15)
The transcription factor c-JUN and its upstream kinase JNK1 have been implicated in BCR-ABL–induced leukemogenesis. JNK1 has been shown to regulate BCL2 expression, thereby altering leukemogenesis, but the impact of c-JUN remained unclear. In this
Autor:
Thomas Kolbe, Dagmar Stoiber, Wolfgang Warsch, Olivia Simma, Emilio Casanova, Eva Zebedin, Thomas Rülicke, Veronika Sexl, Eva Eckelhart, Mathias Mueller
Publikováno v:
Blood. 117(5)
We generated a transgenic mouse line that expresses the Cre recombinase under the control of the Ncr1 (p46) promoter. Cre-mediated recombination was tightly restricted to natural killer (NK) cells, as revealed by crossing Ncr1-iCreTg mice to the eGFP
Autor:
Thomas Decker, Andreas Pilz, Michaela Prchal, Birgit Strobl, Karen Lingnau, Mathias Müller, Alexander von Gabain, Olivia Simma
Publikováno v:
Vaccine. 27
Originally identified as antiviral substances produced by infected cells, type I interferons (IFN-I) are now known to have a wide range of additional activities within both the innate and adaptive immune response. Here we review properties of IFN-I c
Autor:
Anna Frenzel, Mathias Müller, Andreas Villunger, Andrea Hölbl, Olivia Simma, Dagmar Stoiber, Christian Schuster, Veronika Sexl
Publikováno v:
BMC Pharmacology
The process of cancerogenesis is driven by the hierarchical accumulation of genetic changes. So, beside the deregulated expression of an oncogen, additional genetic defects have to take place in order to transform a normal cell into a tumor cell. In
Autor:
Eva Eckelhart, Christian Schuster, Eva-Maria Zebedin, Eva Weisz, Winfried F. Pickl, Wolgang Warsch, Dagmar Stoiber, Roland P. Piekorz, Olivia Simma, Michael Freissmuth, Veronika Sexl
Publikováno v:
BMC Pharmacology. 7
The PI3Kδ isoform is a candidate drug target in leukemia. Here, we explored its role in Abelson-induced leukemia. Frank leukemia emerges if the tumor cells have managed to outwit the immune system. The absence of PI3Kδ affected both the tumor cells