NSD1 mitigates caspase-1 activation by listeriolysin O in macrophages.

Autor: Olivia S Sakhon, Kaitlin A Victor, Anthony Choy, Tokuji Tsuchiya, Thomas Eulgem, Joao H F Pedra

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75911 (2013)

Mammals and plants share pathogen-sensing systems named nod-like receptors (NLRs). Some NLRs form the inflammasome, a protein scaffold that regulates the secretion of interleukin (IL)-1β and IL-18 by cleaving catalytically inactive substrates into m

Externí odkaz: https://doaj.org/article/5f43a6f3cfc942b5b614809e1261168a

The E3 Ubiquitin Ligase XIAP Restricts Anaplasma phagocytophilum Colonization of Ixodes scapularis Ticks

Autor: Duk-Won D. Chung, Anthony Choy, Karine G. Le Roch, Joao H. F. Pedra, Olivia S. Sakhon, Gregor Blaha, Kimberly D. Stephens, Gang Chen, Maiara S. Severo

Publikováno v: The Journal of Infectious Diseases, vol 208, iss 11

Ubiquitination is a posttranslational modification that regulates protein degradation and signaling in eukaryotes. Although it is acknowledged that pathogens exploit ubiquitination to infect mammalian cells, it remains unknown how microbes interact w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a215a60f8333e8dec515f7132510b7
https://doi.org/10.1093/infdis/jit380

Anaplasma phagocytophilum Dihydrolipoamide Dehydrogenase 1 Affects Host-Derived Immunopathology during Microbial Colonization

Autor: Hilda Wiryawan, Ulrike G. Munderloh, Roderick F. Felsheim, Jennifer L. Johns, Joao H. F. Pedra, Jiayu Liao, Michail Kotsyfakis, Maiara S. Severo, Gang Chen, Fayyaz S. Sutterwala, Anthony Choy, Michael J. Herron, Olivia S. Sakhon

Publikováno v: Infection and immunity, vol 80, iss 9

Anaplasma phagocytophilum is a tick-borne rickettsial pathogen that provokes an acute inflammatory response during mammalian infection. The illness caused by A. phagocytophilum , human granulocytic anaplasmosis, occurs irrespective of pathogen load a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2fe12143069b915795be2ff56de84f
https://doi.org/10.1128/iai.00532-12

A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva

Autor: Olivia S. Sakhon, Maiara S. Severo, Michail Kotsyfakis, Joao H. F. Pedra

Publikováno v: Frontiers in Microbiology, Vol 4 (2013)
Frontiers in Microbiology

Arthropod saliva possesses anti-hemostatic, anesthetic, and anti-inflammatory properties that facilitate feeding and, inadvertently, dissemination of pathogens. Vector-borne diseases caused by these pathogens affect millions of people each year. Many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5087fa5818846b9cf22582e0e5712a
http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00308/full

Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells

Autor: Joao H. F. Pedra, Michail Kotsyfakis, Stephen K. Wikel, Gang Chen, Maiara S. Severo, Mohammad Sohail, Olivia S. Sakhon

Publikováno v: Parasites & Vectors, Vol 5, Iss 1, p 229 (2012)
Chen, Gang; Severo, Maiara S; Sohail, Mohammad; Sakhon, Olivia S; Wikel, Stephen K; Kotsyfakis, Michail; et al.(2012). Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells. Parasites & Vectors, 5(1), 229. doi: http://dx.doi.org/10.1186/1756-3305-5-229. Retrieved from: http://www.escholarship.org/uc/item/4568r0x3
Parasites & Vectors

Background Ixodes scapularis saliva enables the transmission of infectious agents to the mammalian host due to its immunomodulatory, anesthetic and anti-coagulant properties. However, how I. scapularis saliva influences host cytokine secretion in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9a7bd011954b6d41e74dbaa713f9a6
https://doi.org/10.1186/1756-3305-5-229