Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Olivia R. Buonarati"'
Autor:
Jonathan E. Tullis, Olivia R. Buonarati, Steven J. Coultrap, Ashley M. Bourke, Erika L. Tiemeier, Matthew J. Kennedy, Paco S. Herson, K. Ulrich Bayer
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103214- (2021)
Summary: Binding of two different CaM kinases, CaMKII and DAPK1, to the NMDA-type glutamate receptor (NMDAR) subunit GluN2B near S1303 has been implicated in excitotoxic/ischemic neuronal cell death. The GluN2BΔCaMKII mutation (L1298A, R1300Q) is ne
Externí odkaz:
https://doaj.org/article/f415611452a44fc8862991682f4e7cfa
Autor:
Olivia R. Buonarati, Sarah G. Cook, Dayton J. Goodell, Nicholas E. Chalmers, Nicole L. Rumian, Jonathan E. Tullis, Susana Restrepo, Steven J. Coultrap, Nidia Quillinan, Paco S. Herson, K. Ulrich Bayer
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 1-8.e4 (2020)
Summary: DAPK1 binding to GluN2B was prominently reported to mediate ischemic cell death in vivo. DAPK1 and CaMKII bind to the same GluN2B region, and their binding is mutually exclusive. Here, we show that mutating the binding region on GluN2B (L129
Externí odkaz:
https://doaj.org/article/0747266e16f346cea222f1e38a2efe82
Publikováno v:
The Journal of biological chemistry, vol 299, iss 6
Learning, memory, and cognition are thought to require synaptic plasticity, specifically including hippocampal long-term potentiation and depression (LTP and LTD). LTP versus LTD is induced by high-frequency stimulation versus low-frequency, but stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb88ebf6c65cc0e3753e0eb11257cb42
https://escholarship.org/uc/item/5vf626vd
https://escholarship.org/uc/item/5vf626vd
Autor:
Maria Paz Prada, Arsalan U Syed, Olivia R Buonarati, Gopireddy R Reddy, Matthew A Nystoriak, Debapriya Ghosh, Sergi Simó, Daisuke Sato, Kent C Sasse, Sean M Ward, Luis F Santana, Yang K Xiang, Johannes W Hell, Madeline Nieves-Cintrón, Manuel F Navedo
Publikováno v:
eLife, Vol 8 (2019)
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA med
Externí odkaz:
https://doaj.org/article/834ddbe5b2af4b2d9cbfe39b3182cbe7
Publikováno v:
F1000Research, Vol 6 (2018)
Background: The L-type Ca2+ channel Cav1.2 is a prominent regulator of neuronal excitability, synaptic plasticity, and gene expression. The central element of Cav1.2 is the pore-forming α11.2 subunit. It exists in two major size forms, whose molecul
Externí odkaz:
https://doaj.org/article/cf4f740fc3774f34aecc813584a3d9dc
Autor:
Nicole L. Rumian, Carolyn Nicole Brown, Tara B. Hendry-Hofer, Thomas Rossetti, James E. Orfila, Jonathan E. Tullis, Linda P. Dwoskin, Olivia R. Buonarati, John E. Lisman, Nidia Quillinan, Paco S. Herson, Vikhyat S. Bebarta, K. Ulrich Bayer
Publikováno v:
Journal of Biological Chemistry. 299:104693
Publikováno v:
F1000Research, Vol 6 (2017)
Background: The L-type Ca2+ channel Cav1.2 is a prominent regulator of neuronal excitability, synaptic plasticity, and gene expression. The central element of Cav1.2 is the pore-forming α11.2 subunit. It exists in two major size forms, whose molecul
Externí odkaz:
https://doaj.org/article/36b867a70dc34d9eb6b1b380773a6f51
Learning, memory and cognition are thought to require forms of synaptic plasticity such as hippocampal long-term potentiation and depression (LTP and LTD), and such plasticity can be modulated by β-adrenergic stimulation with isoproterenol or norepi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d12c605b5bd5914f51dd8461907f540e
https://doi.org/10.1101/2022.06.23.497296
https://doi.org/10.1101/2022.06.23.497296
Autor:
William E. Louch, Ivar Sjaastad, Geir Christensen, Johannes W. Hell, Jan Magnus Aronsen, Alessandro Cataliotti, David B. Lipsett, Einar Sjaastad Norden, Michael Frisk, Olivia R. Buonarati
Publikováno v:
The Journal of Physiology
The Journal of physiology, vol 597, iss 7
The Journal of physiology, vol 597, iss 7
Key points As reactivation of the fetal gene program has been implicated in pathological remodelling during heart failure (HF), we examined whether cardiomyocyte subcellular structure and function revert to an immature phenotype during this disease.S
Publikováno v:
Science Advances
Molecular signal computation within the CaMKII holoenzyme determines the direction of synaptic plasticity.
Higher brain functions are thought to require synaptic frequency decoding that can lead to long-term potentiation (LTP) or depression (LTD
Higher brain functions are thought to require synaptic frequency decoding that can lead to long-term potentiation (LTP) or depression (LTD