The Mediator kinase module: an interface between cell signaling and transcription

Autor: Olivia Luyties, DYLAN TAATJES

Publikováno v: Trends Biochem Sci

The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the assembly of pol II regulatory factors at transcription start sites, and by mediating interactions between enhancer-bound transcription factors (TFs) and the pol II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416a55614205d46475cd29fa42f6a79e
https://doi.org/10.1016/j.tibs.2022.01.002

TFIID Enables RNA Polymerase II Promoter-Proximal Pausing

Autor: Jonathan D. Rubin, Jenna K. Rimel, Charli B. Fant, Zachary L. Maas, Dylan J. Taatjes, Meagan N. Esbin, Michael T. Marr, John Moir, Cecilia B. Levandowski, Kapil Gupta, Andrew Sawyer, Olivia Luyties, Robin D. Dowell, Imre Berger

Publikováno v: Fant, C B, Levandowski, C B, Gupta, K, Maas, Z L, Moir, J, Rubin, J D, Sawyer, A, Esbin, M N, Rimel, J K, Luyties, O, Marr, M T, Berger, I, Dowell, R D & Taatjes, D J 2020, ' TFIID Enables RNA Polymerase II Promoter-Proximal Pausing ', Molecular Cell, vol. 78, no. 4, pp. 785-793.e8 . https://doi.org/10.1016/j.molcel.2020.03.008
Mol Cell

Summary RNA polymerase II (RNAPII) transcription is governed by the pre-initiation complex (PIC), which contains TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, RNAPII, and Mediator. After initiation, RNAPII enzymes pause after transcribing less than 100 b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f69ca34ab9220900fbd1069a208f44
https://doi.org/10.2139/ssrn.3429345